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2-Chloro-N-(2,6-dimethylphenyl)acetamide

2-Chloro-N-(2,6-dimethylphenyl)acetamide structure

CAS No.: 1131-01-7

Chemical Name:: 2-Chloro-N-(2,6-dimethylphenyl)acetamide

Synonyms: Lidocaine EP Impurity H;NSC 37260;2-Chloro-N-(2;acetoxylidide;AKOS BBS-00000875;LIDOCAINE EP IMP H;TIMTEC-BB SBB003566;IFLAB-BB F0133-0019;Chloroacet-2,6-xylide;CHLORO ACETYL XYLIDIDE

CBNumber:: CB0151081

Molecular Formula:: C10H12ClNO

Molecular Weight:: 197.66

MDL Number:: MFCD00000926

MOL File:: 1131-01-7.mol

MSDS File:: SDS

Last updated:2026-01-13 11:12:47

Product description	Number	Pack Size	Price
N-(2,6-Dimethylphenyl)chloroacetamide Pharmaceutical Secondary Standard; Certified Reference Material	PHR1673	100mg	$801
N-(2,6-Dimethylphenyl)chloroacetamide 99%	194921	10g	$86.9
Lidocaine Related Compound H United States Pharmacopeia (USP) Reference Standard	1366080	50MG	$1570
2-Chloro-2',6'-dimethylacetanilide >98.0%(GC)(N)	C2307	5g	$35
2-Chloro-2',6'-dimethylacetanilide >98.0%(GC)(N)	C2307	25g	$85
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2-Chloro-N-(2,6-dimethylphenyl)acetamide Properties

Melting point	150-151 °C(lit.)
Boiling point	316.8±30.0 °C(Predicted)
Density	1.1363 (rough estimate)
refractive index	1.5330 (estimate)
storage temp.	2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka	12.91±0.70(Predicted)
form	Crystalline Powder or Needles
color	White to brown
Water Solubility	Soluble in Chloroform, Methanol. Insoluble in water.
BRN	781309
Stability	Light Sensitive
InChI	1S/C10H12ClNO/c1-7-4-3-5-8(2)10(7)12-9(13)6-11/h3-5H,6H2,1-2H3,(H,12,13)
InChIKey	FPQQSNUTBWFFLB-UHFFFAOYSA-N
SMILES	Cc1cccc(C)c1NC(=O)CCl
CAS DataBase Reference	1131-01-7(CAS DataBase Reference)
FDA UNII	5D2B69OAPX
NIST Chemistry Reference	2-Chloro-2',6'-acetoxylidide(1131-01-7)
EPA Substance Registry System	Acetamide, 2-chloro-N-(2,6-dimethylphenyl)- (1131-01-7)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-37/39

WGK Germany

TSCA

TSCA listed

HazardClass

IRRITANT

HS Code

29214200

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

2-Chloro-N-(2,6-dimethylphenyl)acetamide price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR1673	N-(2,6-Dimethylphenyl)chloroacetamide Pharmaceutical Secondary Standard; Certified Reference Material	1131-01-7	100mg	$801	2026-04-30	Buy
Sigma-Aldrich	194921	N-(2,6-Dimethylphenyl)chloroacetamide 99%	1131-01-7	10g	$86.9	2026-04-30	Buy
Sigma-Aldrich	1366080	Lidocaine Related Compound H United States Pharmacopeia (USP) Reference Standard	1131-01-7	50MG	$1570	2026-04-30	Buy
TCI Chemical	C2307	2-Chloro-2',6'-dimethylacetanilide >98.0%(GC)(N)	1131-01-7	5g	$35	2026-04-30	Buy
TCI Chemical	C2307	2-Chloro-2',6'-dimethylacetanilide >98.0%(GC)(N)	1131-01-7	25g	$85	2026-04-30	Buy

Product number	Packaging	Price	Buy
PHR1673	100mg	$801	Buy
194921	10g	$86.9	Buy
1366080	50MG	$1570	Buy
C2307	5g	$35	Buy
C2307	25g	$85	Buy

2-Chloro-N-(2,6-dimethylphenyl)acetamide Chemical Properties,Uses,Production

Chemical Properties

beige needles or crystalline powder

Uses

2-Chloro-2',6'-dimethylacetanilide is used in the determination of the enantiomers of tocainide in blood plasma by gas-liquid chromatography with electron-capture detection. It is a nonsteroidal antinflammatory drug.

Uses

Lidocaine intermediate.

General Description

N-(2,6-Dimethylphenyl)chloroacetamide (2-chloro-2′,6′-acetoxylidide) is nonsteroidal antinflammatory drug.

Synthesis

593-71-5

28556-81-2

2-Chloro-N-(2,6-dimethylphenyl)acetamide

1131-01-7

General method: Chloroiodomethane (1.5 eq.) is slowly added to a solution of 2,6-dimethylphenyl isocyanate (1.0 eq.) in anhydrous ether (1 M concentration) at -78 °C. After 2 minutes of reaction, a 1.5 M solution of methyl lithium-lithium bromide (1.25 equiv.) ether was added dropwise over 5 minutes. Maintaining this temperature, the reaction mixture was stirred for the indicated time (see Table 1 and Scheme 2 for specific times). Upon completion of the reaction, aqueous ammonium chloride solution (2 mL/mmol substrate) was added, the cooling bath was removed, and stirring was continued until the mixture was brought to room temperature. Subsequently, the reaction mixture was extracted with ether (2 x 5 mL) and the organic phase was washed sequentially with water (5 mL) and brine (10 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give pure 2,6-dimethylchloroacetanilide.

References

[1] Chemical Communications, 2013, vol. 49, # 75, p. 8383 - 8385
[2] Synthesis (Germany), 2014, vol. 46, # 21, p. 2897 - 2909

2-Chloro-N-(2,6-dimethylphenyl)acetamide synthesis

Synthesis of 2-Chloro-N-(2,6-dimethylphenyl)acetamide from 2,6-Dimethylaniline

2-Chloro-N-(2,6-dimethylphenyl)acetamide Preparation Products And Raw materials

Raw materials

N-Methylaniline Anhydrous benzene Chloroacetyl chloride Chloroiodomethane 2,6-Dimethylaniline

2,6-Dimethyl-1-nitrobenzene 2,6-Dimethylphenyl isocyanate Sodium acetate Sodium bicarbonate Chloroacetic anhydride

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Preparation Products

Pyrazole Nefiracetam Lidocaine Impurity

2-Chloro-N-(2,6-dimethylphenyl)acetamide Suppliers

Global( 400)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+8617392709771	1097@dideu.com	China	3996	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21590	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29819	58
Jinan Shengqi pharmaceutical Co,Ltd	86+18663751872	christine@shengqipharm.com	CHINA	491	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Jinan Shengqi pharmaceutical Co,Ltd	58
Accela ChemBio Inc.	58
Xiamen AmoyChem Co., Ltd	58
Standardpharm Co. Ltd.	58
Alchem Pharmtech,Inc.	58

View Lastest Price from 2-Chloro-N-(2,6-dimethylphenyl)acetamide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-30	2-Chloro-N-(2,6-dimethylphenyl)acetamide 1131-01-7	US $0.00-0.00 / Kg/Drum	1KG	98%min	500kg	WUHAN FORTUNA CHEMICAL CO., LTD
2026-04-17	2-Chloro-N-(2,6-dimethylphenyl)acetamide 1131-01-7	US $1.00 / kg	1kg	98	1000	S&Y Biochem Co.,Ltd
2026-03-12	Lidocaine EP Impurity H 1131-01-7	US $0.00-0.00 / mg	10mg	0.98	10g	ShenZhen H&D Pharmaceutical Technology Co., LTD

2-Chloro-N-(2,6-dimethylphenyl)acetamide
1131-01-7
US $0.00-0.00 / Kg/Drum
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

2-Chloro-N-(2,6-dimethylphenyl)acetamide
1131-01-7
US $1.00 / kg
98
S&Y Biochem Co.,Ltd

Lidocaine EP Impurity H
1131-01-7
US $0.00-0.00 / mg
0.98
ShenZhen H&D Pharmaceutical Technology Co., LTD

2-Chloro-N-(2,6-dimethylphenyl)acetamide Spectrum

2-Chloro-N-(2,6-dimethylphenyl)acetamide(1131-01-7)MS 2-Chloro-N-(2,6-dimethylphenyl)acetamide(1131-01-7)¹HNMR 2-Chloro-N-(2,6-dimethylphenyl)acetamide(1131-01-7)¹³CNMR 2-Chloro-N-(2,6-dimethylphenyl)acetamide(1131-01-7)IR1 2-Chloro-N-(2,6-dimethylphenyl)acetamide(1131-01-7)IR2 2-Chloro-N-(2,6-dimethylphenyl)acetamide(1131-01-7)Raman

1131-01-7(2-Chloro-N-(2,6-dimethylphenyl)acetamide)Related Search:

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DIETHATYL ETHYL Metolachlor DIMETHACHLOR

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Chloro-2',6'-diMethylacetanilide 2',6'-DiMethyl-2-chloroacetanilide ChloroacetaMido-2,6-xylidine N-(2,6-Xylyl)chloroacetaMide NSC 37260 2-Chloro-N-(2,6-dimethylphenyl)acetamide2-Chloro-N-(2,6-dimethylphenyl)acetamide 2-Chloro-N-(2 6-diMethylphenyl)acetaMide N-(2,6-Dimethylphenyl)chloroacetamide 99% 2-Chloro-N-(2,6-dimethylphenyl)acetamide 2-Chloro-2',6'-acetoxylidide 2',6'-Acetoxylidide, 2-chloro- (8CI) 2-chloro-N-(2,6-dimethylphenyl)ethanamide acetoxylidide N-(2,6-Dimethylphenyl)chloroacetamide 1-Chloroacetylamino-2,6-dimethylbenzene 2',6'-Acetoxylidide, 2-chloro- 2-Chloro-2',6'-dimethylacetanilide 2-Chloroaceto-2,6-xylidide 2-chloro-n-(2,6-dimethylphenyl)-acetamid Acetamide, 2-chloro-N-(2,6-dimethylphenyl)- Chloroacet-2,6-xylide Chloroaceto-2,6-xylidide N-CHLOROACETYL-2,6-DIMETHYLANILINE N-CHLORACETYL-2,6-DIMETHYLANILINE TIMTEC-BB SBB003566 2-CHLORO-2',6'-ACETOXYLIDIDE 2-CHLORO-N-(2,6-DIMETHYLPHENYL)ACETAMIDE AKOS BBS-00000875 CHLOROACETYL-2,6-DIMETHYLANILINE IFLAB-BB F0133-0019 Chloroaceto-2,6-xylidide~alpha-Chloro-2,6-dimethylacetanilide à-chloro-2,6-dimethylacetanilide ALPHA-Chloro-2'',6''-dimethylacetanilide N-(Chloroacetyl)-2,6-diethylaniline 2-Chlorl-N-(2,6-dimethylpheny)acetamide 2-CHLORO-2'',6''-DIMETHYLACETANILIDE (LIDOCAINE) CHLORO ACETYL XYLIDIDE 2-Chloro-N-(2,6-dimethylphenyl)acetamide,98% Lidocaine Impurity H(EP) Lidocaine Impurity 8(Lidocaine EP Impurity H) Lidocaine BP Impurity H JR-8652, 2-Chloro-N-(2,6-dimethylphenyl)acetamide, 97% 2-Chlor-2',6'-dimethylacetanilid Acetamide, 2-chloro-N-(2 Lidocaine Impurity H Reference 2-Chloro-2',6'-dimethylacetanilide > Lidocaine hydrochloride impurity888 LIDOCAINE HYDROCHLORIDE EP IMPURITY H Lidocaine EP Impurity H（2-chloro-N-(2,6-dimethylphenyl)acetamide） Lidocaine Related Compound H (2-Chloro-N-(2,6-dimethylphenyl)acetamide) (1366080) Lidocaine EP Impurity H 10-PHENOXYPHENYLACETIC&ACID Lidocaine USP Related Compound H ChloroAcetyl Xylidine?(N-Chloroacetyl 2,6 Dimethylaniline) 2-Chloro-N-(2,6- dimethylphenyl)acet amide / CAX Base 2-Chloro-N - (2,6-xylenyl) acetamide 2-Chloro-2',6'-dimethylacetanilide, ≥ 98.0% LIDOCAINE EP IMP H