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Description Uses Preparation
Iodotrimethylsilane structure
Chemical Name:
TMIS;CT3610;TMS iodide;IodotrimethyL;Trimethylsilyl io;Iodotrmethylsilane;trimethyiodosilane;Co-Formula CFS-710;IODOTRIMETHYLSILANE;TRIMETHYLIODOSILANE
Molecular Formula:
Formula Weight:
MOL File:

Iodotrimethylsilane Properties

Melting point:
Boiling point:
106 °C(lit.)
1.406 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.471(lit.)
Flash point:
−25 °F
storage temp. 
Clear colorless to reddish
Specific Gravity
Water Solubility 
Moisture & Light Sensitive
Hydrolytic Sensitivity
8: reacts rapidly with moisture, water, protic solvents
CAS DataBase Reference
16029-98-4(CAS DataBase Reference)
NIST Chemistry Reference
EPA Substance Registry System
Silane, iodotrimethyl- (16029-98-4)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H225-H314-H318
Precautionary statements  P260h-P303+P361+P353-P501a-P233-P240-P241+P242+P243-P260-P264-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P403+P235-P405-P501-P210-P280-P305+P351+P338-P310
Hazard Codes  F,C
Risk Statements  11-14-34
Safety Statements  16-26-36/37/39-43-45-25
RIDADR  UN 2924 3/PG 2
WGK Germany  3
HazardClass  3
PackingGroup  II
HS Code  29310095
NFPA 704
3 2

Iodotrimethylsilane price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 195529 Iodotrimethylsilane 97% 16029-98-4 5g $40.3 2021-03-22 Buy
Sigma-Aldrich 195529 Iodotrimethylsilane 97% 16029-98-4 25g $104 2021-03-22 Buy
TCI Chemical I0308 Trimethylsilyl Iodide (stabilized with Aluminum) >95.0%(T) 16029-98-4 5g $28 2021-03-22 Buy
TCI Chemical I0308 Trimethylsilyl Iodide (stabilized with Aluminum) >95.0%(T) 16029-98-4 25g $78 2021-03-22 Buy
Alfa Aesar A12902 Iodotrimethylsilane, 97%, stab. with copper 16029-98-4 25g $95.5 2021-03-22 Buy

Iodotrimethylsilane Chemical Properties,Uses,Production


Iodotrimethylsilane which has a hard acid (Me3Si) -soft base (I) bond displays a strong oxygenophilicity towards ethers, esters, lactones, acetals, and other molecules involving oxygen atom as a functional group.
The use of iodotrimethylsilane as the agent brought about a facile cleavage of the tert-butyl ester, giving the corresponding carboxylic acid in excellent yield.
Iodotrimethylsilane is used for the introduction of trimethylsilyl group in organic synthesis. It is also useful for gas chromatography analysis by converting alcohol into a silyl ether derivative, thereby making it more volatile than the original molecule.
Efficient reagent for cleaving ethers, esters, carbamates, ketals, and lactones.
For the introduction of the TMS group, e.g., TMS enol ethers.
Key reagent for the selective deprotection of an N-Cbz group in the presence of a trimethyltin moiety.
Reagent was recently reported to convert allyl- and benzylphosphotriesters to the corresponding iodides.


Trimethylsilyliodide is a typical blocking agent in pharmaceutical manufacturing, widely used in the syntheses of drugs. It can protect or deprotect functional groups selectively, act as silane blocking agent.


Iodotrimethylsilane, prepared by mixing equimolar amounts of chlorotrimethylsilane and sodium iodide in acetonitrile, reduces various benzylic alcohols to the corresponding phenylalkanes.
Iodotrimethylsilane is a multipurpose reagent used in various organic reactions. It is used for the dealkylation of few compounds like lactones, ethers, acetals, and carbamates and trimethylsilylating agent for the synthesis of silyl imino esters, alkyl and alkenyl silanes, etc. It also acts as a Lewis acid catalyst and as a reducing agent in many organic reactions.

Chemical Properties

Straw liquid

Physical properties

bp 106–109 °C; d 1.406 g cm?3; nD 20 1.4710; fp ?31 °C.


Iodotrimethylsilane can be used as a versatile reagent for the mild dealkylation of ethers, carboxylic esters, lactones, carbamates, acetals, phosphonate and phosphate esters; cleavage of epoxides, cyclopropyl ketones; conversion of vinyl phosphates to vinyl iodides; neutral nucleophilic reagent for halogen exchange reactions, carbonyl and conjugate addition reactions; use as a trimethylsilylating agent for formation of enol ethers, silyl imino esters, and N-silylenamines, alkyl, alkenyl and alkynyl silanes; Lewis acid catalyst for acetal formation, α- alkoxymethylation of ketones, for reactions of acetals with silyl enol ethers and allylsilanes; reducing agent for epoxides, enediones, α-ketols, sulfoxides, and sulfonyl halides; dehydrating agent for oximes.


Iodotrimethylsilane is an efficient reagent for ether, ester, carbamate, ketal, and lactone cleavage.


although more than 20 methods have been reported1 for the preparation of TMS-I, only a few are summarized here. chlorotrimethylsilane undergoes halogen exchange with either lithium iodide in CHCl3 or sodium iodide in MeCN, which allows in situ reagent formation. Alternatively, hexamethyldisilane reacts with iodine at 25–61°Cto afford TMS-I with no byproducts.


Trimethylsilyl iodide reacts under mild conditions in the absence of a catalyst with alkyl fluorides as well as with benzyl and tertiary alkyl chlorides and bromides to give good yields of alkyl iodides and the corresponding trimethylsilyl halides.

Chemical Synthesis

A 250-ml., two-necked, round-bottomed flask equipped with a magnetic stirring bar, an addition funnel for solids, and a reflux condenser bearing a nitrogen inlet is charged with 5.6 g. (0.21 mole) of aluminum powder and 16.2 g. (0.100 mole) of hexamethyldisiloxane and purged with nitrogen. The mixture is stirred and heated with an oil bath at 60° as 50.8 g. (0.200 mole) of iodine is added slowly through the addition funnel over 55 minutes. The bath temperature is raised to ca. 140°, and the mixture is heated under reflux for 1.5 hours. The reflux condenser is removed, and the flask is equipped for distillation at atmospheric pressure. The bath temperature is gradually raised from 140° to 210°, and the clear, colorless distillate is collected, yielding 32.6–35.3 g. (82–88%) of iodotrimethylsilane, b.p. 106–109°.

Purification Methods

Add a little antimony powder and fractionate with this powder in the still. 20 1.470. Stabilise the distillate with 1% wt of Cu powder. [Eaborn J Chem Soc 3077 1950, Beilstein 4 IV 4009.]

Iodotrimethylsilane Preparation Products And Raw materials

Raw materials

Preparation Products

Iodotrimethylsilane Suppliers

Global( 341)Suppliers
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Hubei Langyou International Trading Co., Ltd
13507181894 18874586545 CHINA 124 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886 China 21032 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22607 55
Shanghai Time Chemicals CO., Ltd.
+8618017249410 +86-021-57951555
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View Lastest Price from Iodotrimethylsilane manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-20 Iodotrimethylsilane
US $5.00 / IU 1KG 99% 50 tons Wuhan wingroup Pharmaceutical Co., Ltd
2021-08-31 Iodotrimethylsilane
US $50.00 / KG 1Kg/Bag 99.99% 20 tons/month Wuhan Monad Medicine Tech Co.,LTD
2021-08-12 Iodotrimethylsilane
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

Iodotrimethylsilane Spectrum

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