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Sevoflurane

Sevoflurane
Sevoflurane structure
CAS No.
28523-86-6
Chemical Name:
Sevoflurane
Synonyms
mr6s4;Ultane;R-E 347;Sevoness;Qi Fu Wan;347mmzEbg;Sevofrane;SEVOFLURANE;Sevoflurane (1 mL);1H,1H,3H-Perfluoro(3-methyl-2-oxabutane)
CBNumber:
CB1440979
Molecular Formula:
C4H3F7O
Formula Weight:
200.05
MOL File:
28523-86-6.mol

Sevoflurane Properties

Boiling point:
58°C
Density 
1.505
Flash point:
58°C
storage temp. 
Refrigerator
solubility 
Slightly soluble in water, miscible with ethanol (96 per cent).
form 
neat
Specific Gravity
1.505
Water Solubility 
Slightly miscible with water.
Merck 
14,8475
BRN 
2041023
InChIKey
DFEYYRMXOJXZRJ-UHFFFAOYSA-N
CAS DataBase Reference
28523-86-6(CAS DataBase Reference)
EPA Substance Registry System
Propane,1,1,1,3, 3,3-hexafluoro-2-(fluoromethoxy)- (28523-86-6)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi
Risk Statements  36/37/38-36/38
Safety Statements  26-36/37/39-36/37-23
RIDADR  UN 3334
WGK Germany  3
RTECS  KO0737000
Hazard Note  Irritant
HS Code  29091990
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to..…

Sevoflurane price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0001046 Sevoflurane European Pharmacopoeia (EP) Reference Standard 28523-86-6 y0001046 $179 2018-11-23 Buy
Sigma-Aldrich 1612540 Sevoflurane 28523-86-6 1ml $352.8 2018-11-20 Buy
TCI Chemical F0691 Fluoromethyl 1,1,1,3,3,3-Hexafluoroisopropyl Ether >98.0%(GC) 28523-86-6 5g $186 2018-11-22 Buy
Alfa Aesar L16891 Fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether, 98+% 28523-86-6 5g $195 2018-11-13 Buy
Alfa Aesar L16891 Fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether, 98+% 28523-86-6 1g $57.4 2018-11-13 Buy

Sevoflurane Chemical Properties,Uses,Production

Description

Sevoflurane is a rapidly acting, potent inhalation anesthetic with rapid uptake and and elimination. While somewhat less potent than halothane, sevoflurane does not induce arrhythmias and reportedly has no effect on renal function.

Chemical Properties

Clear, colourless, volatile liquid.

Originator

Baxter (USA)

Uses

antibacterial

Uses

1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane is an volatile anesthetic which inhibited activation of inflammatory neutrophil and granulocyte in human blood during simulated extracorporeal circulati on.

Definition

ChEBI: An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.

brand name

Ultane (Abbott);Sevofrane.

Biological Functions

Sevoflurane (Ultane) is the most recently introduced inhalation anesthetic. It has low tissue and blood solubility, which allows for rapid induction and emergence and makes it useful for outpatient and ambulatory procedures. It has the advantage of not being pungent, a characteristic that permits a smooth inhalation induction, and is particularly useful in pediatric anesthesia.
Hypotension is produced by sevoflurane as systemic vasodilation occurs and cardiac output decreases. Since it does not directly produce tachycardia, it is a useful alternative to consider in patients with myocardial ischemia. However, a concern for reflex-induced tachycardia remains.
Sevoflurane undergoes hepatic biotransformation (about 3% of the inhaled dose), and it is somewhat degraded by conventional CO2 absorbents. The degradation product from the absorbent has been reported to be nephrotoxic, although the report is controversial and not substantiated by more recent studies. Sevoflurane’s actions on skeletal muscle and on vascular regulation within the CNS are similar to those described for the other halogenated hydrocarbon anesthetics.

General Description

Sevoflurane is a volatile, nonpungent, nonflammable, andnonexplosive liquid with a boiling point of 58.6°C. Theblood:gas partition coefficient is 0.65, the oil:gas partitioncoefficient is 50, and the MAC is 2.1%. Sevoflurane reactswith desiccated carbon dioxide adsorbents, to produce compounds(A and B) with known toxicity . The typeof CO2 absorbent used, the temperature of the absorbent,and the duration of exposure can influence the degree towhich sevoflurane breaks down. The major breakdownproduct, compound A, pentafluoroisopropenyl fluoromethylether, (PIFE, C4H2F6O) has been studied extensively.Compound A is nephrotoxic in rats and nonhuman primatesand remains a theoretical risk to humans. As discussedpreviously under the stability of inhaled anesthetics,sevoflurane breakdown by CO2 absorbents generates heatand has resulted in sporadic operating room fires.

Clinical Use

Sevoflurane has been shown to cause epileptic changeson EEGs and case reports of seizures during surgery, especiallyin children, have been reported.

Veterinary Drugs and Treatments

Sevoflurane may be useful in a variety of species when rapid induction and/or rapid recoveries are desired with an inhalational anesthetic.

Sevoflurane Preparation Products And Raw materials

Raw materials

Preparation Products


Sevoflurane Suppliers

Global( 117)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Jinan Shengqi pharmaceutical Co,Ltd
86+15552594168
christine@shengqipharm.com CHINA 553 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20675 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32451 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6373 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 25795 58
Hubei Jusheng Technology Co.,Ltd.
8615527864001
sales@jushengtech.com CHINA 20084 58
Hubei xin bonus chemical co. LTD
8613657299721
sales@xhlchem.com CHINA 17424 58
Lianyungang Xuanyuan Chemical Co., Ltd +86-0518-85415818 18000194506
+86-0518-85415818 18000194506@qq.com China 313 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40274 62

View Lastest Price from Sevoflurane manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-03-21 Sevoflurane
28523-86-6
US $0.00 / KG 1KG 99 10mt Jinan Shengqi pharmaceutical Co,Ltd
2019-02-28 Sevoflurane
28523-86-6
US $0.00-0.00 / kg 1 mkg 99 10MT Jinan Shengqi pharmaceutical Co,Ltd
2018-12-18 Sevoflurane
28523-86-6
US $1.00 / kg 1kg 95%-99% 10kg career henan chemical co

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