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Flunarizine dihydrochloride

Flunarizine dihydrochloride
Flunarizine dihydrochloride structure
CAS No.
30484-77-6
Chemical Name:
Flunarizine dihydrochloride
Synonyms
Mondus;Issium;r14950;Flunarl;kw-3149;Flunagen;Dinaplex;Flugeral;Gradient;Fluxarten
CBNumber:
CB2377940
Molecular Formula:
C26H28Cl2F2N2
Formula Weight:
477.42
MOL File:
30484-77-6.mol

Flunarizine dihydrochloride Properties

Melting point:
188-190?C
storage temp. 
2-8°C
solubility 
chloroform/methanol (9:1): 50 mg/mL, clear, colorless
form 
neat
Merck 
13,4170
BRN 
4284243
CAS DataBase Reference
30484-77-6(CAS DataBase Reference)
FDA UNII
C11102TO53
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312a-P330-P501a-P301+P312+P330
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
RTECS  TK9187000

Flunarizine dihydrochloride price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich F8257 Flunarizine dihydrochloride ≥98% (TLC) 30484-77-6 1g $66.6 2021-03-22 Buy
Sigma-Aldrich F0189900 Flunarizine dihydrochloride European Pharmacopoeia (EP) Reference Standard 30484-77-6 $190 2021-03-22 Buy
Sigma-Aldrich F8257 Flunarizine dihydrochloride ≥98% (TLC) 30484-77-6 10g $392 2021-03-22 Buy
Alfa Aesar J62969 Flunarizine dihydrochloride, 99% 30484-77-6 1g $53.1 2020-06-24 Buy
Cayman Chemical 20385 Flunarizine (hydrochloride) ≥98% 30484-77-6 1g $28 2021-03-22 Buy

Flunarizine dihydrochloride Chemical Properties,Uses,Production

Chemical Properties

White Solid

Originator

Sibelium,Janssen,W. Germany,1977

Uses

antipsychotic, H1 antihistamine

Uses

Calcium channel blocker; fluorinated derivative of Cinnarizine. Vasodilator (cerebral and peripheral). This is the labeled analog.

Manufacturing Process

A mixture of 14.3 parts of di-(p-fluorophenyl)-chloromethane, 10.1 parts of 1- cinnamylpiperazine, 12.7 parts of sodium carbonate, a few crystals of potassium iodide in 200 parts of 4-methyl-2-pentanone is stirred and refluxed for 21 hours. The reaction mixture is cooled and 50 parts of water are added. The organic layer is separated, dried, filtered and evaporated.
The oily residue is dissolved in 480 parts of anhydrous diisopropyl ether. This solution is boiled with activated charcoal, filtered and to the clear filtrate is added an excess of 2-propanol, previously saturated with gaseous hydrogen chloride. The precipitated salt is filtered off and recrystallized from a mixture of 2-propanol and ethanol, yielding 1-cinnamyl-4-(di-p-fluorobenzhydryl) piperazine dihydrochloride, MP 251.5°C.

Therapeutic Function

Vasodilator

Biological Activity

Dual Na + /Ca 2+ channel blocker; a cerebral and peripheral vasodilator. Neuroprotective.

Flunarizine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Flunarizine dihydrochloride Suppliers

Global( 269)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20914 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
010-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26751 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 310 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
faith@widelychemical.com CHINA 743 58
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213
+86 15821988213 info@longyupharma.com China 2473 58

View Lastest Price from Flunarizine dihydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-30 Flunarizine dihydrochloride
30484-77-6
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-11-03 Flunarizine dihydrochloride
30484-77-6
US $10.00 / Kg/Bag 1Kg/Bag 99% 20 Tons Hebei Zhanyao Biotechnology Co. Ltd
2021-11-02 Flunarizine dihydrochloride
30484-77-6
US $80.00-32.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biological Technology Co., Ltd

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