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Meclozine

Meclozine
Meclozine structure
CAS No.
569-65-3
Chemical Name:
Meclozine
Synonyms
Marex;Bonine;Sabari;Subari;Ancolan;Ancolon;Ravelon;Siguran;UCB 170;UCB 5062
CBNumber:
CB2753083
Molecular Formula:
C25H27ClN2
Formula Weight:
390.95
MOL File:
569-65-3.mol

Meclozine Properties

Boiling point:
bp2 230°
Density 
1.0318 (rough estimate)
refractive index 
1.5940 (estimate)
storage temp. 
Sealed in dry,2-8°C
pka
pKa 2.05(H2O,t =25,I=0.0051(NaCl)) (Uncertain)
CAS DataBase Reference
569-65-3(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
3L5TQ84570
NCI Drug Dictionary
Bonine
ATC code
R06AE05,R06AE55
NIST Chemistry Reference
Meclizine(569-65-3)
EPA Substance Registry System
Meclizine (569-65-3)

Meclozine Chemical Properties,Uses,Production

Originator

Antivert,Roerig,US,1957

Uses

Meclizine actively affects the vomiting center and is used for vomiting and diarrhea. Synonyms of this drug are antivert, bonine, lamin, roclizin, and vertol.

Uses

Anti-emetic.

Manufacturing Process

32.3 g of 1-p-chlorobenzhydryl-4-benzyl-piperazine, dissolved in 300 cm3 of alcohol are heated in an autoclave vessel, in the presence of Raney nickel, under a pressure of 100 kg H2, at about 150°C for 6 hours. The catalyst is filtered, the solvent is evaporated and the residue is fractionated under a high vacuum. p-Chlorobenzylhydryl-piperazine (BP 180° to 185°C/1 mm Hg) is isolated with a yield of 75%. Then finely ground NaNH2 is added. The mixture is heated under reflux for 1 hour, the mass is cooled and a molar equivalent of m-methyl benzyl chloride is added.
The solvent is evaporated and the residue is dissolved in chloroform. This solution is washed with a saturated solution of K2CO3 and dried on K2CO3. The solvent is evaporated and the residue is distilled under high vacuum. The product of the condensation distills near 230°C at 2 mm Hg pressure and the corresponding dihydrochloride melts at 217° to 224°C.

brand name

Antivert (Pfizer);Ancoloxine;Bonamina;Bonamine;Calmonal;Chiclida;Cobinamide;Diadril;Dradril;Duremesan;Itinerol;Mecazine;Navicalm;Neo-istafenc;Neo-istafene;Peremesin;Postafene;Premesin;Rovert-m;Ru-vert-m;Sea-leg;Supermesin;Superminal;Suprimal;Taizerl;V-cline;Veritab;Vertizine;Vomaxine;Vomisseis.

Therapeutic Function

Antinauseant

World Health Organization (WHO)

Meclozine, an antihistamine with antiemetic activity, was introduced in 1953 for the treatment of nausea. The action taken in Indonesia in 1963 resulted from concern regarding its possible teratogenic potential. Subsequent epidemiological studies have been widely accepted, however, as dispelling this suspicion. Meclozine remains widely available in both prescription only and over-the-counter preparations and in some countries the licensed indications include management of nausea of pregnancy.

Chemical Synthesis

Meclizine, 1-[(4-chlorphenyl)methyl]-4-[(3-methylphenyl)phenyl]piperazine (16.1.16), is synthesized by reductive amination of a mixture of 3-methylbenzaldehyde with 1-(4-chlorbenzhydryl)piperazine using hydrogen over Raney nickel.

Meclozine Preparation Products And Raw materials

Raw materials

Preparation Products


Meclozine Suppliers

Global( 56)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47498 58
career henan chemical co
13203830695 0086-371-86658258
0086-371-86658258 factory@coreychem.com CHINA 29864 58
Shaanxi Dideu Medichem Co. Ltd
13772537765
029-88380327 1010@dideu.com CHINA 3993 58
SIMAGCHEM CORP
13806087780 +86 13806087780
shaobowang@simagchem.com CHINA 17556 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671
0551-65418697 sales@tnjchem.com CHINA 37441 58
Shaanxi Dideu Medichem Co. Ltd
18192503167 +86-29-89586680
+86-29-88380327 1005@dideu.com CHINA 9938 58
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 30013 58
Xi'an ZB Biotech Co.,Ltd

sales03@xazbbio.com CHINA 1128 58

View Lastest Price from Meclozine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-20 Meclozine
569-65-3
US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
2021-06-17 Meclozine USP/EP/BP
569-65-3
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
2019-12-26 Meclozine
569-65-3
US $1.00 / KG 1KG 99% 1000KGS Career Henan Chemical Co

569-65-3(Meclozine)Related Search:


  • UCB 5052
  • UCB 5062
  • Vomisseis
  • Vomissels
  • 1-(p-Chloro-a-phenylbenzyl)-4-(m-methylbenzyl)piperazine
  • mecilizine
  • NSC 169189
  • Piperazine, 1-(p-chloro-a-phenylbenzyl)-4-(m-methylbenzyl)- (6CI, 8CI)
  • Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]- (9CI)
  • MECLIZINE
  • MECLOZINE
  • 1-[(4-chlorophenyl)-phenyl-methyl]-4-[(3-methylphenyl)methyl]piperazine
  • 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)-piperazin 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)piperazine 1-(p-chlorobenzhydryl)-4-(m-methylbenzyl)diethylenediamine 1-(p-chlorobenzhydryl)-4-(m-methylbenzyl)piperazine 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine 1-p-chlorobenzhydryl-4-m-methylbenzylpiperazine ancolan antivert
  • 1-(P-CHLORO-ALPHA-PHENYLBENZYL)-4-(M-METHYLBENZYL)-PIPERAZIN
  • 1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)diethylenediami
  • 2-Methyl Meclizine IsoMer
  • 1-(p-Chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)piperazine
  • 1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)diethylenediamine
  • 1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)piperazine
  • 1-[(4-Chlorophenyl)(phenyl)methyl]-4-(3-methylbenzyl)piperazine
  • Ancolan
  • Ancolon
  • Bonadettes
  • Bonadoxin
  • Bonine
  • Calmonal
  • Chiclida
  • Histamethine
  • Histamethizine
  • Histametizine
  • Histametizyne
  • Itinerol
  • Marex
  • Monamine
  • Navicalm
  • Neo-Istafene
  • neo-Suprimal
  • neo-Suprimel
  • Parachloramine
  • Peremesin
  • Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)-
  • Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-
  • Postafene
  • Ravelon
  • Sabari
  • Sea-Legs
  • Siguran
  • Subari
  • Suprimal
  • Travelon
  • U. C. B. 5062
  • UCB 170
  • Meclozine USP/EP/BP
  • 569-65-3
  • C25H27ClN2
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