3-Thiopheneboronic acid
- CAS No.
- 6165-69-1
- Chemical Name:
- 3-Thiopheneboronic acid
- Synonyms
- THIOPHEN-3-YLBORONIC ACID;THIOPHENE-3-BORONIC ACID;AKOS BRN-0047;3-thienoborate;3-Boronothiophene;TIMTEC-BB SBB004244;RARECHEM AH PB 0232;3-Thiopheneboronica;3-ThiopheneBoricAcid;3-THIENYLBORONIC ACID
- CBNumber:
- CB2755805
- Molecular Formula:
- C4H5BO2S
- Molecular Weight:
- 127.96
- MDL Number:
- MFCD00151851
- MOL File:
- 6165-69-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3-Thienylboronic acid ≥95.0% | 436844 | 1g | $40 |
| 3-Thienylboronic acid ≥95.0% | 436844 | 5g | $81.1 |
| 3-Thiopheneboronic Acid (contains varying amounts of Anhydride) | T1975 | 1g | $30 |
| 3-Thiopheneboronic Acid (contains varying amounts of Anhydride) | T1975 | 5g | $85 |
| 3-ThiopheneboronicAcid | T344640 | 1g | $85 |
| More product size | |||
| Melting point | 164-169 °C (lit.) |
|---|---|
| Boiling point | 287.9±32.0 °C(Predicted) |
| Density | 1.32±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | Powder |
| pka | 8.25±0.10(Predicted) |
| color | Almost white to grayish |
| BRN | 113573 |
| InChI | InChI=1S/C4H5BO2S/c6-5(7)4-1-2-8-3-4/h1-3,6-7H |
| InChIKey | QNMBSXGYAQZCTN-UHFFFAOYSA-N |
| SMILES | C1SC=CC=1B(O)O |
| CAS DataBase Reference | 6165-69-1(CAS DataBase Reference) |
| UNSPSC Code | 12352103 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-37/39-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | IRRITANT, IRRITANT-HARMFUL, KEEP COLD | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3-Thiopheneboronic acid price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 436844 | 3-Thienylboronic acid ≥95.0% | 6165-69-1 | 1g | $40 | 2026-04-30 | Buy |
| Sigma-Aldrich | 436844 | 3-Thienylboronic acid ≥95.0% | 6165-69-1 | 5g | $81.1 | 2026-04-30 | Buy |
| TCI Chemical | T1975 | 3-Thiopheneboronic Acid (contains varying amounts of Anhydride) | 6165-69-1 | 1g | $30 | 2026-04-30 | Buy |
| TCI Chemical | T1975 | 3-Thiopheneboronic Acid (contains varying amounts of Anhydride) | 6165-69-1 | 5g | $85 | 2026-04-30 | Buy |
| TRC | T344640 | 3-ThiopheneboronicAcid | 6165-69-1 | 1g | $85 | 2021-12-16 | Buy |
3-Thiopheneboronic acid Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powder
Uses
3-Thiopheneboronic Acid is used in the synthesis of porphyrins as inhibitiors of telomerase. It is also used to prepare 1,4-disubstituted imidazoles as potential antibacterial agents.
Uses
suzuki reaction
Synthesis
872-31-1
6165-69-1
General procedure for the synthesis of 3-thiophene boronic acid from 3-bromothiophene: Triphenylphosphine (0.131 g, 0.5 mmol, 20 mol%), p-iodoiodobenzene (0.585 g, 2.5 mmol), and triethylamine (1.78 mL, 12.5 mmol) were added sequentially to a 50 mL round-bottomed flask (equipped with a side arm, a condenser, and a stir bar). The reaction system was degassed by alternating vacuum and argon filling three times. Palladium dichloride (0.023 g, 0.13 mmol, 5 mol%) was added under positive argon pressure. After stirring for 15 minutes at room temperature, diisopropylaminoborane (5 mL, 1 M THF solution, 5 mmol) was added and the reaction mixture was again degassed by alternating vacuum and argon filling three times. The reaction solution was heated to reflux and kept at reflux for 12 hours. Upon completion of the reaction, the reaction solution was cooled to 0 °C and 6 mL of methanol was slowly added (note: this is an exothermic reaction, which releases hydrogen). After stirring for 15 minutes, all solvent was removed by distillation under reduced pressure to give a black solid. The solid was dissolved in 3M sodium hydroxide solution (8 mL) and subsequently washed with hexane (3 x 10 mL). The aqueous layer was cooled to 0°C (ice bath) and acidified with concentrated hydrochloric acid to pH ≤ 1, at which point 3-thiopheneboronic acid precipitated as a white solid. The aqueous layer was extracted with ether (3 x 10 mL), the organic phases were combined, dried with magnesium sulfate and filtered. Finally, the solvent was removed by distillation under reduced pressure to obtain 3-thiopheneboronic acid in white solid form.
References
[1] Journal of Medicinal Chemistry, 2005, vol. 48, # 1, p. 224 - 239
[2] Organic Letters, 2011, vol. 13, # 17, p. 4479 - 4481
[3] Journal of Organic Chemistry, 2013, vol. 78, # 13, p. 6427 - 6439
[4] Patent: US6342610, 2002, B2. Location in patent: Page column 77
[5] Tetrahedron, 2011, vol. 67, # 3, p. 576 - 583
3-Thiopheneboronic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
1of3
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| BAYNOE CHEM CO.,LTD | +86-21-34783353 +8615000719740 | baynoe@baynoe.com | CHINA | 934 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3982 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5742 | 58 |
View Lastest Price from 3-Thiopheneboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | 3-Thiopheneboronic acid
6165-69-1
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2019-07-06 | 3-Thiopheneboronic acid
6165-69-1
|
US $1.00 / KG | 1G | 98% | 1000KG | Career Henan Chemical Co |
-
- 3-Thiopheneboronic acid
6165-69-1
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 3-Thiopheneboronic acid
6165-69-1
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
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