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AcesulfaMe

AcesulfaMe
AcesulfaMe structure
CAS No.
55589-62-3
Chemical Name:
AcesulfaMe
Synonyms
sunett;SUNETTE;SWEET ONE;acesulfame;Ccris 1032;ACESULFAME K;Acesulfaml-K;Acessulfame-K;ACESULPHAME-K;ACESULFAME-K(P)
CBNumber:
CB3224119
Molecular Formula:
C4H5KNO4S
Formula Weight:
202.25
MOL File:
55589-62-3.mol

AcesulfaMe Properties

Melting point:
229-232°C (dec.)
Density 
(solid) 1.81 g/cm3; d (bulk) 1.1-1.3 kg/dm3
storage temp. 
0-6°C
solubility 
Soluble in water, very slightly soluble in acetone and in ethanol (96 per cent).
form 
neat
Water Solubility 
almost transparency
Merck 
14,37
BRN 
3637857
CAS DataBase Reference
55589-62-3(CAS DataBase Reference)
EPA Substance Registry System
1,2,3-Oxathiazin- 4(3H)-one, 6-methyl-, 2,2-dioxide, potassium salt(55589-62-3)

SAFETY

Risk Statements  36/37/38
Safety Statements  26-36/37/39
WGK Germany  1
RTECS  RP4489165
Toxicity LD50 in rats (mg/kg): 7431 orally, 2243 i.p. (Mayer, Kemper)

AcesulfaMe price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 04054 Acesulfame K for food analysis, ≥99.0% 55589-62-3 25g $67.5 2018-11-22 Buy
Sigma-Aldrich 04054 Acesulfame K for food analysis, ≥99.0% 55589-62-3 100g $187 2018-11-22 Buy
TCI Chemical A1490 Acesulfame K >98.0%(T) 55589-62-3 25g $39 2018-11-22 Buy
TCI Chemical A1490 Acesulfame K >98.0%(T) 55589-62-3 100g $117 2018-11-22 Buy
Sigma-Aldrich A0070000 Acesulfame potassium European Pharmacopoeia (EP) Reference Standard 55589-62-3 a0070000 $179 2018-11-23 Buy

AcesulfaMe Chemical Properties,Uses,Production

Chemical Properties

White to Off-White Solid

Chemical Properties

Acesulfame potassium occurs as a colorless to white-colored, odorless, crystalline powder with an intensely sweet taste.

Uses

Potassium salt as sweetener for foods, cosmetics.

Uses

'New generation', heat-stable sweetener that has not been suspected to cause cancer nor be genotoxic. Allelic variation of the Tas1r3 gene affects behavioral taste responses to this molecule, suggesting that it is a T1R3 receptor ligand.

Production Methods

Acesulfame potassium is synthesized from acetoacetic acid tertbutyl ester and fluorosulfonyl isocyanate. The resulting compound is transformed to fluorosulfonyl acetoacetic acid amide, which is then cyclized in the presence of potassium hydroxide to form the oxathiazinone dioxide ring system. Because of the strong acidity of this compound, the potassium salt is produced directly.
An alternative synthesis route for acesulfame potassium starts with the reaction between diketene and amidosulfonic acid. In the presence of dehydrating agents, and after neutralization with potassium hydroxide, acesulfame potassium is formed.

Pharmaceutical Applications

Acesulfame potassium is used as an intense sweetening agent in cosmetics, foods, beverage products, table-top sweeteners, vitamin and pharmaceutical preparations, including powder mixes, tablets, and liquid products. It is widely used as a sugar substitute in compounded formulations,and as a toothpaste sweetener.
The approximate sweetening power is 180–200 times that of sucrose, similar to aspartame, about one-third as sweet as sucralose, one-half as sweet as sodium saccharin, and about 4-5 times sweeter than sodium cyclamate.It enhances flavor systems and can be used to mask some unpleasant taste characteristics.

Safety

Acesulfame potassium is widely used in beverages, cosmetics, foods, and pharmaceutical formulations, and is generally regarded as a relatively nontoxic and nonirritant material. Pharmacokinetic studies have shown that acesulfame potassium is not metabolized and is rapidly excreted unchanged in the urine. Long-term feeding studies in rats and dogs showed no evidence to suggest acesulfame potassium is mutagenic or carcinogenic.
The WHO has set an acceptable daily intake for acesulfame potassium of up to 15 mg/kg body-weight.The Scientific Committee for Foods of the European Union has set a daily intake value of up to 9 mg/kg of body-weight.
LD50 (rat, IP): 2.2 g/kg
LD50 (rat, oral): 6.9–8.0 g/kg

storage

Acesulfame potassium possesses good stability. In the bulk form it shows no sign of decomposition at ambient temperature over many years. In aqueous solutions (pH 3.0–3.5 at 208℃) no reduction in sweetness was observed over a period of approximately 2 years. Stability at elevated temperatures is good, although some decomposition was noted following storage at 408℃ for several months. Sterilization and pasteurization do not affect the taste of acesulfame potassium.
The bulk material should be stored in a well-closed container in a cool, dry place and protected from light.

Regulatory Status

Included in the FDA Inactive Ingredients Database for oral and sublingual preparations. Included in the Canadian List of Acceptable Non-medicinal Ingredients. Accepted for use in Europe as a food additive. It is also accepted for use in certain food products in the USA and several countries in Central and South America, the Middle East, Africa, Asia, and Australia.

AcesulfaMe Preparation Products And Raw materials

Raw materials

Preparation Products


AcesulfaMe Suppliers

Global( 258)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21935 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20676 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32452 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 661 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1815 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1019 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 25796 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23958 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20084 58

View Lastest Price from AcesulfaMe manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-21 6-Methyl-1,2,3-oxathiazin-4(3H)-one 2,2-dioxide potassium salt
55589-62-3
US $1.00 / kg 1g 99% 100KG career henan chemical co
2019-04-22 Acesulfame K
55589-62-3
US $10.00 / Kg 1Kg 99% 5000kg/month Hebei Chisure Biotechnology Co., Ltd.

AcesulfaMe Spectrum


55589-62-3(AcesulfaMe)Related Search:


  • acesulfame
  • Acessulfame-K
  • 1,2,3-oxathiazin-4(3h)-one,6-methyl-,2,2-dioxide,potassiumsalt
  • 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-one2,2-dioxidepotassiumsalt
  • potassiumacesulfame
  • Potassiumsaltof6-methyl-1,2,3-oxathiazin-4(3H)-one-2,2-dioxide
  • sunett
  • Acesulfamum Kalicum
  • ACESULFAME-K FCC 99-101%
  • 6-METHYL-1,2,3-OXATHIAZIN-4(3H)-ONE 2,2-DIOXIDE POTASSIUM SALT
  • ACESULFAME K
  • ACESULFAME POTASSIUM SALT
  • ACESULFAME POTASSIUM
  • ACESULFAME-K(P)
  • AcesulfaMe PotassiuM,NF
  • PotassiuM 6-Methyl-4-oxo-4H-1,2,3-oxathiazin-3-ide 2,2-dioxide
  • 1,2,3-Oxathiazin-4(3H)-one, 6-methyl-, 2,2-dioxide, potassium salt (1:1)
  • SUNETTE
  • SWEET ONE
  • RARECHEM AM UC 0205
  • POTASSIUM 6-METHYL-1,2,3-OXATHIAZIN-4(3H)-ONE 2,2-DIOXIDE
  • 55589-62-3
  • C4H5KNO4S
  • C4H4SNKO4
  • C4H4SKNO4
  • C4H4KNSO4
  • ACESULFAME POTASSIUM(AK)
  • ACESULPHAME-K
  • POTASSIUMACESULFAMEK
  • ASPARTAMEACESULPHAMESALT
  • ACESULPHAMEPOTASSIUM
  • 6-Methyl-3,4-dihydro-1,2,3-oxathiazin-4-on-2,2-dioxid, Kaliumsalz
  • Blended sweetener of acesulfame-kwith aspartame
  • Acesulfaml-K
  • 3,4-Dihydro-6-methyl-3-potassio-4-oxo-1,2,3-oxathiazine 2,2-dioxide
  • 3,4-Dihydro-6-methyl-4-oxo-3-potassio-1,2,3-oxathiazine 2,2-dioxide
  • Ccris 1032
  • Einecs 259-715-3
  • Acesulfame K,6-Methyl-1,2,3-oxathiazin-4(3H)-one 2,2-dioxide potassium salt
  • Acesulfame Potassium (200 mg)
  • 6-Methyl-1,2,3-oxathiazin-4(3H)-one 2,2-Dioxide Potassium Salt Potassium 6-Methyl-1,2,3-oxathiazin-4(3H)-one 2,2-Dioxide
  • C4H4NO4KS
  • C4H4NO4SKC4H4KNO4S
  • C4H4KNO4S
  • C4H5NO4SK
  • -
  • Chromatography
  • Analytical Standards
  • Analytical Chromatography Product Catalog
  • Food & Feed ADDITIVES
  • K (Potassium) Compounds (excluding simple potassium salts)
  • Classes of Metal Compounds
  • Typical Metal Compounds
  • Sweeteners
  • Food & Flavor Additives
  • Heterocycles
  • Sulfur & Selenium Compounds
  • Typical Metal Compounds
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