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Acesulfame potassium

Acesulfame potassium
Acesulfame potassium structure
CAS No.
55589-62-3
Chemical Name:
Acesulfame potassium
Synonyms
Ansai;AcesuL;sunett;SUNETTE;Ak Candy;SWEET ONE;Ccris 1032;acesulfame;Acesulfaml-K;ACESULFAME K
CBNumber:
CB3224119
Molecular Formula:
C4H4KNO4S
Formula Weight:
201.24
MOL File:
55589-62-3.mol

Acesulfame potassium Properties

Melting point:
229-232°C (dec.)
Density 
(solid) 1.81 g/cm3; d (bulk) 1.1-1.3 kg/dm3
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Soluble in water, very slightly soluble in acetone and in ethanol (96 per cent).
form 
neat
color 
White crystalline solid
Odor
odorless with sweet taste
Water Solubility 
almost transparency
Merck 
14,37
BRN 
3637857
CAS DataBase Reference
55589-62-3(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS)
ACESULFAME POTASSIUM
EWG's Food Scores
1
FDA UNII
23OV73Q5G9
EPA Substance Registry System
Acesulfame-potassium (55589-62-3)
SAFETY
  • Risk and Safety Statements
Risk Statements  36/37/38
Safety Statements  26-36/37/39
WGK Germany  1
RTECS  RP4489165
HS Code  2934990002
Toxicity LD50 in rats (mg/kg): 7431 orally, 2243 i.p. (Mayer, Kemper)

Acesulfame potassium price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 04054 Acesulfame K for food analysis, ≥99.0% 55589-62-3 25g $71.5 2020-08-18 Buy
Sigma-Aldrich A0070000 Acesulfame potassium European Pharmacopoeia (EP) Reference Standard 55589-62-3 $190 2021-03-22 Buy
Sigma-Aldrich 04054 Acesulfame K for food analysis, ≥99.0% 55589-62-3 100g $198 2020-08-18 Buy
TCI Chemical A1490 Acesulfame K >98.0%(T) 55589-62-3 25g $43 2021-03-22 Buy
TCI Chemical A1490 Acesulfame K >98.0%(T) 55589-62-3 100g $126 2021-03-22 Buy

Acesulfame potassium Chemical Properties,Uses,Production

Chemical Properties

White to Off-White Solid

Chemical Properties

Acesulfame potassium occurs as a colorless to white-colored, odorless, crystalline powder with an intensely sweet taste.

Originator

Acesulfame Potassium ,Hoechst

History

Acesulfame-K, the potassium salt of acesulfame, is a sweetener that resembles saccharin in structure and taste profile. 5,6-Dimethyl-1,2,3-oxathiazine-4(3H)-one 2,2-dioxide, the first of many sweet compounds belonging to the dihydrooxathiazinone dioxide class, was discovered accidentally in 1967. From these many sweet compounds, acesulfame was chosen for commercialization. To improve water solubility, the potassium salt was made. Acesulfame-K (Sunett) was approved for dry product use in the United States in 1988 and in Canada in October, 1994. In 2003, acesulfame-K was approved as a general purposes sweetener by the FDA.

Uses

'New generation', heat-stable sweetener that has not been suspected to cause cancer nor be genotoxic. Allelic variation of the Tas1r3 gene affects behavioral taste responses to this molecule, suggesting that it is a T1R3 receptor ligand.

Uses

Potassium salt as sweetener for foods, cosmetics.

Uses

Acesulfame-K is the potassium salt of 6-methyl-l,2,3-oxathiazin-4(3H)- one-2,2-dioxide. This sweetener was discovered in Germany and was first approved by the FDA in 1988 for use as a nonnutritive sweetener. The complex chemical name of this substance led to the creation of the trademark common name, acesulfame-K, which is based on its following relationships to acetocetic acid and sulfanic acid, and to its potassium salt nature.
Acesulfame-K is 200 times as sweet as sugar and is not metabolized and is thus noncaloric. It is exceptionally stable at elevated temperatures encountered in baking, and it is also stable in acidic products, such as carbonated soft drinks. It has a synergistic effect when mixed with other low-calorie sweetners, such as aspartame. Common applications of acesulfame-K are table uses, chewing gums, beverages, foods, bakery products, confectionary, oral hygiene products, and pharmaceuticals.

Production Methods

Acesulfame potassium is synthesized from acetoacetic acid tertbutyl ester and fluorosulfonyl isocyanate. The resulting compound is transformed to fluorosulfonyl acetoacetic acid amide, which is then cyclized in the presence of potassium hydroxide to form the oxathiazinone dioxide ring system. Because of the strong acidity of this compound, the potassium salt is produced directly.
An alternative synthesis route for acesulfame potassium starts with the reaction between diketene and amidosulfonic acid. In the presence of dehydrating agents, and after neutralization with potassium hydroxide, acesulfame potassium is formed.

Production Methods

The principal commercial process for acesulfame-K is depicted below: 图

Manufacturing Process

80 g (1.096 mol) of dimethylethylamine were added drop-wise, with cooling, to 80 g (0.825 mol) of sulfamic acid suspended in 500 ml of glacial acetic acid. When dissolution was complete, 80 ml (1.038 mol) of diketene were added, while cooling at 25°-35°C. After 16 hours, the mixture was evaporated and the residue was stirred with acetone, whereupon crystallization of dimethylethylammonium acetoacetamide-N-sulfonate took place. Yield: 110 g (43%), melting point 73°-75°C.
12.7 g (50 mmol) of dimethylethylammonium acetoacetamide-N-sulfonate in 110 ml of methylene chloride were added drop-wise to 8 ml (200 mmol) of liquid SO3 in 100 ml of CH2Cl2 at -30°C, stirring vigorously, within 60 minutes. 30 minutes later, 50 ml of ethyl acetate and 50 g of ice were added to the solution. The organic phase was separated off, and the aqueous phase was extracted twice more with ethyl acetate. The combined organic phases were dried over sodium sulfate, evaporated and the residue was dissolved in methanol. On neutralization of the solution with methanolic KOH, the potassium salt of 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-one 2,2-dioxide precipitated out. Yield: 7.3 g (73%). The product was detected by thinlayer chromatography; the structure of it was confirmed with IR spectrum.

Therapeutic Function

Pharmaceutic aid

Pharmaceutical Applications

Acesulfame potassium is used as an intense sweetening agent in cosmetics, foods, beverage products, table-top sweeteners, vitamin and pharmaceutical preparations, including powder mixes, tablets, and liquid products. It is widely used as a sugar substitute in compounded formulations,and as a toothpaste sweetener.
The approximate sweetening power is 180–200 times that of sucrose, similar to aspartame, about one-third as sweet as sucralose, one-half as sweet as sodium saccharin, and about 4-5 times sweeter than sodium cyclamate.It enhances flavor systems and can be used to mask some unpleasant taste characteristics.

Safety Profile

When heated to decompositionemits toxic fumes of SOx.

Safety

Acesulfame potassium is widely used in beverages, cosmetics, foods, and pharmaceutical formulations, and is generally regarded as a relatively nontoxic and nonirritant material. Pharmacokinetic studies have shown that acesulfame potassium is not metabolized and is rapidly excreted unchanged in the urine. Long-term feeding studies in rats and dogs showed no evidence to suggest acesulfame potassium is mutagenic or carcinogenic.
The WHO has set an acceptable daily intake for acesulfame potassium of up to 15 mg/kg body-weight.The Scientific Committee for Foods of the European Union has set a daily intake value of up to 9 mg/kg of body-weight.
LD50 (rat, IP): 2.2 g/kg
LD50 (rat, oral): 6.9–8.0 g/kg

storage

Acesulfame potassium possesses good stability. In the bulk form it shows no sign of decomposition at ambient temperature over many years. In aqueous solutions (pH 3.0–3.5 at 208℃) no reduction in sweetness was observed over a period of approximately 2 years. Stability at elevated temperatures is good, although some decomposition was noted following storage at 408℃ for several months. Sterilization and pasteurization do not affect the taste of acesulfame potassium.
The bulk material should be stored in a well-closed container in a cool, dry place and protected from light.

Regulatory Status

Included in the FDA Inactive Ingredients Database for oral and sublingual preparations. Included in the Canadian List of Acceptable Non-medicinal Ingredients. Accepted for use in Europe as a food additive. It is also accepted for use in certain food products in the USA and several countries in Central and South America, the Middle East, Africa, Asia, and Australia.

Acesulfame potassium Preparation Products And Raw materials

Raw materials

Preparation Products


Acesulfame potassium Suppliers

Global( 338)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 3001 55
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967
kaia@neputrading.com CHINA 1011 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5382 58
hdzhl biotechnology co., ltd
86-13032617415
sales@luchibiology.com CHINA 1275 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58

View Lastest Price from Acesulfame potassium manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-09-29 Acesulfame potassium
55589-62-3
US $0.00 / Kg/Drum 25KG 99.0%~101.0%; FCC9/EP8 100tons/month WUHAN FORTUNA CHEMICAL CO., LTD
2021-08-26 Acesulfame potassium
55589-62-3
US $1.90 / KG 1KG 99% 10 ton Hebei Crovell Biotech Co Ltd
2021-07-13 Acesulfame potassium
55589-62-3
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

Acesulfame potassium Spectrum


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