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L(+)-Arginine

Indications and Usage Mechanisms of Action Adverse reactions Toxicity Level Acute Toxicity Flammability Characteristics Handling Extinguishers
L(+)-Arginine
L(+)-Arginine structure
CAS No.
74-79-3
Chemical Name:
L(+)-Arginine
Synonyms
ARG;ABLL;ABL2;L-ARG;nmsyxsn;FLJ41441;FLJ31718;FLJ22224;AGRININE;L-ARG-OH
CBNumber:
CB9226645
Molecular Formula:
C6H14N4O2
Formula Weight:
174.2
MOL File:
74-79-3.mol

L(+)-Arginine Properties

Melting point:
222 °C (dec.) (lit.)
alpha 
27.1 º (c=8, 6N HCl)
Boiling point:
305.18°C (rough estimate)
Density 
1.2297 (rough estimate)
refractive index 
27 ° (C=8, 6mol/L HCl)
FEMA 
3819 | L-ARGININE
storage temp. 
2-8°C
solubility 
H2O: 100 mg/mL
form 
powder
pka
1.82, 8.99, 12.5(at 25℃)
color 
white
PH
10.5-12.0 (25℃, 0.5M in H2O)
PH Range
10.5 - 12
optical activity
[α]20/D +27°, c = 8 in 6 M HCl
Water Solubility 
148.7 g/L (20 ºC)
Sensitive 
Air Sensitive
λmax
λ: 260 nm Amax: ≤0.2
λ: 280 nm Amax: ≤0.1
Merck 
14,780
JECFA Number
1438
BRN 
1725413
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
ODKSFYDXXFIFQN-BYPYZUCNSA-N
Substances Added to Food (formerly EAFUS)
L-ARGININE
FDA 21 CFR
172.320
CAS DataBase Reference
74-79-3(CAS DataBase Reference)
NCI Dictionary of Cancer Terms
L-arginine
FDA UNII
908KNZ02WL
NIST Chemistry Reference
L-Arginine(74-79-3)
EPA Substance Registry System
L-Arginine (74-79-3)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xn,T
Risk Statements  36-36/37/38-20/21/22-61
Safety Statements  24/25-36-26-45-53-39
WGK Germany  3
RTECS  CF1934200
10-23
TSCA  Yes
HazardClass  IRRITANT
HS Code  29252000
Toxicity cyt-grh-par 100 mmol/L IJEBA6 24,460,86
NFPA 704
0
1 0

L(+)-Arginine price More Price(42)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 11009 L-Arginine BioUltra, ≥99.5% (NT) 74-79-3 25g-f $33.9 2020-08-18 Buy
Sigma-Aldrich 11009 L-Arginine BioUltra, ≥99.5% (NT) 74-79-3 25 g $35.1 2021-03-22 Buy
Sigma-Aldrich 11009 L-Arginine BioUltra, ≥99.5% (NT) 74-79-3 100 g $81.2 2021-03-22 Buy
Sigma-Aldrich W381920 L-Arginine natural, FCC, FG 74-79-3 1 kg $89.2 2021-03-22 Buy
Sigma-Aldrich W381920 L-Arginine natural, FCC, FG 74-79-3 5 kg $315 2021-03-22 Buy

L(+)-Arginine Chemical Properties,Uses,Production

Indications and Usage

Odorless, slightly bitter. Easily soluble in water (solubility in 0℃ water is 83g/L, solubility in 50℃ water is 400g/L), very slightly soluble in ethanol, insoluble in ether; pI6.0; loses its 2-molecule water crystal when heated to 105℃, darkens in color at 230℃, disintegrates at 244℃; its aqueous solution has maximum absorption at 205nm (1gε3.28).
L-Arginine is an encoding amino acid in protein synthesis and is one of the 8 essential amino acids in the human body. The body needs it for many different functions. Taking L-Arginine supplements can treat certain diseases such as congestive heart failure and cystitis. L-Arginine can also act as seasoning for nutrient supplements and food additives. L-Arginine can undergo a heat reaction with sugar (amino-carbonyl reaction) to obtain a unique fragrance, GB 2760-2001, an approved food spice. As an amino acid drug, L-Arginine can be used as pharmaceutical raw material and is an important ingredient in amino acid infusions and integrated amino acid preparations. It is also a crucial amino acid in maintaining infant growth and maturation.

Mechanisms of Action

L-Arginine can stimulate the human body to release certain chemicals such as insulin and human growth hormone. It can also clear ammonia in the body and promote the healing of wounds. The human body also needs it to produce sarcosine. Decomposing L-Arginine produces nitric oxide, which can expand blood vessels and increase blood flow. L-Arginine is an intermediate metabolite in the orthinine cycle and promotes the conversion of ammonia to urea, thus lowering the blood concentration of ammonia. L-Arginine is also an important part of sperm protein and can promote spermatogenesis and provide energy for sperm movement. Additionally, intravenous arginine can stimulate the pituitary to release growth hormone and can be used to test pituitary functions.

Adverse reactions

Abdominal pain, diarrhea, gout and bloating. There may also be increased severity in herpes breakouts and increased effects of antihypertensive drugs, resulting in a lower blood pressure than expected, which may cause hypertensive patients to experience dizziness and fainting.

Toxicity Level

Moderate

Acute Toxicity

Reference data: abdominal cavity – large rat LD50: 3793 mg/kg.

Flammability Characteristics

Flammable. Burning produces toxic nitrogen oxide smoke.

Handling

Store in ventilated, cool and dry area.

Extinguishers

Dry powder, foam, sand, carbon dioxide, water mist.

Chemical Properties

Arginine is a diaminomonocarboxylic acid. The nonessential amino acid, arginine, is a urea cycle amino acid and a precursor for the neurotransmitter nitric oxide, which plays a role in the regulation of the brain’s system of dilation and constriction of small blood vessels. It is strongly alkaline and its water solutions absorb carbon dioxide from the air (FCC, 1996). Functionality in foods includes, but is not limited to, nutrient and dietary supplement

Chemical Properties

White crystalline powder

Occurrence

Reported present in cheese, chocolate, eggs, meat, nuts and other products.

Uses

Amino acid; nutrient.

Definition

ChEBI: An L-alpha-amino acid that is the L-isomer of arginine.

Aroma threshold values

Detection at 100%, faint.

Taste threshold values

Taste characteristics at 1000 ppm: hint of sourness.

Safety Profile

Mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx.

Chemical Synthesis

Enzymatically, arginine is formed in two reactions from citrulline. The first reaction (citrulline + succinate) is catalyzed by the enzyme arginosuccinate synthetase. It is ATP dependent and with the formation of a new C–N bond in the gaunidino group of arginosuccinate, water is removed and ATP is hydrolyzed. The second reaction is catalyzed by arginine synthetase and involves the scission of arginosuccinate with the formation of arginine and fumaric acid.

Purification Methods

S-Arginine crystallises from H2O as the dihydrate and as plates from EtOH. It also crystallises from 66% EtOH. Its solubility in H2O is 15% at 21o. Its isoelectric point is at pH 10.76. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 1841 1961, Beilstein 4 IV 817.]

L(+)-Arginine Preparation Products And Raw materials

Raw materials

Preparation Products


L(+)-Arginine Suppliers

Global( 780)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Huaian yishu technology co.,ltd
13852390259 86-0517-85883738
sales@yishuchem.com CHINA 53 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Shanghai Time Chemicals CO., Ltd.
+8618017249410 +86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26734 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 3001 55
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967
kaia@neputrading.com CHINA 1011 58

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View Lastest Price from L(+)-Arginine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-21 L-arginine
74-79-3
US $10.00-20.00 / KG 0.5KG >99% 20tons Anhui Rencheng Technology Co., Ltd
2021-10-21 L(+)-Arginine
74-79-3
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-09-29 L(+)-Arginine
74-79-3
US $0.00 / Kg/Drum 1KG 98.5%-101.5%;USP 10 TONS WUHAN FORTUNA CHEMICAL CO., LTD

L(+)-Arginine Spectrum


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