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Tenofovir

Indications and Usage Mechanisms of Action Pharmacokinetics Adverse Effects
Tenofovir
Tenofovir
CAS No.
147127-20-6
Chemical Name:
Tenofovir
Synonyms
Viread;9-Pmpa;GS-1278;GS 1275;(R)-PMPA;Tenofovi;TENOFOVIR;Tenefovir;Apropovir;Aids021800
CBNumber:
CB8218508
Molecular Formula:
C9H14N5O4P
Formula Weight:
287.21
MOL File:
147127-20-6.mol

Tenofovir Properties

Melting point:
276-280°C
alpha 
D +21° (c = 1 in 0.1M HCl)
storage temp. 
Store at -20°C
form 
powder
color 
white to beige
optical activity
[α]/D -20 to -26°, c = 0.5 in 1 M HCl
Water Solubility 
13.4 mg/mL (25 ºC)
Merck 
14,9146
CAS DataBase Reference
147127-20-6(CAS DataBase Reference)

SAFETY

RTECS  SZ6563600

Tenofovir price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical T3006 Tenofovir Hydrate >98.0%(HPLC)(T) 147127-20-6 1g $49 2018-11-22 Buy
TCI Chemical T3006 Tenofovir Hydrate >98.0%(HPLC)(T) 147127-20-6 5g $170 2018-11-22 Buy
Cayman Chemical 13874 Tenofovir ≥98% 147127-20-6 5mg $65 2018-11-13 Buy
Cayman Chemical 13874 Tenofovir ≥98% 147127-20-6 10mg $117 2018-11-13 Buy
Cayman Chemical 13874 Tenofovir ≥98% 147127-20-6 50mg $520 2018-11-13 Buy

Tenofovir Chemical Properties,Uses,Production

Indications and Usage

Tenofovir disoproxil (Viread) is the first nucleotide analogue approved by the American FDA to treat HIV-1 infections. Tenofovir disoproxil is a drug used in the AIDS cocktail treatment method, and research shows that it has the ability to increase monkeys’ immunity to immunodeficiency viruses (similar to the human AIDS virus). Tenofovir disoproxil is used in combination with other reverse transcriptase inhibitors to treat HIV-1 infections and hepatitis B.

Mechanisms of Action

Tenofovir disoproxil is an acyclic nucleoside antivirus drug and has an inhibiting effect on HBV multi-enzyme complexes and HIV reverse transcriptase. Its active content tenofovir phosphonate directly competitively binds to natural deoxyribose substrate to inhibit the virus multi-enzyme complex and inserts itself into the DNA to end the nucleotide chain. Tenofovir disoproxil is barely absorbed by the gastrointestinal duct, so it undergoes esterification and ionization to become tenofovir ester fumarate. Tenofovir is soluble in water and can be quickly absorbed and decomposed into the active substance tenofovir, which then transforms into the active metabolite tenofovir phosphonate. As this drug is not metabolized by the CYP450 enzyme system, it has a very low chance of drug interactions caused by this enzyme.

Pharmacokinetics

Tenofovir disoproxil reaches peak blood concentration 1-2 hours after intake. Tenofovir disoproxil’s bioavailability increases by about 40% when taken with food. The intracellular half-life of tenofovir phosphonate is about 10 hours, so doses can be taken once daily. This drug is mainly filtered through renal glomeruli and excreted through the renal tubule transport system, with 70-80% excreted in its original form through urine.

Adverse Effects

  • Weakness and exhaustion.
  • Mild to moderate gastrointestinal reactions, including diarrhea, stomach pain, nausea, vomiting, bloating, lactic acid poisoning, hepatomegaly and fatty liver, and pancreatitis. These adverse reactions also commonly appear individually or combined when taking nucleoside analogues.
  • Metabolic system hypophosphatemia (1% occurrence rate).
  • Fat accumulation and redistribution, including centripetal obesity, buffalo hump, thin limbs, breast growth, and Cushing syndrome.
  • May cause lactic acid poisoning, hepatomegaly related to steatosis, etc.
  • Effects on nervous system: dizziness and headache.
  • Effects on respiratory system: difficulty breathing.
  • Effects on skin: drug rash.

Chemical Properties

White Crystalline Solid

Uses

Tenofovir is a drug used for the treatment of chronic heptatitis B as well as prevention and treatment of HIV/AIDS. It is a kind of nucleotide analog, acting as the reverse-transcriptase inhibitor (NtRTI). It inhibits the activity of HIV reverse transcriptase through competing with the natural substrate deoxyadenosine 5’-triphosphate, causing the termination of DNA chain. 

Definition

ChEBI: A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxy ethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.

Biological Activity

Selectively inhibits HIV reverse transcriptase (RNA-dependent DNA polymerase). Prevents cytotoxicity in SIV-infected C-8166 cells in vitro (IC 50 = 1.5 μ M). Antiviral agent.

Tenofovir Preparation Products And Raw materials

Raw materials

Preparation Products


Tenofovir Suppliers

Global( 361)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 663 60
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19958 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22058 58
Nanjing Gold Pharmaceutical Technology Co. Ltd.
025-84209270 15906146951
025-84209270 wgp@nanjing-pharmaceutical.com CHINA 117 55
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1531 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20795 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32763 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 14297 60
Shenzhen Nexconn Pharmatechs Ltd
15013857715
admin@nexconn.com CHINA 1135 58

View Lastest Price from Tenofovir manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-26 Tenofovir
147127-20-6
US $100.00 / KG 1KG 99% Customized career henan chemical co
2018-07-25 Tenofovir
147127-20-6
US $200.00 / KG 100G 98% 10KG,20KG career henan chemical co
2018-07-24 Tenofovir
147127-20-6
US $130.00 / G 1G 99% 1kg career henan chemical co

147127-20-6(Tenofovir)Related Search:


  • (R)-(1-(6-aMino-9H-purin-9-yl)propan-2-yloxy)Methylphosphonic acid
  • Tenofovir (PMPA)
  • Tenofovir(Viread)
  • [[(1R)-2(6-AMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]ph
  • Viread
  • 1-(6-AMinopurin-9-yl)propan-2-yloxyMethylphosphonic acid(PMPA)
  • Tenofovir 1-(6-Aminopurin-9-yl)propan-2-yloxymethylphosphonic acid
  • R-PMPA, Tenofovir,
  • Tenofovir, >=98%
  • Tenofovir free base
  • (((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid
  • (R)-(((1-(6-AMINO-9H-PURIN-9-YL)PROPAN-2-YL)OXY)METHYL)PHOSPHONIC
  • 1-(6-aminopurin-9-yl)propan-2-yloxymethylphosphonic acid
  • D,L-TENOFOVIR
  • TENOFOVIR
  • (R)-9-(2-PHOSPHONYLMETHOXYPROPYL)-ADENINE
  • (R)-9-(2-Phosphonomethoxypropyl)Adenine
  • Tenofovir(ForResearchOnly)
  • (R)-PMPA
  • [[(1R)-2(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic Acid
  • GS-1278
  • Tenofovir disoproxil fumarate and intermediates
  • (R)-9-[2-(Phosphonomethoxy)propyl]adenine (PMPA)
  • GS 1275
  • tenofovir (anhydrous)
  • Tenofovirdisoproxil Intermediate PMPA
  • Tenofovi
  • Tenofovir Disoproxil Fumarate impurity P
  • Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]- (9CI)
  • Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, (R)-
  • Tenefovir
  • Tenofovir (R)-9-(2-phosphonomethoxypropyl) adenine
  • 107021-12-5 (Undefined stereochemistry)
  • 206184-49-8 (Hydrate)
  • 9-Pmpa
  • Aids021800
  • Aids-021800
  • Apropovir
  • Tenofovir & Tenofovir Disoproxil Fumarate
  • (R)-[[2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonicacid
  • Tenofovir,TDF,PMPA
  • 147127-20-6
  • Purine
  • ACTIVE PHARMACEUTICAL INGREDIENTS
  • Nucleotides and Nucleosides
  • Bases & Related Reagents
  • Intermediates & Fine Chemicals
  • Nucleotides
  • Pharmaceuticals
  • Phosphorylating and Phosphitylating Agents
  • C9H14N5O4P
  • Inhibitors
  • 14127-20-6
  • 47127-20-6
  • C9H14N5O4PxH2O
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