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L-(-)-루신

L-(-)-루신
L-(-)-루신 구조식 이미지
카스 번호:
61-90-5
한글명:
L-(-)-루신
동의어(한글):
L-(-)-루신;L-루신;L-류신;류신
상품명:
L-Leucine
동의어(영문):
LEU;L-LEU;Leucin;eucine;CH79091;LEUCINE;L-Leu-OH;H-LEU-OH;L-Leudne;1-Leucine
CBNumber:
CB8742186
분자식:
C6H13NO2
포뮬러 무게:
131.17
MOL 파일:
61-90-5.mol

L-(-)-루신 속성

녹는점
>300 °C (lit.)
끓는 점
122-134 °C(Press: 2-3 Torr)
알파
15.4 º (c=4, 6N HCl)
밀도
1,293 g/cm3
증기압
<1 hPa (20 °C)
FEMA
3297 | L-LEUCINE
굴절률
1.4630 (estimate)
인화점
145-148°C
저장 조건
2-8°C
용해도
1 M HCl: 50 mg/mL
물리적 상태
powder
산도 계수 (pKa)
2.328(at 25℃)
색상
White to Off-white
수소이온지수(pH)
5.5-6.5 (20g/l, H2O, 20℃)
optical activity
[α]20/D +15.5°, c = 2 in 6 M HCl
수용성
22.4 g/L (20 C)
최대 파장(λmax)
λ: 260 nm Amax: 0.05
λ: 280 nm Amax: 0.05
JECFA Number
1423
승화점
145-148 ºC
Merck
14,5451
BRN
1721722
안정성
Stability Moisture and light sensitive. Incompatible with strong oxidising agents.
CAS 데이터베이스
61-90-5(CAS DataBase Reference)
NIST
Leucine(61-90-5)
EPA
L-Leucine (61-90-5)

안전

안전지침서 24/25
WGK 독일 3
RTECS 번호 OH2850000
TSCA Yes
HS 번호 29224995
유해 물질 데이터 61-90-5(Hazardous Substances Data)

L-(-)-루신 MSDS


L-Leu

L-(-)-루신 C화학적 특성, 용도, 생산

개요

Small, white, lustrous plates, or a white, crystalline powder, with a slightly bitter taste. One g dissolves in about 40 mL of water and in about 100 mL of acetic acid. It is sparingly soluble in alcohol, but is soluble in dilute hydrochloric acid and in solutions of alkali hydroxides and carbonates. ι-Leucine may be synthesized by bromination, followed by amination of isocaproic acid; via the acetamidomalonic ester; by isolation from gluten, casein, keratin; from hydantoin.

화학적 성질

L-Leucine is odorless and has a slightly bitter taste. L-Leucine is a branched-chain, essential amino acid that stimulates muscle protein synthesis.

화학적 성질

White crystalline powder

화학적 성질

Leucine occurs as a white or almost off-white crystalline powder or shiny flakes.

출처

Reported found as a constituent in proteins; also present in the free state in the human body

용도

Amino acid.

생산 방법

Leucine is produced microbially by incubating an amino-acidproducing microorganism including but not exclusive to Pseudomonas, Escherichia, Bacillus, or Staphylococcus in the presence of oxygen and a hydrocarbon. The nutrient medium should contain an inhibitory amount of a growth inhibitor that is a chemically similar derivative of leucine (e.g. methylallylglycine, a-hydrozinoisocaproic acid, or b-cyclopentanealanine) to inhibit the growth of the organism except for at least one mutant that is resistant to the inhibitory effect. The resistant mutant is then isolated and grown in the presence of oxygen and the hydrocarbon in the absence of the inhibitor. The mutant cells are then harvested and a nutrient medium is formed that includes a hydrocarbon as the sole source of carbon. Finally, the harvested cells are incubated in the medium in the presence of oxygen.

정의

ChEBI: The L-enantiomer of leucine.

제조 방법

By bromination followed by amination of isocaproic acid; via the acetamidomalonic ester; by isolation from gluten, casein, keratin; from hydantoin.

Pharmaceutical Applications

Leucine is used in pharmaceutical formulations as a flavoring agent. It has been used experimentally as an antiadherent to improve the deagglomeration of disodium cromoglycate micro-particles and other compounds in inhalation preparations; and as a tablet lubricant. Leucine copolymers have been shown to successfully produce stable drug nanocrystals in water.

Safety

Leucine is an essential amino acid and is consumed as part of a normal diet. It is generally regarded as a nontoxic and nonirritant material. It is moderately toxic by the subcutaneous route.
LD50 (rat, IP): 5.379 g/kg

저장

Leucine is sensitive to light and moisture, and should be stored in an airtight container in a cool, dark, dry place.

Purification Methods

Likely impurities are isoleucine, valine, and methionine. Crystallise L-leucine from water by adding 4 volumes of EtOH. It sublimes at 180-188o/0.3mm with 99.1% recovery, and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2075-2094 1961, Kameda et al. J Pharm Soc Jpn 78 763 1958, Beilstein 4 IV 2738.]

비 호환성

Leucine is incompatible with strong oxidizing agents.

Regulatory Status

Included in the FDA Inactive Ingredients Database (IV infusion; oral tablets). Included in nonparenteral medicines licensed in the UK.

L-(-)-루신 준비 용품 및 원자재

원자재

준비 용품


L-(-)-루신 공급 업체

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