4-(Aminomethyl)tetrahydro-2H-pyran
- CAS No.
- 130290-79-8
- Chemical Name:
- 4-(Aminomethyl)tetrahydro-2H-pyran
- Synonyms
- oxan-4-ylmethanamine;ASINEX-REAG BAS 07731534;4-Aminotetrahydro-4H-pyran;4-AMINOMETHYLTETRAHYDROPYRAN;4-AMINOMETYYLTETRAHYDROPYRAN;4-(Aminomethyl)tetrahydro...;4-(Aminomethyl) tetrahydro-2;4-(Aminomethyl)tetrahydropyrane;4-AMinoMethyltetrahydropyran 1GR;4-AMinoMethyltetrahydropyran 5GR
- CBNumber:
- CB9418437
- Molecular Formula:
- C6H13NO
- Molecular Weight:
- 115.17
- MDL Number:
- MFCD02179435
- MOL File:
- 130290-79-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Aminomethyltetrahydropyran >98.0%(GC)(T) | A2550 | 1g | $41 |
| 4-Aminomethyltetrahydropyran >98.0%(GC)(T) | A2550 | 5g | $131 |
| 4-Aminomethyltetrahydropyran | A615885 | 2.5g | $220 |
| 4-Aminomethyltetrahydropyran | J94537 | 1g | $10 |
| 4-Aminomethyltetrahydropyran | A987 | 1g | $14 |
| More product size | |||
| Boiling point | 75 °C |
|---|---|
| Density | 1.02 |
| refractive index | 1.4630-1.4670 |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| form | clear liquid |
| pka | 10.01±0.29(Predicted) |
| color | Colorless to Light yellow |
| InChI | InChI=1S/C6H13NO/c7-5-6-1-3-8-4-2-6/h6H,1-5,7H2 |
| InChIKey | IPBPLHNLRKRLPJ-UHFFFAOYSA-N |
| SMILES | C1OCCC(CN)C1 |
| CAS DataBase Reference | 130290-79-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H227-H314 | |||||||||
| Precautionary statements | P210-P260-P264-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P370+P378-P403+P235-P405-P501 | |||||||||
| Hazard Codes | Xi,C,Xn | |||||||||
| Risk Statements | 34-41-37/38-22 | |||||||||
| Safety Statements | 26-36/37/39-45-39 | |||||||||
| RIDADR | 2735 | |||||||||
| HazardClass | IRRITANT | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 29329990 | |||||||||
| NFPA 704 |
|
4-(Aminomethyl)tetrahydro-2H-pyran price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A2550 | 4-Aminomethyltetrahydropyran >98.0%(GC)(T) | 130290-79-8 | 1g | $41 | 2026-04-30 | Buy |
| TCI Chemical | A2550 | 4-Aminomethyltetrahydropyran >98.0%(GC)(T) | 130290-79-8 | 5g | $131 | 2026-04-30 | Buy |
| TRC | A615885 | 4-Aminomethyltetrahydropyran | 130290-79-8 | 2.5g | $220 | 2021-12-16 | Buy |
| AK Scientific | J94537 | 4-Aminomethyltetrahydropyran | 130290-79-8 | 1g | $10 | 2021-12-16 | Buy |
| AK Scientific | A987 | 4-Aminomethyltetrahydropyran | 130290-79-8 | 1g | $14 | 2021-12-16 | Buy |
4-(Aminomethyl)tetrahydro-2H-pyran Chemical Properties,Uses,Production
Chemical Properties
clear colorless liquid
Uses
4-Aminomethyltetrahydropyran is a reagent that is used in core modification in discovery of CC214-2 which is an orally available , selective inhibitor of mTOR kinase. 4-Aminomethyltetrahydropyran is also used as a reagent in the development of pyrazoloquinolines as PDE10A inhibitor for the treatment of schizophrenia.
Synthesis
4295-99-2
130290-79-8
Example 43 (Synthesis of 4-aminomethyltetrahydropyran): In a 200 mL stainless steel autoclave equipped with a stirring device, a thermometer, and a manometer, 10.0 g (90.0 mmol) of 4-cyanotetrahydropyran, 50.0 g of a 22% (w/w) ammonia-methanol solution, and 2.0 g (17.0 mmol as nickel atoms) of activated Raney nickel ( provided by Nikki Chemical Co., Ltd; nickel sponge N154D). The reaction was stirred under hydrogen atmosphere at 45 to 55 °C and 0.51 to 0.61 MPa pressure for 17 hours. After completion of the reaction, the insoluble material was removed by filtration and the filtrate was washed with 30 mL of methanol. The filtrate and washings were combined, concentrated under reduced pressure and then distilled under reduced pressure at 73-74 °C and 2.67 kPa to give 7.94 g (76.6% isolated yield) of 4-aminomethyltetrahydropyran as a colorless liquid. Its physical properties were as follows: 1H-NMR (DMSO-d6, δ (ppm)): 1.02-1.16 (2H, m), 1.10-1.50 (2H, brs), 1.34-1.45 (1H, m), 1.56-1.61 (2H, m), 2.39 (2H, d, J = 6.3 Hz), 3.20-3.29 (2H, m ), 3.81-3.86 (2H, m); CI-MS (m/e): 116 (M+1), 99. Example 45 (Synthesis of 4-aminomethyltetrahydropyran): in a 200 mL stainless steel autoclave equipped with a stirring device, a thermometer, and a manometer, 10.0 g (90.0 mmol) of 4-cyanotetrahydropyran, 100 mL of a 22% (w/w) ammonia-methanol solution, and 2.0 g (17.0 mmol as nickel atoms) of activated Raney nickel ( provided by Nikki Chemical Co., Ltd; nickel sponge N154D). The reaction was stirred under hydrogen atmosphere at 50 to 60 °C and 0.51 to 0.61 MPa pressure for 5 hours. After completion of the reaction, the insoluble material was removed by filtration and the filtrate was washed with 30 mL of methanol. The filtrate and washings were combined and analyzed by gas chromatography (internal standard method) to confirm the formation of 8.84 g (85.3% reaction yield) of 4-aminomethyltetrahydropyran and no by-product bis(4-tetrahydropyranosylmethyl)amine was detected.
References
[1] Patent: EP1671937, 2006, A1. Location in patent: Page/Page column 16-17
[2] Patent: EP1671937, 2006, A1. Location in patent: Page/Page column 17
[3] Justus Liebigs Annalen der Chemie, 1938, vol. 535, p. 37,45
[4] Patent: US6372778, 2002, B1. Location in patent: Example 80
[5] Patent: US2006/63804, 2006, A1. Location in patent: Page/Page column 13
4-(Aminomethyl)tetrahydro-2H-pyran Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| Jiangsu Qingquan Chemical Co., Ltd. | +86-571-86589381,86589382,86589383 | sales1@qqpharm.com | CHINA | 154 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29818 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2176 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
View Lastest Price from 4-(Aminomethyl)tetrahydro-2H-pyran manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-30 | 4-(Aminomethyl)tetrahydro-2H-pyran
130290-79-8
|
US $0.00 / KG | 1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-12-01 | 4-(Aminomethyl)tetrahydro-2H-pyran
130290-79-8
|
US $0.00 / kg | 1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | |
 |
2025-11-18 | 4-(Aminomethyl)tetrahydro-2H-pyran
130290-79-8
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited |
-
- 4-(Aminomethyl)tetrahydro-2H-pyran
130290-79-8
- US $0.00 / KG
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 4-(Aminomethyl)tetrahydro-2H-pyran
130290-79-8
- US $0.00 / kg
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 4-(Aminomethyl)tetrahydro-2H-pyran
130290-79-8
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
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