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설파메톡시피리다진

설파메톡시피리다진
설파메톡시피리다진 구조식 이미지
카스 번호:
80-35-3
한글명:
설파메톡시피리다진
동의어(한글):
설파메톡시피리다진;3-(4-아미노벤젠설포나미도)-6-메톡시피리다진;3-p-아미노벤젠설포나미도-6-메톡시피리다진;4-아미노-N-(6-메톡시-3-피리다진;6-메톡시-3-피리다지닐설파닐아미드;6-설파닐아미도-3-메톡시피리다진;N1-(6-메톡시-3-피리다지닐)설파닐아미드;설파메톡시 피리다진
상품명:
Sulfamethoxypyridazine
동의어(영문):
SMPZ;Durox;Kinex;Kynex;Vinces;Kineks;Lentac;Longin;Myasul;rp7522
CBNumber:
CB1107025
분자식:
C11H12N4O3S
포뮬러 무게:
280.3
MOL 파일:
80-35-3.mol

설파메톡시피리다진 속성

녹는점
182-183°
끓는 점
564.9±60.0 °C(Predicted)
밀도
1.3936 (rough estimate)
굴절률
1.6200 (estimate)
저장 조건
2-8°C
물리적 상태
Crystalline Powder
산도 계수 (pKa)
6.7(at 25℃)
색상
White to yellow
수용성
579.5mg/L(25 ºC)
Merck
14,8919
BRN
277076
CAS 데이터베이스
80-35-3(CAS DataBase Reference)
NIST
Pyridazine, sulfamethoxy-(80-35-3)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 37/38-41
안전지침서 26-39
WGK 독일 2
RTECS 번호 WP0400000
F 고인화성물질 10
HS 번호 29350090
독성 LD50 orally in mice: 1750 mg/kg, (Seki)
기존화학 물질 KE-01439
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H318 눈에 심한 손상을 일으킴 심한 눈 손상 또는 자극성 물질 구분 1 위험 P280, P305+P351+P338, P310
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

설파메톡시피리다진 MSDS


4-Amino-N-(6-methoxy-3-pyridazinyl)-benzenesulfonamide

설파메톡시피리다진 C화학적 특성, 용도, 생산

화학적 성질

White solid

용도

Antibacterial.

정의

ChEBI: A sulfonamide consisting of pyridazine having a methoxy substituent at the 6-position and a 4-aminobenzenesulfonamido group at the 3-position.

Indications

This drug possesses antibacterial activity with respect to a few cocci and colon bacillus. It is a long-lasting drug. It is used for treating pneumonia, bronchitis, tonsillitis, purulent otitis and meningitis, purulent infections of the urinary tract, dysentery, and others. Synonyms of this drug are sulfapyridazine, sufalex, retasulfin, and many others.

상표명

Amidin;Aseptilex;Asey-sulfa;Bimalong;Biocorn;Bio-cron;Bio-pectodil;Davosin suspension;Deltavagin;Desulfon;Durasul jarabe;Elix;Ensulfa;Eusulfa;Exazole;Farinffnicol;Fercasulf;Hesse-sulfon;Ketiak;Kynex acetyl;Lentosulfa;Linder;Logisul jarabe;Longamid;Longisul;Metamit;Metazina;Metuzina;Minikel;Novosulfin;Pirasulfon;Ralenta;Rotardon;S.d.m.;Septotryl;Smop;Sulamin;Sulfa spirig;Sulfabon;Sulfadazina;Sulfadepot;Sulfadin;Sulfadurazin;Sulfaintensa;Sulfakeyn;Sulfametopyridazin;Sulfamizina;Sulfamyd;Sulfapyrazin;Sulfatar;Sulfocidan;Sulfonamid;Sulforetent;Sulfo-rit;Unisulfa dulcis;Uroplex;Velaten;Volocid;Vtg 44.

World Health Organization (WHO)

Sulfamethoxypyridazine, a sulfonamide anti-infective agent, was introduced in 1957 for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. The sulfonamides are known to cause serious adverse effects such as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Commercial manufacture of the drug has been discontinued by at least one major manufacturer but supplies can still be obtained on special request, particularly for patients with dermatitis herpetiformis in which condition it has been claimed to be beneficial.

Pharmaceutical Applications

3-Sulfanilamido-6-methoxypyridazine. Properties are similar to those of sulfadimethoxine. A rapidly absorbed, long-acting compound (half-life 38 h) with a high degree of protein binding (96%). A 1 g oral dose achieves a peak plasma concentration of around 100 mg/L after 5 h. Its use has been largely discontinued because of frequent adverse effects, but there are reports of benefit in dermatitis herpetiformis. It has been used in combination with trimethoprim.

Chemical Synthesis

Sulfamethoxypyridazine, N1 -(6-methoxy-3-pyridazinyl)sulfanilamide (33.1.43), is synthesized by replacing the chlorine atom in 6-chloro-3-(4-aminobenzenesulfonilamido)pyridazine with a methoxy group in 33.1.42 using sodium methoxide. The initial 6-chloro-3-(4-aminobenzenesulfonylamido)-pyridazine (33.1.42) is in turn synthesized by reacting 4-aminobenzenesulfanilamide with easily accessible 3,6-dichloropyridazine.

설파메톡시피리다진 준비 용품 및 원자재

원자재

준비 용품


설파메톡시피리다진 공급 업체

글로벌( 233)공급 업체
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Capot Chemical Co.,Ltd.
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+86-571-85864795 sales@capotchem.com China 20012 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20898 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5930 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213
+86 15821988213 info@longyupharma.com China 2499 58

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