술파디아진
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술파디아진 속성
- 녹는점
- 253 °C (dec.) (lit.)
- 끓는 점
- 512.6±52.0 °C(Predicted)
- 밀도
- 1.3780 (rough estimate)
- 굴절률
- 1.6440 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- 디메틸설폭사이드에 용해됩니다.
- 산도 계수 (pKa)
- pKa 2.21(H2O t = 25 I = 0.5 (NaCl)) (Uncertain)
- 물리적 상태
- 가루
- 색상
- 하얀색
- 수용성
- 67.13mg/L(25℃)
- Merck
- 14,8903
- BRN
- 6733588
- BCS Class
- 4/3
- CAS 데이터베이스
- 68-35-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 22-36/37/38-42/43-43-42 | ||
안전지침서 | 26-36 | ||
유엔번호(UN No.) | 3249 | ||
WGK 독일 | 3 | ||
RTECS 번호 | WP1925000 | ||
F 고인화성물질 | 10 | ||
TSCA | Yes | ||
위험 등급 | 6.1(b) | ||
포장분류 | III | ||
HS 번호 | 29335990 | ||
독성 | LD50 oral in mouse: 1500mg/kg | ||
기존화학 물질 | KE-01586 |
술파디아진 C화학적 특성, 용도, 생산
화학적 성질
White to slightly yellow crystalline pow용도
It is used in the form of silver salts (sulfadiazine silver) as an external antibacterial agent, primarily for treating burns. It is believed that the presence of the silver ion in the molecule facilitates increased antimicrobial and wound-healing action.정의
ChEBI: A sulfonamide consisting of pyrimidine with a 4-aminobenzenesulfonamido group at the 2-position.Antimicrobial activity
Sulfadiazine is somewhat more active than other sulphonamides.일반 설명
Sulfadiazine’s plasma half-life is 17 hours. It is a white,odorless crystalline powder soluble in water to the extentof 1:8,100 at 37°C and 1:13,000 at 25°C, in human serumto the extent of 1:620 at 37°C, and sparingly soluble in alcoholand acetone. It is readily soluble in dilute mineralacids and bases. Its pKa is 6.3.Pharmaceutical Applications
Sulfadiazine is almost insoluble in water and unstable on exposure to light. It is administered orally or, as the sodium salt, by intravenous injection. It is a component of several multi-ingredient preparations. Its low solubility in urine led to its general replacement by other compounds. The intravenous solution is highly alkaline and should not be given by any other route.Pharmacokinetics
Oral absorption: Very goodCmax 3 g oral: c. 50 mg/L after 3–4 h
Plasma half-life :7–12 h
Volume of distribution: 0.36 L/kg
Plasma protein binding: c. 40%
Absorption and distribution
Adequate blood concentrations are easily achieved and maintained after oral administration. It is well distributed and penetrates in therapeutic concentrations into the CSF, but because of resistance it is no longer the drug of choice in meningitis. It crosses the placenta and enters breast milk to achieve concentrations around 20% of plasma levels.
Metabolism and excretion
Sulfadiazine is subject to acetylation in the liver. The acetyl derivative lacks antibacterial activity and is excreted more slowly (half-life 8–18 h). Parent compound and metabolite are both excreted mainly by glomerular filtration.
Clinical Use
Urinary tract infectionNocardiasis
Chancroid
Toxoplasmosis (in combination with pyrimethamine)
Meningococcal infections
Prophylaxis of rheumatic fever
부작용
In addition to side effects common to the group, sulfadiazine inhibits the metabolism of phenytoin. The risk of crystalluria can be reduced by high fluid intake and alkalization of the urine.Safety Profile
Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. Human systemic effects by ingestion: hematuria, anuria, general anesthesia, gastrointestinal effects. Experimental teratogenic and reproductive effects. When heated to decomposition it emits very toxic fumes of NOx and SOx.술파디아진 준비 용품 및 원자재
원자재
Thiamine chloride
에틸비닐에테르
에틸알코올
N,N-다이메틸폼아마이드
프로파질 알코올
다이에틸아민
탄화칼슘
메틸산 나트륨
삼염화 인
설파구아니딘
4-나이트로벤젠설포닐 염화물
2-Aminopyrimidine
준비 용품
술파디아진 공급 업체
글로벌( 521)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12446 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5872 | 58 |
shandong perfect biotechnology co.ltd | +86-53169958659; +8618596095638 |
sales@sdperfect.com | China | 294 | 58 |
Wuhan Quanjinci New Material Co.,Ltd. | +8615271838296 |
kyra@quanjinci.com | China | 1534 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 |
sarah@tnjone.com | China | 1143 | 58 |
Apeloa production Co.,Limited | +8619933239880 |
admin@apcl.com.cn | China | 853 | 58 |
Henan Suikang Pharmaceutical Co.,Ltd. | +86-18239973690 +86-18239973690 |
sales@suikangpharm.com | China | 311 | 58 |
Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 |
admin@zlchemi.com | China | 3002 | 58 |
Hebei Shengyang Water Conservancy Engineering Co., Ltd. | +8615373025980 |
clara@hbshengyang.com | China | 874 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |