Oxaprozin
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Oxaprozin 속성
- 녹는점
- 154 °C
- 끓는 점
- 435.17°C (rough estimate)
- 밀도
- 1.2278 (rough estimate)
- 굴절률
- 1.5100 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- DMSO에 용해됨
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 4.3(at 25℃)
- 색상
- 메탄올에서 얻은 결정체
- 수용성
- 4mg/L(37℃)
- Merck
- 14,6924
- BCS Class
- 2
- 안정성
- 제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.
- InChIKey
- OFPXSFXSNFPTHF-UHFFFAOYSA-N
- CAS 데이터베이스
- 21256-18-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn,Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 20/21/22-36/37/38 | ||
| 안전지침서 | 24/25-36/37/39-36-26 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | RP6990000 | ||
| 위험 참고 사항 | Irritant | ||
| HS 번호 | 29349990 | ||
| 유해 물질 데이터 | 21256-18-8(Hazardous Substances Data) | ||
| 독성 | TDLo orl-rbt: 39 mg/kg (female 6-18D post):TER IYKEDH 15,250,84 |
| 그림문자(GHS): |
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| 신호 어: | Danger | ||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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Oxaprozin C화학적 특성, 용도, 생산
개요
Oxaprozin is a non-steroidal antiinflammatory agent indicated for use in various forms of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. A long T1/2 allows once/twice daily dosing. Structurally it is somewhat unique, being a 3- substituted, rather than a 2-substituted propionic acid.화학적 성질
White Solid용도
Oxaprozin is an anti-inflammatory drug. Oxaprozin was comparable to Aspirin (A687780).정의
ChEBI: A monocarboxylic acid that is a propionic acid derivative having a 4,5-diphenyl-1,3-oxazol-2-yl substituent at position 3. It is non-steroidal anti-inflammatory drug commonly used to relieve the pain and inflammatory responses associated with osteoarthrit s and rheumatoid arthritis.Indications
Oxaprozin (Daypro) is approved for the treatment of osteoarthritis and rheumatoid arthritis. Its long halflife allows for once daily dosing.The most frequently reported adverse effects of this drug are nausea, vomiting, and dyspepsia.일반 설명
Oxaprozin, 4,5-diphenyl-2-oxazolepropionic acid (Daypro),differs from the other members of this group in being anarylpropionic acid derivative. It shares the same propertiesand side effects of other members in this group. It is indicatedfor the short- and long-term management of OA andRA, administered as a once-daily dose of 600- to 1,200-mgdose because of its long duration of action.Pharmacokinetics
Oxaprozin is well absorbed (100%) following oral administration, but maximum plasma concentrations are not reached until 3 to 5 hours following ingestion. Oxaprozin is an anti-inflammatory agent possessing a rapid onset of action and a prolonged duration of action. In both the carrageenan raw paw edema assay and analgetic tests, it was equipotent with aspirin. Oxaprozin has been associated with the appearance of rash and/or mild photosensitivity. Some patients experience an increased incidence of rash on sun-exposed skin during clinical testing.Safety Profile
Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by subcutaneous route. An experimental teratogen. Experimental reproductive effects. An anti-inflammatory agent. When heated to decomposition it emits toxic fumes of NOx.Oxaprozin 준비 용품 및 원자재
원자재
준비 용품
Oxaprozin 공급 업체
글로벌( 299)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21689 | 55 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49390 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 |
1056@dideu.com | China | 3531 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 |
joe@yuhengpharm.com | CHINA | 21149 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | China | 34572 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 |
eric@witopchemical.com | China | 23556 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 28965 | 58 |