Leuprorelin
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Leuprorelin 속성
- 알파
- D25 -31.7° (c = 1 in 1% acetic acid)
- 밀도
- 1.44±0.1 g/cm3(Predicted)
- 저장 조건
- −20°C
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨), 물(약간 용해됨)
- 산도 계수 (pKa)
- 9.82±0.15(Predicted)
- 수용성
- 1mg/ml로 물에 용해됨
- 안정성
- 흡습성
- InChIKey
- RGLRXNKKBLIBQS-VAZQWRJQNA-N
- CAS 데이터베이스
- 53714-56-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 안전지침서 | 22-24/25 | ||
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| WGK 독일 | 2 | ||
| RTECS 번호 | OH6390000 | ||
| 유해 물질 데이터 | 53714-56-0(Hazardous Substances Data) |
| 그림문자(GHS): |
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| 신호 어: | Danger | ||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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Leuprorelin C화학적 특성, 용도, 생산
화학적 성질
Hygroscopic, white or almost white powder.용도
Gonadotropin releasing hormone (gonadorelin) analogue; treatment of prostate cancer.정의
ChEBI: An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-leucyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. Leuprorelin is a synthetic nonapeptide analogue of gonadotropin-releasi g hormone, and is used as a subcutaneous hydrogel implant (particularly as the acetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.Indications
Leuprolide is a potent LH-RH agonist for the first several days to a few weeks after initiation of therapy, and therefore, it initially stimulates testicular and ovarian steroidogenesis. Because of this initial stimulation of testosterone production, it is recommended that patients with prostatic cancer be treated concurrently with leuprolide and the antiandrogen flutamide (discussed earlier). Leuprolide is generally well tolerated, with hot flashes being the most common side effect.Synthesis
The synthesis process of Leuprorelin includes the following steps:(1) Fmoc-Pro-HMPB-AM resin is obtained from Fmoc-Pro-OH and HMPB-AM resin with a substitution degree of 0.2mmol/g～1.2mmol/g as starting materials;
(2) The Fmoc-Pro-HMPB-AM resin was coupled one by one by Fmoc/tBu solid phase method to connect amino acids with protective groups in sequence, and the side chain fully protected leuprolide precursor peptide-HMPB-AM was synthesized Resin;
(3) Cut the side chain fully protected leuprolide precursor peptide-HMPB-AM resin to obtain the side chain fully protected leuprolide precursor peptide;
(4) Fully protected side chain leuprolide precursor peptide undergoes ethylamination to obtain side chain fully protected leuprolide;
(5) Leuprolide is fully protected on the side chain by removing the side chain protecting group to obtain the crude leuprolide peptide;
(6) The crude leuprorelin peptide is separated and purified by a high-pressure liquid phase column and lyophilized to obtain the leuprolide refined peptide.
Leuprorelin 준비 용품 및 원자재
원자재
염화벤질
클로로탄산 페닐에스테르
N-[(tert-Butoxy)carbonyl]-D-tryptophan
Boc-D-Tyr-OH
아니졸
tert-부틸알코올
파라-톨루엔설폰일 염화물
L-(-) 히스티딘
벤젠술포닐클로라이드
DL-세린
TERT-BUTYL FORMATE
L-(+)-아르기닌
N-CARBOBENZOXY-DL-LEUCINE
hydrogen fluoride
BOC-TYR(2,6-DI-CL-BZL)-OH
BOC-HIS(DNP)-OH
Boc-D-Ser(Bzl)-OH
Boc-Arg(Tos)-OH
BOC-D-Leucine monohydrate
N-알파-T-BOC-L-트립토판
BOC-L-Leucine
디사이클로헥실카르보디이미디
준비 용품
Leuprorelin 공급 업체
글로벌( 292)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Apextide Co Ltd | +undefined15700198315 |
senjie.hou@sinopep.com | China | 71 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
| Alpha Biopharmaceuticals Co., Ltd | +86-411-39042497 +8613921981412 |
sales@alphabiopharm.com | China | 886 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
| Rixing Chemical CO.,LTD | +86-13237129059 -13237129059 |
sales@rixingchemi.com | CHINA | 229 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| SUZHOU TIANMA PHARMA GROUP TIANJI BIO-PHARMACEUTICAL CO., LTD. | 68322275 |
renmin@tianmapharma.com | CHINA | 19 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10248 | 58 |
Leuprorelin 관련 검색:
Taspoglutide
Lixisenatide
Triptorelin
Leuprorelin Acetate
Angiotensin acetate
Sermorelin
Octreotide acetate
Oxytocin
Teriparatide acetate
Pramlintide acetate
Teriparatideacetate
ARG-LYS-GLU-VAL-TYR ACETATE SALT
Desmopressin
Secretin Acetate
Triptorelin acetate
Nafarelin Acetate
Ganirelix
Eptifibatide Acetate