Nucleotides and their analogs

The nucleotide is composed by bases, pentose and phosphoric acid, which is the basic unit of biological macromolecules of nucleic acids. Depending on the difference of pentose in nucleotides, they can be divided into ribonucleotides and deoxyribonucleotides, thus constituting two kinds of nucleic acid: ribonucleic acid (RNA) and deoxyribonucleic acid (DNA). The bases composing nucleotide have two types of pyrimidine and purine. Pyrimidine is a 6 ring heterocyclic compound containiong 2 nitrogen atoms, and the common pyrimidine bases in nucleotide include cytosine nucleotides(C), uracil(V)and thymine(T). Purine is a heterocyclic compound containing four nitrogen. Adenine(A) and guanine(G) are the major purine nucleotide base composed nucleotide. Nucleotide is formed by the esterification of sugar hydroxyl groups in nucleoside with phosphated acid after the formation of nucleoside via the condensation of ribose or deoxyribose with bases. The free 5 'nucleotide present in organisms is formed by the esterification of hydroxyl groups of the C5 with pentose phosphate.

Nucleotide is a colorless crystalline powder, which is soluble in water and insoluble in organic solvents. And its solution have optically active, and has a strong UV absorption at 260nm. It is an amphoteric electrolyte, which have different dissociation situations at different pH. These nature has great practical value in the preparation, analysis and measurement of nucleotide.

The application of nucleotide substances is very broad, such as ATP, GTP, 5'- nucleotides, etc. can be used as a supplementary drug; 5'-fluorouracil nucleotide analogs have the anti-cancer effect; poly-cytidine acid is the inducer of interferon and has antiviral activity; in the food industry , inosinic acid and guanylic acid are the co-fresheners of aginomoto, which can greatly increase the flavor of aginomoto; in biological research, nucleotide materials are also the essential reagents.

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Structure Chemical Name CAS MF
ADP ADP 58-64-0 C10H15N5O10P2
Thymidine Thymidine 50-89-5 C10H14N2O5
5-Chlorouracil 5-Chlorouracil 1820-81-1 C4H3ClN2O2
Guanosine 5'-monophosphate disodium salt Guanosine 5'-monophosphate disodium salt 5550-12-9 C10H15N5NaO8P
Mesitylene-2-sulfonyl chloride Mesitylene-2-sulfonyl chloride 773-64-8 C9H11ClO2S
Adenine Sulfate Adenine Sulfate 321-30-2 C10H12N10O4S
6-Mercaptopurine monohydrate 6-Mercaptopurine monohydrate 6112-76-1 C5H6N4OS
6-Chloropurine ribonucleoside 6-Chloropurine ribonucleoside 2004-06-0 C10H11ClN4O4
Cytidine Cytidine 65-46-3 C9H13N3O5
5-Fluorouracil 5-Fluorouracil 51-21-8 C4H3FN2O2
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine 3680-69-1 C6H4ClN3
2-Fluoroadenine 2-Fluoroadenine 700-49-2 C5H4FN5
2,6-Dihydroxypurine 2,6-Dihydroxypurine 69-89-6 C5H4N4O2
Adenosine-5'-diphosphate disodium salt Adenosine-5'-diphosphate disodium salt 16178-48-6 C10H15N5O10P2.2Na
Benzoic anhydride Benzoic anhydride 93-97-0 C14H10O3
5-Nitrouracil 5-Nitrouracil 611-08-5 C4H3N3O4
2,6-Diaminopurine 2,6-Diaminopurine 1904-98-9 C5H6N6
2,6-Dichloropurine 2,6-Dichloropurine 5451-40-1 C5H2Cl2N4
5-CARBETHOXYURACIL 5-CARBETHOXYURACIL 28485-17-8 C7H8N2O4
6-Chloropurine 6-Chloropurine 87-42-3 C5H3ClN4
6-(Methylthio)purine 6-(Methylthio)purine 50-66-8 C6H6N4S
DIBENZYL DIISOPROPYLPHOSPHORAMIDITE DIBENZYL DIISOPROPYLPHOSPHORAMIDITE 108549-23-1 C20H28NO2P
ADENOSINE-5'-MONOPHOSPHATE DISODIUM SALT ADENOSINE-5'-MONOPHOSPHATE DISODIUM SALT 149022-20-8 C10H17N5NaO8P
8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione 666816-98-4 C10H9BrN4O2
5-Nitroso-2,4,6-triaminopyrimidine 5-Nitroso-2,4,6-triaminopyrimidine 1006-23-1 C4H6N6O
1,2,4-Triazole 1,2,4-Triazole 288-88-0 C2H3N3
4,6-Dihydroxy-2-methylpyrimidine 4,6-Dihydroxy-2-methylpyrimidine 40497-30-1 C5H6N2O2
Cytidine 5’-monophosphate Cytidine 5’-monophosphate 63-37-6 C9H14N3O8P
Guanosine Guanosine 118-00-3 C10H13N5O5
5-Ethyluracil 5-Ethyluracil 4212-49-1 C6H8N2O2
2'-Deoxyguanosine monohydrate 2'-Deoxyguanosine monohydrate 961-07-9 C10H13N5O4
1,2,3-1H-Triazole 1,2,3-1H-Triazole 288-36-8 C2H3N3
4-Amino-3-hydrazino-1,2,4-triazol-5-thiol 4-Amino-3-hydrazino-1,2,4-triazol-5-thiol 1750-12-5 C2H6N6S
2,4-Dihydroxypyrimidine-5-carboxylic acid 2,4-Dihydroxypyrimidine-5-carboxylic acid 23945-44-0 C5H4N2O4
2'-Deoxyuridine 2'-Deoxyuridine 951-78-0 C9H12N2O5
N4-Benzoylcytosine N4-Benzoylcytosine 26661-13-2 C11H9N3O2
Adenosine5'-(tetrahydrogen triphosphate), disodiuM salt, trihydrate (9CI) Adenosine5'-(tetrahydrogen triphosphate), disodiuM salt, trihydrate (9CI) 51963-61-2 C10H19N5NaO14P3
Tetrazole Tetrazole 288-94-8 CH2N4
CYTIDINE 5'-DIPHOSPHOCHOLINE CYTIDINE 5'-DIPHOSPHOCHOLINE 987-78-0 C14H26N4O11P2
5-Azacytidine 5-Azacytidine 320-67-2 C8H12N4O5
N4-Acetylcytosine N4-Acetylcytosine 14631-20-0 C6H7N3O2
5-Iodo-2,4-dimethoxypyrimidine 5-Iodo-2,4-dimethoxypyrimidine 52522-99-3 C6H7IN2O2
CTP CTP 65-47-4 C9H16N3O14P3
2,6-Dihydroxy-3-methylpurine 2,6-Dihydroxy-3-methylpurine 1076-22-8 C6H6N4O2
Guanine hydrochloride Guanine hydrochloride 635-39-2 C5H6ClN5O
2'-Deoxyinosine 2'-Deoxyinosine 890-38-0 C10H12N4O4
Purine Purine 120-73-0 C5H4N4
N-Benzoylaminopurine N-Benzoylaminopurine 4005-49-6 C12H9N5O
Adenosine 5'-monophosphate disodium salt Adenosine 5'-monophosphate disodium salt 4578-31-8 C10H12N5Na2O7P
6-Hydrazinopurine 6-Hydrazinopurine 5404-86-4 C5H6N6
Isocytosine Isocytosine 108-53-2 C4H5N3O
5-Amino-4,6-dichloro-2-methylpyrimidine 5-Amino-4,6-dichloro-2-methylpyrimidine 39906-04-2 C5H5Cl2N3
URIC ACID URIC ACID 69-93-2 C5H4N4O3
5'-O-Dimethoxytrityl-deoxythymidine 5'-O-Dimethoxytrityl-deoxythymidine 40615-39-2 C31H32N2O7
6-Methoxyguanine 6-Methoxyguanine 20535-83-5 C6H7N5O
5-IODO-1,3-DIMETHYLURACIL 5-IODO-1,3-DIMETHYLURACIL 40738-83-8 C6H7IN2O2
4,5,6-TRIAMINOPYRIMIDINE SULFATE 4,5,6-TRIAMINOPYRIMIDINE SULFATE 6640-23-9 C4H11N5O5S
6-Dimethylaminopurine 6-Dimethylaminopurine 938-55-6 C7H9N5
DIHYDROTHYMINE DIHYDROTHYMINE 696-04-8 C5H8N2O2
1,3-DIMETHYLURIC ACID 1,3-DIMETHYLURIC ACID 944-73-0 C7H8N4O3
6-Methylpurine 6-Methylpurine 2004-03-7 C6H6N4
6-Amino-3,7-dihydro-2H-purin-2-one 6-Amino-3,7-dihydro-2H-purin-2-one 3373-53-3 C5H5N5O
5,6-DIHYDROURACIL 5,6-DIHYDROURACIL 504-07-4 C4H6N2O2
2-Aminopurine 2-Aminopurine 452-06-2 C5H5N5
Nucleoside Nucleoside
DITHIOURACIL DITHIOURACIL 2001-93-6 C4H4N2S2
1H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine 1H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine 1123-54-2 C4H4N6
6-AZATHYMINE 6-AZATHYMINE 932-53-6 C4H5N3O2
1-(4-NITROBENZENESULFONYL)-1H-1,2,4-TRIAZOLE 1-(4-NITROBENZENESULFONYL)-1H-1,2,4-TRIAZOLE 57777-84-1 C8H6N4O4S
5-N-PROPYLURACIL 5-N-PROPYLURACIL 19030-75-2 C7H10N2O2
6-Chloroguanine 6-Chloroguanine 10310-21-1 C5H4ClN5
5-METHYLCYTOSINE HYDROCHLORIDE 5-METHYLCYTOSINE HYDROCHLORIDE 58366-64-6 C5H8ClN3O
Flavin adenine dinucleotide disodium salt Flavin adenine dinucleotide disodium salt 84366-81-4 C27H34N9NaO15P2
Ethyl tetrazole-5-carboxylate Ethyl tetrazole-5-carboxylate 55408-10-1 C4H6N4O2
5-METHYLCYTOSINE 5-METHYLCYTOSINE 554-01-8 C5H7N3O
6-Methylthioguanine 6-Methylthioguanine 1198-47-6 C6H7N5S
DI-TERT-BUTYLDICHLOROSILANE DI-TERT-BUTYLDICHLOROSILANE 18395-90-9 C8H18Cl2Si
8-AZAGUANINE 8-AZAGUANINE 134-58-7 C4H4N6O
6-THIOXANTHINE 6-THIOXANTHINE 2002-59-7 C5H4N4OS
3-ISOBUTYL-1-METHYLXANTHINE 3-ISOBUTYL-1-METHYLXANTHINE 28822-58-4 C10H14N4O2
Potassium orotate Potassium orotate 24598-73-0 C5H3KN2O4
2,4,5,6-TETRAMETHYLBENZENEDISULFONYL DICHLORIDE 2,4,5,6-TETRAMETHYLBENZENEDISULFONYL DICHLORIDE 97997-76-7 C10H12Cl2O4S2
Nicotinamide-N-oxide Nicotinamide-N-oxide 1986-81-8 C6H6N2O2
GUANINE SULFATE GUANINE SULFATE 10333-92-3 C10H12N10O6S
Diethyl chlorothiophosphate Diethyl chlorothiophosphate 2524-04-1 C4H10ClO2PS
8-Bromoguanosine 8-Bromoguanosine 4016-63-1 C10H12BrN5O5
6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione 6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione 6972-27-6 C6H7ClN2O2
METHYL PHOSPHORODICHLORIDITE METHYL PHOSPHORODICHLORIDITE 3279-26-3 CH3Cl2OP
N-MESITYLENESULFONYLIMIDAZOLE N-MESITYLENESULFONYLIMIDAZOLE 50257-39-1 C12H14N2O2S
1,3-BENZODITHIOLYLIUM TETRAFLUOROBORATE 1,3-BENZODITHIOLYLIUM TETRAFLUOROBORATE 57842-27-0 C7H5BF4S2
5-IODOCYTOSINE 5-IODOCYTOSINE 1122-44-7 C4H4IN3O
6-AZA-2-THIOTHYMINE 6-AZA-2-THIOTHYMINE 615-76-9 C4H5N3OS
Thymidine-5'-monophosphate disodium salt Thymidine-5'-monophosphate disodium salt 33430-62-5 C10H13N2Na2O8P
3-METHYLADENINE 3-METHYLADENINE 5142-23-4 C6H7N5
2-Amino-6-iodopurine 2-Amino-6-iodopurine 19690-23-4 C5H4IN5
RIBOFLAVIN-5'-PHOSPHATE SODIUM SALT DIHYDRATE RIBOFLAVIN-5'-PHOSPHATE SODIUM SALT DIHYDRATE 6184-17-4 C17H24N4NaO10P
1-(2,4,6-Triisopropylphenylsulfonyl)imidazole 1-(2,4,6-Triisopropylphenylsulfonyl)imidazole 50257-40-4 C18H26N2O2S
Adenine hydrochloride hemihydrate Adenine hydrochloride hemihydrate 6055-72-7 C5H8ClN5O
5-ETHYL-2-THIOURACIL 5-ETHYL-2-THIOURACIL 34171-37-4 C6H8N2OS
6-Methoxypurine 6-Methoxypurine 1074-89-1 C6H6N4O
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