ChemicalBook CAS DataBase List 2,4-Diisopropyl-5-methylphenol

2,4-Diisopropyl-5-methylphenol synthesis

10synthesis methods

Product Name:2,4-Diisopropyl-5-methylphenol
CAS Number:40625-96-5
Molecular formula:C13H20O
Molecular Weight:192.3

108-39-4
501 suppliers
$13.00/25g

67-63-0 Synthesis

67-63-0
1610 suppliers
$17.00/25ML

89-83-8 Synthesis

89-83-8
732 suppliers
$5.00/10g

40625-96-5
5 suppliers
inquiry

Yield:89-83-8 32% ，40625-96-5 48%

Reaction Conditions:

with carbon tetrabromide at 220 - 250; for 6 h;Sealed tube;

Steps:

General procedure of the synthesis

General procedure: The reactions were performed in a glass ampoule (V = 12 mL) put in a stainless steel microautoclave (V = 17 mL). The ampoule was charged with 5 wt % of the catalyst (with respect to ArOH), 100 mmol of phenol or cresol, 200 mmol of the alcohol, and 10 mmol of CBr₄ (CHBr₃, CHCl₃, CCl₄) under argon. The sealed ampoule was put in the autoclave which was closed and heated at 150-250° during 6-8 h at stirring. After cooling the reactor to ~20°, the ampoule was opened, the reaction mass was neutralized with 10% aqueous solution of Na₂CO₃, and the organic layer was extracted with methylene chloride and filtered. After removal of the solvent, the residue was separated via chromatography (eluting with a 3 : 1 n-hexane-benzene mixture on a column with l = 21 cm, d = 1.2 cm).

References:

Bayguzina;Makhiyanova;Khazipova;Khusnutdinov [Russian Journal of General Chemistry,2019,vol. 89,# 8,p. 1554 - 1559][Zh. Obshch. Khim.,2019,vol. 89,# 8,p. 1557 - 1563,6]

64-17-5 Synthesis