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Fluoruracil Produkt Beschreibung

CAS-Nr.51-21-8
Bezeichnung:Fluoruracil
Englisch Name:5-Fluorouracil
Synonyma:Fluoruracil
FU;Ulup;5-FU;Fluri;Fluril;Arumel;Efudex;Efudix;Efurix;U-8953
CBNumber:CB8162744
Summenformel:C4H3FN2O2
Molgewicht:130.08
MOL-Datei:51-21-8.mol
Fluoruracil physikalisch-chemischer Eigenschaften
Schmelzpunkt:: 282-286 °C (dec.)(lit.)
Siedepunkt:: 190-200°C/0.1mmHg
Dichte: 1.4593 (estimate)
storage temp. : Store at 0-5
Löslichkeit: H2O: 10 mg/mL, clear
Aggregatzustand: powder
pka: pKa 8.0±0.1 (H2O) (Uncertain);3.0±0.1(H2O) (Uncertain)
Farbe: white
PH: 4.3-5.3 (10g/l, H2O, 20℃)
Wasserlöslichkeit: 12.2 g/L 20 ºC
Sensitive : Air Sensitive
Merck : 14,4181
BRN : 127172
Stabilität:: Stable. Light sensitive. Combustible. Incompatible with strong oxidizing agents, strong bases.
InChIKey: GHASVSINZRGABV-UHFFFAOYSA-N
CAS Datenbank: 51-21-8(CAS DataBase Reference)
NIST chemische Informationen: 2,4-Pyrimidinedione, 5-fluoro-(51-21-8)
EPA chemische Informationen: 2,4(1H,3H)-Pyrimidinedione, 5-fluoro-(51-21-8)
Sicherheit
Kennzeichnung gefährlicher: Xn,T,C,Xi
R-Sätze:: 22-20/21/22-52-25
S-Sätze:: 36-36/37-36/37/39-22-45-26
RIDADR : UN 2811 6.1/PG 3
WGK Germany : 3
RTECS-Nr.: YR0350000
F : 10-23
Hazard Note : Irritant/Highly Toxic
TSCA : T
HazardClass : 6.1
PackingGroup : III
HS Code : 29335995
Giftige Stoffe Daten: 51-21-8(Hazardous Substances Data)
Toxizität: LD50 orally in Rabbit: 230 mg/kg

Fluoruracil Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
White or almost white, crystalline powder
Chemische Eigenschaften
Fluorouracil is a white crystalline solid. Practically odorless.
Verwenden
antineoplastic, pyrimidine antimetabolite
Verwenden
5-Fluoro Uracil is an active metabolite of Doxifluridine (D556750).
Verwenden
A potent antineoplastic agent in clinical use. Also an inhibitor of DNA synthesis
Trademarks
Adrucil (Pharmacia & Upjohn); Adrucil (Sicor); Carac (Sanofi Aventis); Efudex (Valeant); Fluoroplex (Allergan).
Allgemeine Beschreibung
White to nearly white crystalline powder; practically odorless. Used as an anti neoplastic drug, chemosterilant for insects.
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
5-Fluorouracil may be sensitive to prolonged exposure to light. Solutions discolor on storage. 5-Fluorouracil can react with oxidizing agents and strong bases. Incompatible with methotrexate sodium.
Hazard
Questionable carcinogen.
Health Hazard
Minimum toxic dose in humans is approximately 450 mg/kg (total dose) over 30 days for the ingested drug. Intravenous minimum toxic dose in humans is a total dose of 6 mg/kg over three days. Depression of white blood cells occurred after intravenous administrative of a total dose of 480 mg/kg over 32 days. Occasional neuropathy and cardiac toxicity have been reported. Do not use during pregnancy. Patients with impaired hepatic or renal function, with a history of high-dose pelvic irradiation or previous use of alkylating agents should be treated with extreme caution. Patients with nutritional deficiencies and protein depletion have a reduced tolerance to 5-Fluorouracil.
Brandgefahr
Emits very toxic fumes of flourides and nitrogen oxides when heated to decomposition. Avoid decomposing heat.
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S22:Staub nicht einatmen.
Biologische Aktivität
Anticancer agent. Metabolized to form fluorodeoxyuridine monophosphate (FdUMP), fluorodeoxyuridine triphosphate (FdUTP) and fluorouridine (FUTP). FdUMP inhibits thymidylate reductase causing a reduction in dTMP synthesis. FUTP and FdUTP are misincorporated into RNA and DNA respectively.
Sicherheitsprofil
Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by parented and rectal routes. Experimental teratogenic and reproductive effects. Human systemic effects: EKG changes, bone marrow changes, cardiac, pulmonary, and gastrointestinal effects. Human mutation data reported. A human skin irritant. Questionable carcinogen. When heated to decomposition it emits very toxic fumes of Fand NOx.
mögliche Exposition
This material is used as an antineo plastic drug for cancer treatment and as a chemosterilant for insects.
Erste Hilfe
If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, includ ing resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medi cal attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. Keep victim quiet and maintain normal body temperature.
Versand/Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Inkompatibilitäten
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo sions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, methotrexrate sodium, sources of heat.
Fluoruracil Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Ethylfluoracetat Ameisensäure-ethylester Natriummethanolat
Downstream Produkte
5-Fluor-1-(tetrahydro-2-furyl)uracil 5-Fluor-2'-desoxyuridin Flucytosin
Fluoruracil Anbieter Lieferant Produzent Hersteller Vertrieb Händler.      Global( 478)Lieferanten     
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
China Synchem Technology Co.,Ltd.
0552-4929304
0552-4928800sales@cnsynchem.com CHINA 45 55
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925Abel@chembj.com CHINA 3218 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22058 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693info@tianfuchem.com CHINA 20795 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733sales@mainchem.com CHINA 32764 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012sales03@shyrchem.com CHINA 663 60
Jiangsu Qingquan Chemical Co., Ltd.
+86-571-86589381/86589382/86589383
lyy@qqpharm.comsales1@qqpharm.com CHINA 137 55
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 956 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20001 58
Alfa Aesar 400-610-6006; 021-67582000
021-67582001/03/05saleschina@alfa-asia.com China 30308 84
 
51-21-8(Fluoruracil)Verwandte Suche:
Sulfamerazin 5-Fluoruridin Rotenon 1-β-D-Arabinofuranosyl-5-fluor-(1H,3H)-pyrimidin-2,4-dion Resmethrin (ISO) alpha-Cyan-3-phenoxybenzyl-3-(2-chlor-3,3,3-trifluorprop-1-enyl)-2,2-dimethylcyclopropan-carboxylat, 1:1 Gemisch der(Z)-(1R,3R), S-ester und(Z)-(1S,3S), R-ester 5-Fluor-1-(tetrahydro-2-furyl)uracil 5-Fluor-2'-desoxyuridin 5-Fluoruracil-4-carbonsure 2-Chloro-5-fluoropyrimidine Fluoruracil pyrimidinedione 5-Methyluracil Fluor Flucytosin 5-Fluoropyrimidine 3,5,5-Trimethyl-2-cyclohex-2-enon 6-Methyluracil
[180]-5-Fluorouracil 2,4(1H,3H)-Pyrimidinedione, 5-fluoro- 2,4-dioxo-5-fluoropyrimidine 3h)-pyrimidinedione,5-fluoro-4(1h 5-faracil 5-Flouracyl Fluoroplex fluoro-uracile fluoro-uracilo fluorouracilum Fluracil Fluracilum Fluri Fluril fluroblastin flurouracil Ftoruracil Kecimeton NSC 19893 nsc19893 1-FLUORO-1H-PYRIMIDINE-2,4-DIONE 2,4-DIHYDROXY-5-FLUOROPYRIMIDINE FLUOROURACIL FU 5-Fluoro-2,4-(1H,3H)-pyrimidindion Fluorouracil ,5-FU FLUOROURACIL USP 5-Flurouracil 5-Fluorouracilgmpusp27 5-FluorouracilGmp 5-Fluorouracil/Fluorouracilum 5-FluoroUracilExtraPure 2,4(1H,3H)-Pyrimidinedione, 5-fluoro- (9CI) 5-Fluorouracil,99% 5-Fluorouracil (technical) Fluoracil 5-FLUOROURACIL(FDA) 5-Fluoropyrimidine-2,4(1H,3H)-dione, 2,4-Dioxo-5-fluoro-1,2,3,4-tetrahydropyrimidine 5-Fluorouracil (2,4-dioxo-5-FluoropyriMidine)(5-FU) 5-Fluorouracil, 97+% Fluorouracil (5-Fluoracil, 5-FU) Dihydroxy-5-fluoropyrimidine 5-Fluorouracil Synonyms Adrucil (Fluorouracil) 5-Fluorouracil Vetec(TM) reagent grade, >=99% 5-Fluorouracil(5-FU) 5- fluorouracil (5- fluorouracil) 5-Fluorouracil, 99%, DNA/RNA synthesis inhibitor Fluorouracil (5-Fluorouracil) 51-21-8 5-FU, 5-Fluorouracil 5-fluor-2,4(1h,3h)-pyrimidindion 5-Fluor-2,4-dihydroxypyrimidin 5-Fluor-2,4-pyrimidindiol 5-Fluoracil 5-fluoropyrimidin-2,4-diol 5-fluoro-uraci 5-Fluoruracil
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