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Carnosine

Carnosine structure

CAS No.: 305-84-0

Chemical Name:: Carnosine

Synonyms: CARNOSINE;N-B-ALANYL-L-HISTIDINE;Carnosin;Dragosine;β-Ala-His;H-β-Ala-His-OH;β-Alanyl-L-histidine;BETA-ALANYL-L-HISTIDINE;N-BETA-ALANYL-L-HISTIDINE;n-2-m

CBNumber:: CB00125962

Molecular Formula:: C9H14N4O3

Molecular Weight:: 226.23

MDL Number:: MFCD00005207

MOL File:: 305-84-0.mol

MSDS File:: SDS

Last updated:2025-12-11 11:21:09

Product description	Number	Pack Size	Price
L-Carnosine ~99%, crystalline	C9625	10mg	$28.3
L-Carnosine ~99%, crystalline	C9625	5g	$143
beta-Alanyl-L-histidine >98.0%(HPLC)(T)	A0222	1g	$19
beta-Alanyl-L-histidine >98.0%(HPLC)(T)	A0222	5g	$55
L-Carnosine	29825	5g	$49
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Carnosine Properties

Melting point	253 °C (dec.) (lit.)
Boiling point	367.84°C (rough estimate)
alpha	20.9 º (c=1.5, H2O)
Density	1.2673 (rough estimate)
vapor pressure	0Pa at 25℃
refractive index	21 ° (C=2, H2O)
storage temp.	-20°C
solubility	DMSO (Very Slightly), Water (Slightly)
form	crystalline
pka	2.62(at 25℃)
color	White
Odor	at 100.00?%. odorless
optical activity	+24.120
Water Solubility	almost transparency
Merck	14,1850
BRN	87671
Stability	Stable, but may be heat sensitive - store cold. Incompatible with strong oxidizing agents.
InChIKey	CQOVPNPJLQNMDC-ZETCQYMHSA-N
LogP	-3.8 at 22℃
CAS DataBase Reference	305-84-0(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	8HO6PVN24W
NCI Drug Dictionary	carnosine
EPA Substance Registry System	L-Histidine, .beta.-alanyl- (305-84-0)
UNSPSC Code	12352209
NACRES	NA.26

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38
Safety Statements	24/25-36-26
WGK Germany	2
RTECS	MS3080000
F	3-10
TSCA	Yes
HS Code	29332900
Toxicity	LD50 oral in mouse: > 14930mg/kg

Carnosine price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C9625	L-Carnosine ~99%, crystalline	305-84-0	10mg	$28.3	2025-07-31	Buy
Sigma-Aldrich	C9625	L-Carnosine ~99%, crystalline	305-84-0	5g	$143	2025-07-31	Buy
TCI Chemical	A0222	beta-Alanyl-L-histidine >98.0%(HPLC)(T)	305-84-0	1g	$19	2025-07-31	Buy
TCI Chemical	A0222	beta-Alanyl-L-histidine >98.0%(HPLC)(T)	305-84-0	5g	$55	2025-07-31	Buy
Cayman Chemical	29825	L-Carnosine	305-84-0	5g	$49	2024-03-01	Buy

Product number	Packaging	Price	Buy
C9625	10mg	$28.3	Buy
C9625	5g	$143	Buy
A0222	1g	$19	Buy
A0222	5g	$55	Buy
29825	5g	$49	Buy

Carnosine Chemical Properties,Uses,Production

Biological Functions

Although it is well known that carnosine plays an important role in exercise performance and skeletal muscle homeostasis, its definitive role is still not established. Carnosine functions as a high-energy phosphate system comparable to the creatine/phosphocreatine system. In their experiments, Severin et al. demonstrated that carnosine plays a role in contractile function of skeletal muscle. In nerve-muscle preparation of frogs, it has been shown that the offset of the fatigue could occur during rhythmic nerve-stimulated muscle contractions if 10 mM of carnosine was added to the surrounding medium. This is also true for anserine[1].

General Description

Carnosine is a dipeptide synthesized in the body from β-alanine and L-histidine. It is found in high concentrations in the brain, muscle, and gastrointestinal tissues of humans and is present in all vertebrates. Carnosine has a number of beneficial antioxidant properties. For example, carnosine scavenges reactive oxygen species (ROS) as well as alpha-beta unsaturated aldehydes created by peroxidation of fatty acid cell membranes during oxidative stress. Carnosine can oppose glycation, and it can chelate divalent metal ions. Carnosine alleviates diabetic nephropathy by protecting podocyte and mesangial cells, and can slow down aging[1].

Biological Activity

Evidence from animal studies showed that carnosine supplementation may reduce body weight, blood pressure level, serum lipid levels, and atherosclerotic plaque instability, thus inhibiting the development and/or progression of hypertension and atherosclerosis. However, well controlled human clinical trials investigating the role of carnosine in preserving and improving cardiovascular health are still scarce. A randomized placebo-controlled trial reported that 4-month treatment with a dietary supplement containing cinnamon, chromium, and carnosine (1.2 g/day) decreased fasting blood glucose and increased fat-free mass in overweight or obese pre-diabetic subjects. Furthermore, other randomized controlled trial demonstrated that L-carnosine (500 mg/d), added to conventional therapy for six months, significantly improved cardiopulmonary exercise test and the 6-min walking test, but not left-ventricular ejection fraction in patients with chronic heart failure[1].

References

[1] Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation. Antioxidants (Basel). 2021 Jul; 10(7): 1037. DOI: 10.3390/antiox10071037

Carnosine synthesis

Synthesis of Carnosine from tert-Butyl cyanoacetate and D-Histidine

Carnosine Preparation Products And Raw materials

Raw materials

D-Histidine tert-Butyl cyanoacetate

Preparation Products

Carnosine Suppliers

Global( 933)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Enviko Biotechnologyg Co.,Ltd	+86-13918629532 +86-13918629532	info@envikobio.com	China	239	58
Xi'an Kono chem co., Ltd.,	029-86107037 13289246953	info@konochemical.com	China	1169	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49934	58
Xinxiang Aurora Biotechnology Co.,Ltd.	+86-0086-0373-3088722 +8618637352520	info@aurora-biotech.com	China	112	58
BJV BIOTECH LTD	+86-0755-23089946 +8619006605307	bjvbiotech@163.com	China	67	58
WeiTai BioPharmaceutical Co.,Ltd(Hangzhou?)	+86-86-057182358004 +8613588879771	info@weitai-pharmaceutical.com	China	61	58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd.	+86-519-85525359 +86-15995072465	sales@xuanmingchem.com	China	912	58
Sinoway Industrial co., ltd.	+86-0592-5800732 +86-13806035118	xie@china-sinoway.com	China	1275	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81148696 +86-17392712697	1022@dideu.com	China	3994	58
Shanghai Yunao International Trade Co., Ltd	+8617621705551	asdf@shanghaihg.cn	China	264	58

Supplier	Advantage
Shanghai Enviko Biotechnologyg Co.,Ltd	58
Xi'an Kono chem co., Ltd.,	58
GIHI CHEMICALS CO.,LIMITED	58
Xinxiang Aurora Biotechnology Co.,Ltd.	58
BJV BIOTECH LTD	58
WeiTai BioPharmaceutical Co.,Ltd(Hangzhou?)	58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd.	58
Sinoway Industrial co., ltd.	58
Shaanxi Dideu Medichem Co. Ltd	58
Shanghai Yunao International Trade Co., Ltd	58

Medicinal Uses and Mechanism of Action of L-Carnosine
L-Carnosine is a naturally occurring beta peptide compound with a wide range of important physiological functions including an....
Dec 16，2024

L-Carnosine: Food sources, Onset of action and Benefits
L-Carnosine (β-alanyl-l-histidine) was a dipeptide isolated from natural material in 1900.
Jun 4，2024

L‐carnosine eye drops and L-carnosine syrup
L-Carnosine is a dipeptide composed of two amino acids, alanine, and histidine, naturally occurring in vital organs like the h....
Apr 16，2024

Related Qustion

Ask a question

Q:What are the side effects of L-carnosine?jia - Nov 7，2025

A:L-Carnosine is generally considered a safe supplement for short-term use, but it can cause some side effects, which are usually mild. Common side effects mainly involve gastrointestinal discomfort, such as nausea, vomiting, diarrhea, or stomach cramps; taking it with food may help relieve these symptoms. Other less common mild reactions include rash, dry mouth, changes in appetite, and fatigue. However, it's important to note that L-carnosine has the potential to lower blood pressure, so people with low blood pressure or those taking antihypertensive medication should use it with caution to avoid lowering their blood pressure too much. Additionally, it may affect blood sugar levels; people with diabetes should consult their doctor before use and are advised to stop taking it at least two weeks before any scheduled surgery to avoid interfering with blood sugar control during and after the procedure. It is generally not recommended for pregnant or breastfeeding women because its safety has not been fully established. It is best to consult a healthcare professional before starting L-carnosine or any new supplement to ensure it is suitable for your individual health condition.

Q:Can L-Carnosine be used to treat autism spectrum disorders (ASD)?Anonymous - Aug 27，2025

A:Yes. L-Carnosine is a potential therapeutic agent for autism spectrum disorder (ASD) currently in the research phase and not yet in clinical use. L-Carnosine comprises β-alanine and L-histidine. Research indicates it possesses neuroprotective, antioxidant, and anticonvulsant properties, which may benefit affected children with this condition. Furthermore, it has been shown to improve speech comprehension, social skills, and behaviour in children with ASD, while reducing hyperactivity. However, it does not appear to cure ASD.

View Lastest Price from Carnosine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-03-31	CARNOSINE 305-84-0	US $20.00-10.00 / BOX	10BOX	99	20TONS	Shanghai Chinqesen Biotechnology Co., Ltd.
	2022-04-05	Carnosine 305-84-0	US $0.00 / KG	0.01KG	99%	1 tons	Wuhan Godbullraw Chemical Co.,ltd

CARNOSINE
305-84-0
US $20.00-10.00 / BOX
99
Shanghai Chinqesen Biotechnology Co., Ltd.

Carnosine
305-84-0
US $0.00 / KG
99%
Wuhan Godbullraw Chemical Co.,ltd

L-Carnosine Spectrum

L-Carnosine(305-84-0)MS L-Carnosine(305-84-0)¹HNMR L-Carnosine(305-84-0)IR1 L-Carnosine(305-84-0)IR2 L-Carnosine(305-84-0)Raman

305-84-0(Carnosine)Related Search:

β-Alanine L-Alanyl-L-Glutamine EC 2.3.2.2 L-Malic acid L-Tyrosine

L-Aspartic acid Methyl (S)-(-)-lactate L-Valine L-carnitine L-Lysine

L-Glutamine H-LEU-LEU-OH L-Pyroglutamic acid L(+)-Arginine CARNOSINE, L-(P),CARNOSINE, L-(RG)

n-acetyl carnosine,N-ACETYL-L-CARNOSINE,N-Aceyl-L-Carnosine L-ANSERINE NITRATE ZINC CARNOSINE,zinc l-carnosine complex,Zinc L-Carnosine,Zn Carnosine,carnosine, zinc- Carnosine

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L-Histidine,beta-alanyl- L-Carnosine (beta-Alanyl-L-histidine) β-Ala-His-OH L-Carnosine,N-beta-Alanyl-L-histidine H-BETA-ALA-HIS-OH L-IGNOTINE L-BETA-ALANINE HISTIDINE L-CARNOSINE B-ALANYL-L-HISTIDINE BETA-A-H BETA-ALA-L-HIS BETA-ALA-HIS CARNOSINE, L- Beta-Alanyl-L-Hystidine L-CARNOSINE CRYSTALLINE L-Carnosine(H-b-Ala-His-Oh) (2S)-2-(3-aminopropanoylamino)-3-(3H-imidazol-4-yl)propanoic acid L-HISTIDINE,N-BETA-ALANYL H-SS-ALA-HIS-OH (L-CARNOSINE) L-B-ALANINE HISTIDINE L-CARNITINEOROTIC H-SS-ALA-HIS-OH H-b-Ala-His-OH Karnozin β-Ala-L-His-OH L-Carnosine,98% L-Carnosine L-Ignotine H-Beta-Ala-His-OH(L-Carnosine) beta-Alanyl-histidine ignotine karnozzn n-2-m Nalpha-(beta-alanyl)-L-histidine n-beta-alanyl-l-histidin L-Carnosine Vetec(TM) reagent grade, 98% Polaprezinc Impurity 6 (2S)-2-(3-Aminopropanamido)-3-(4H-imidazol-4-yl)propanoicacid Carnosin、L-Carnosine L-Carnosine / Carnosine L-Carnosine Reference Material beta L β-Alanyl-L-histidine> 2,5-diamino-3-(1H-imidazol-5-yl)-4-oxohexanoic acid L-Histidine, β-alanyl- L-Carnosine USP/EP/BP carnosine/l-carnosine (2S)-2-(3-aminopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid N-B-ALANYL-L-HISTIDINE BETA-ALANYL-L-HISTIDINE CARNOSINE N-BETA-ALANYL-L-HISTIDINE Carnosin Dragosine H-β-Ala-His-OH β-Ala-His β-Alanyl-L-histidine N-β-alanyl-L-histidine B-Ala-His