Pheniramine
- CAS No.
- 86-21-5
- Chemical Name:
- Pheniramine
- Synonyms
- AVIL;Metron;Pyriton;Trimeton;Tripoton;Feniramine;NCI-C60695;PHENIRAMINE;Propheniramine;PHENIRAMINE BASE
- CBNumber:
- CB3192278
- Molecular Formula:
- C16H20N2
- Molecular Weight:
- 240.34
- MDL Number:
- MFCD00865659
- MOL File:
- 86-21-5.mol
| Melting point | <25 °C |
|---|---|
| Boiling point | bp13 181°; bp2 142°; bp0.5 135° |
| Density | 1.0081 |
| refractive index | nD25 1.5519 to 1.5521 |
| Flash point | 9℃ |
| storage temp. | -20°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Oil |
| pka | pKa 4.03± 0.08;9.32± 0.06(H2O,t undefined,I=0.30(NaCl)) (Uncertain) |
| color | Colourless |
| InChIKey | IJHNSHDBIRRJRN-UHFFFAOYSA-N |
| CAS DataBase Reference | 86-21-5(CAS DataBase Reference) |
| FDA UNII | 134FM9ZZ6M |
| ATC code | D04AA16,R06AB05 |
| NIST Chemistry Reference | Pyridine, 2[alpha-(2-dimethyl aminoethyl)benzyl](86-21-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS06,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H225-H301+H311+H331-H370 |
| Precautionary statements | P210-P260-P280-P301+P310-P311 |
| Hazard Codes | F,T |
| Risk Statements | 11-23/24/25-39/23/24/25 |
| Safety Statements | 16-36/37-45 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 1 |
Pheniramine price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P-045 | Pheniramine solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? | 86-21-5 | 1mL | $41.5 | 2024-03-01 | Buy |
| TRC | P297195 | Pheniramine | 86-21-5 | 250mg | $835 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb531229 | AVIL | 86-21-5 | 10μg | $1326 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 16868 | Pheniramine | 86-21-5 | 1mg | $525 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0009137 | PHENIRAMINE 95.00% | 86-21-5 | 250MG | $727.65 | 2021-12-16 | Buy |
Pheniramine Chemical Properties,Uses,Production
Originator
Trimeton Maleate, Schering ,US,1948
Uses
Pheniramine is an antigripal drug. Also, it is derived from 2-Benzylpyridine (B288740), which is a benzylpyridine with antifungal properties. 2-Benzylpyridine is also used as a chromogenic reagent for micro determination of Molybednum.
Definition
ChEBI: N,N-dimethyl-3-phenyl-3-(2-pyridinyl)-1-propanamine is a tertiary amino compound and a member of pyridines.
Manufacturing Process
According to US Patent 2,676,964: to 1.0 mol of potassium amide in 3 liters of liquid ammonia, is added 1.0 mol of 2-benzylpyridine. After 15 minutes, 1.1 mols of β-dimethylaminoethyl chloride are added. The ammonia is allowed to evaporate and the reaction product decomposed with water and ether extracted. The ether layer is dried over sodium sulfate and after evaporation the residue is distilled, giving the 3-phenyl-3-(2-pyridyl)-N,Ndimethylpropylamine, BP 139°-142°C/1-2 mm. The maleate is produced by reaction with maleic acid.
Therapeutic Function
Antihistaminic
Synthesis Reference(s)
The Journal of Organic Chemistry, 59, p. 7125, 1994 DOI: 10.1021/jo00102a044
Safety Profile
Poison by intravenous route. Human systemic effects by ingestion: central nervous system effects. When heated to decomposition it emits toxic fumes of NOx.
Enzyme inhibitor
This antihistamine (FWfree-base = 240.35 g/mol; CAS 86-21-5; insoluble in water; maleate and p-aminosalicylate salts are water-soluble), also known as N,N-dimethyl-g-phenyl-2-pyridinepropanamide, is more frequently abused than other antihistamines relative to its market share. One of the histamine H1 antagonists with little sedative action, pheniramine is often used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus. Target(s): H1 histamine receptor; and histamine Nmethyltransferase, mildly inhibited.
Pheniramine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3430 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9177 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28812 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. | +86-029-86185165 +8618629664246 | guoyuan@eastchinapharm.com | China | 1615 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 20000 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
View Lastest Price from Pheniramine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-20 | Pheniramine
86-21-5
|
US $1.00-1.00 / KG | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2021-06-17 | Pheniramine USP/EP/BP
86-21-5
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2019-09-02 | Pheniramine
86-21-5
|
US $7.00 / KG | 1KG | 99% | JD 486 | Career Henan Chemical Co |
-
- Pheniramine
86-21-5
- US $1.00-1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Pheniramine USP/EP/BP
86-21-5
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Pheniramine
86-21-5
- US $7.00 / KG
- 99%
- Career Henan Chemical Co