ChemicalBook >> CAS DataBase List >>Thiophene-2-ethylamine


Chemical Name:
2-(thiophen-2-yl)ethan-1-aMine;2-THIOPHENEETHYLAMINE;2-(2-AMINOETHYL)THIOPHENE;2-Thien-2-yL;ThiopheneEthaMine;RARECHEM AL BW 0099;2-Thiopheneethamine;2-Thiopheneethylamin;2-ThiophenethylaMine;THIOPHENE ETHYLAMINE
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
Last updated:2024-04-28 11:44:06

Thiophene-2-ethylamine Properties

Melting point 202 °C
Boiling point 200-201 °C/750 mmHg (lit.)
Density 1.087 g/mL at 25 °C (lit.)
refractive index n20/D 1.551(lit.)
Flash point 190 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO, Methanol
pka 9.47±0.10(Predicted)
form Liquid
Specific Gravity 1.087
color Colorless to yellow
Sensitive Air Sensitive
BRN 106962
CAS DataBase Reference 30433-91-1(CAS DataBase Reference)


Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338
Hazard Codes  Xn,Xi
Risk Statements  20/21/22-36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
HazardClass  IRRITANT
HazardClass  8
PackingGroup  II
HS Code  29339900
NFPA 704
3 0

Thiophene-2-ethylamine price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 423270 2-Thiopheneethylamine 96% 30433-91-1 1g $18 2024-03-01 Buy
Sigma-Aldrich 423270 2-Thiopheneethylamine 96% 30433-91-1 5g $148 2024-03-01 Buy
TCI Chemical A1637 2-(2-Aminoethyl)thiophene >98.0%(GC) 30433-91-1 25g $58 2024-03-01 Buy
TCI Chemical A1637 2-(2-Aminoethyl)thiophene >98.0%(GC) 30433-91-1 250g $365 2024-03-01 Buy
Alfa Aesar A10920 2-Thiopheneethylamine, 98% 30433-91-1 1g $35.65 2024-03-01 Buy
Product number Packaging Price Buy
423270 1g $18 Buy
423270 5g $148 Buy
A1637 25g $58 Buy
A1637 250g $365 Buy
A10920 1g $35.65 Buy

Thiophene-2-ethylamine Chemical Properties,Uses,Production

Chemical Properties

A colorless to yellow liquid with unstable properties requiring protection with nitrogen gas. It appears as a light yellow clear liquid, but turns red upon prolonged exposure.


[2-(Thiophene-2-yl)ethyl]amine is used in the synthesis of geldanamycin derivatives as HCV replication inhibitors targetting Hsp90.


2-Thiopheneethylamine (2-thiophene ethyl amine, 2-(thien-2-yl)ethylamine) is suitable to functionalize multiwall carbon nanotubes (MWCNT).
It may be used as a reactant in the synthesis of pyrimidine derivatives by reacting with various isothiocyanatoketones and acylguanidines derivatives by reacting with aroyl S-methylisothiourea.

General Description

2-Thiopheneethylamine (2-(thiophen-2-yl)ethanamine) is an aromatic amine. It undergoes microwave induced condensation with iminodiacetic acid to form the corresponding piperazine-2,6-dione derivatives. Its effect as a probable substitute to the pyridine ligand on the performance of poly(3-hexylthiophene)/CdSe hybrid solar cells has been investigated.


N,N-Dimethylformamide (DMF) reacts with thiophene to obtain 2-thiophenecarbaldehyde, then reacts with isopropyl chloroacetate to obtain 2-thiopheneacetaldehyde, and then reacts with hydroxylamine hydrochloride to obtain 2-thiopheneacetaldehyde oxime, and finally reduced to give 2-thiopheneethylamine.


[1] M. BARWIOLEK. Structural and spectral studies of silver(I) complexes with new Schiff bases derived from 2-thiopheneethylamine and their application in thin layer deposition by spin and dip coating techniques[J]. Polyhedron, 2017, 124: Pages 12-21. DOI:10.1016/j.poly.2016.12.011.
[2] BHUSHAN D. VARPE S B J. Schiff Base of Isatin with 2-Thiopheneethylamine and Its Mannich Bases: Synthesis, Docking, and In Vitro Anti-Inflammatory and Antitubercular Activity[J]. Russian Journal of Bioorganic Chemistry, 2022, 48 2: 372-379. DOI:10.1134/S1068162022020030.
[3] JUN YAN LEK. Understanding the Effect of Surface Chemistry on Charge Generation and Transport in Poly (3-hexylthiophene)/CdSe Hybrid Solar Cells[J]. ACS Applied Materials & Interfaces, 2011, 3 2: 287-292. DOI:10.1021/am100938f.
[4] SANDEEP KUMAR. Efficient synthesis of piperazine-2,6-dione and 4-(1H-indole-2-carbonyl)piperazine-2,6-dione derivatives and their evaluation for anticancer activity[J]. Medicinal Chemistry Research, 2013, 22 10: 4600-4609. DOI:10.1007/s00044-012-0438-7.

Synthesis of Thiophene-2-ethylamine from Thiophene, 2-(2-nitroethyl)-
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View Lastest Price from Thiophene-2-ethylamine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Thiopheneethylamine pictures 2023-09-18 2-Thiopheneethylamine
US $0.00 / kg 1kg 99% 20tons Hebei Yanxi Chemical Co., Ltd.
Thiophene-2-ethylamine pictures 2023-04-25 Thiophene-2-ethylamine
US $67.00 / kg 1kg 99% 5000 tons Hebei Duling International Trade Co. LTD
Thiophene-2-ethylamine pictures 2023-01-31 Thiophene-2-ethylamine
US $50.00 / KG 1KG 99% 20tons Hebei Mojin Biotechnology Co., Ltd
20(2-thienyl)ethylamine 2-(2'-Thienyl) ethyl amine/ Thiophene-2-ethylamine 2-(2-Aminoethyl)thiophene~Thiophene-2-ethylamine 2-Thiopheneethylamin Thiophene-2-Ethylamine ,99% 2-(2-Thienyl)ethanamine 2-Thiopheneethanamine Thiophene-2-ethanamine Thiophene-2-ethylamine,98% 2-Thiophen-2-ylethanamine 2-(2-thienyl)ethanamine(SALTDATA: FREE) 2-ThiophenethylaMine 2-(Thien-2-yl)ethylamine ThiopheneEthaMine [2-(Thiophene-2-yl)ethyl]aMine THIOPHENE ETHYLAMINE THIOPHENE-2-ETHYLAMINE THIOPHENE-2-ETHYLAMINE HCL SALT RARECHEM AL BW 0099 2-(2'-THIENYL)ETHYL AMINE 2-(2-THIENYL)ETHYLAMINE 2-(2-THIENYL)-1-ETHANAMINE 2-(2-THIENYL)-1-ETHANAMINE HYDROCHLORIDE 2-AMINOETHYLTHIOPHENE B-2-THIENYLETHYLAMINE .beta.-2-Thienylethylamine Thiophen-2-ylacetyl chloride 2-Thiopheneethamine 2-(2-Aminoethyl)thiophene > 2-Thien-2-yL Thiophene-2-ethylamine ISO 9001:2015 REACH 2-(thiophen-2-yl)ethan-1-aMine 2-(2-AMINOETHYL)THIOPHENE 2-THIOPHENEETHYLAMINE Rotigotine Impurity 17 30433-91-1 423-27-0 30433-14-3 C6H9SN AMINE Building Blocks Heterocyclic Building Blocks Thiophenes Building Blocks C4 to C6 Chemical Synthesis Heterocyclic Building Blocks Building Blocks Heterocyclic Building Blocks Thiophenes Amines Heterocyclic Compounds Ticlopidine Clopidogrel Anilines, Aromatic Amines and Nitro Compounds Thiophene&Benzothiophene