Chinese Japanese Germany


Peripheral vasodilator Chemical Properties Uses Production method
Chemical Name:
r516;r1575;R 516;Sepan;516md;Eglen;516 MD;R 1575;Artate;Glanil
Molecular Formula:
Formula Weight:
MOL File:

Stugeron Properties

Melting point:
Boiling point:
488.83°C (rough estimate)
1.1818 (rough estimate)
refractive index 
1.7620 (estimate)
storage temp. 
Soluble in chloroform at 50mg/ml
pKa 7.47(H2O t=25.0 ) (Uncertain)
CAS DataBase Reference
298-57-7(CAS DataBase Reference)
NIST Chemistry Reference


Hazard Codes  Xn
Risk Statements  20/22-36/37/38-42/43
Safety Statements  22-24/25-36-26
WGK Germany  2
RTECS  TL3430000

Stugeron price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C5270 Cinnarizine powder 298-57-7 10g $44.3 2018-11-13 Buy
Sigma-Aldrich C2180000 Cinnarizine European Pharmacopoeia (EP) Reference Standard 298-57-7 c2180000 $179 2018-11-23 Buy
TCI Chemical C3459 Cinnarizine >98.0%(HPLC)(N) 298-57-7 10g $47 2018-11-22 Buy
TCI Chemical C3459 Cinnarizine >98.0%(HPLC)(N) 298-57-7 50g $140 2018-11-22 Buy
Alfa Aesar J64568 Cinnarizine 298-57-7 25g $75 2018-11-13 Buy

Stugeron Chemical Properties,Uses,Production

Peripheral vasodilator

Stugeron is a piperazine calcium channel blockers, belonging to the peripheral vasodilator. It is white or white-like crystal or crystalline powder. It is odorless and almost tasteless. It is insoluble in water, soluble in boiling ethanol and easily soluble in chloroform or benzene. Stugeron has dilatation effect on the vascular smooth muscle and has antagonism effect on various kinds of vasoconstrictor substances such as serotonin, epinephrine, bradykinin and vasopressin, etc., it can ease the vasospasm. Its antispasmodic effect is stronger than papaverine with a not obvious sedative effect. This product can enables a significant increase in the cerebral blood flow and can significantly improve the cerebral circulation and coronary circulation with longer duration of action and has inhibitory effect on various kinds of vasoactive substances. It is capable of relieving vasospasm and preventing the embrittlement of the blood vessel. In the situation of not affecting heart rate and oxygen consumption, it can increase the coronary blood flow and cardiac output. Intravenous injection of this product can cause short period of blood pressure drop while oral administration has no such effect. In addition, this product also has effect on preventing embrittlement of the blood vessel as well as anti-histamine effect.
It will onset within 30 minutes after oral administration with the plasma concentration reaching peak within 3-7 hours. The effect can last for four hours with the half-life of plasma concentration being 3 to 24 hours.
Clinically Stugeron is mainly used for the treatment of peripheral vascular disease and cerebrovascular disorders such as cerebral embolism, cerebral thrombosis, cerebral arteriosclerosis and hypertension induced circulation insufficiency, cerebral hemorrhage, subarachnoid hemorrhage convalescence and sequelae of traumatic brain injury. It also has efficacy in treating the mental neuropathy and coronary sclerosis. It can also be used for treating the inner ear vertigo and nausea, vomiting and motion sickness caused by other disorders.
The main adverse reactions of Stugeron: occasionally drowsiness, rash, gastrointestinal reactions, dizziness, fever or flu, intravenous blood pressure can cause short-term decline of the blood pressure; pregnant women should take with caution; patients of intracranial hemorrhage and acute cerebral infarction should be hanged.
The above information is edited by the Chemicalbook of Dai Xiongfeng.

Chemical Properties

Stugeron hydrochloride, C26H28N2 • 2HCI, [7002-58-6], melting point 192 ℃, the solubility in water is 2mg/100ml.


It is long-efficacy, multifunction vasoconstriction antagonists. It can dilate blood vessels, improve blood circulation and prevent blood vessel embrittlement. It can be used in the treatment of cerebral vascular diseases as well as has efficacy in treating cervical vertigo caused headaches, dizziness, insomnia, memory loss, paralysis, numbness, weakness and slurred speech embolism.

Production method

It can be produced through: first use anhydrous piperazine and brominated diphenyl methane for preparation of benzhydryl piperazine, then condense with chlorine allyl benzene to obtain it. Diphenyl methane was heated in the light, add bromine and incubate for 1h at 130 ℃ which generates brominated diphenyl methane, C13H11Br, [776-74-9] with the melting point of 45 ℃. Add the brominated diphenyl methane drop wise into the piperazine toluene and stir for 3h at 80-90 ℃, further wash with water after cooling, then use 10% dilute hydrochloric acid for extraction; The acid layer was basified for being precipitated, filtered and dried to give benzhydryl piperazine. Dissolve it in 95% ethanol, add sodium carbonate and add drop wise of allyl benzene at about 65 ℃, after the completion of the dropping, heat and reflux for 4h, filter hot and the filtrate was left overnight for precipitate the crystalline, filter to get the crude product of Stugeron which under refinement become finished product with melting point of 117-119 ℃. In terms of diphenyl methane, the total yield is 48.2%.

Chemical Properties

White or almost white powder.


Calcium channel blocker with antiallergic and anti-vasoconstricting activity. Antihistaminic


glucocorticoid, antiinflammatory


Histamine H1 receptor antagonist; antihistamine.


For the treatment of vertigo/meniere's disease, nausea and vomiting, motion sickness and also useful for vestibular symptoms of other origins.

Stugeron Preparation Products And Raw materials

Raw materials

Preparation Products

Stugeron Suppliers

Global( 151)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32764 55
Meihua Biological Technology Co.,Ltd
031145896235 CHINA 216 58
career henan chemical co
+86-371-86658258 CHINA 20001 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038 CHINA 3624 58
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611
+86 21 50676805 China 9975 58
Foshan DaoQi Biological Co., Ltd. 15372409258
0571-87068629 China 2928 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933; China 96815 76
INTATRADE GmbH +49 3493/605464
+49 3493/605470 Germany 3587 66
TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
021-67121385 China 24654 81
Beijing Ouhe Technology Co., Ltd +86-10-4006331231;+86-10-51280831;+86-10-82967028
+86-10-82967029 China 12609 60

View Lastest Price from Stugeron manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-15 Stugeron
US $1.00 / kg 1kg 99% Customized career henan chemical co
2018-05-30 Cinnarizine
US $1.00 / G 1G 99.5% 100000 Meihua Biological Technology Co.,Ltd

298-57-7(Stugeron)Related Search:

  • 1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-piperazin
  • 1-Benzhydryl-4-[(2E)-3-phenyl-2-propenyl]piperazine
  • 1-cinnamyl-4-(diphenylmethyl)-piperazin
  • 1-Cinnamyl-4-(diphenylmethyl)piperazine
  • 1-cinnamyl-4-(diphenylmethyl)-Piperazine
  • 1-Cinnamyl-4-diphenylmethylpiperazine
  • 516 MD
  • Processine
  • R 1575
  • R 516
  • r1575
  • r516
  • 516md
  • Aplactan
  • Aplexal
  • Sedatromin
  • Sepan
  • Siptazin
  • Spaderizine
  • Stutgeron
  • Stutgin
  • Toliman
  • trans-1-Cinnamyl-(4-diphenylmethyl)piperazine
  • stugeron
  • 1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-piperazine
  • Apotomin
  • Artate
  • Carecin
  • Cerebolan
  • Cinaperazine
  • Cinazyn
  • Cinnacet
  • Cinnageron
  • component of Emesazine
  • Corathiem
  • Denapol
  • Dimitron
  • Dimitronal
  • Eglen
  • Folcodal
  • Giganten
  • Glanil
  • Hilactan
  • Ixertol
  • Katoseran
  • Labyrin
  • Lazeta
  • Marisan
  • Midronal
  • Mitronal
  • Olamin
  • Piperazine, 1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-
  • Piperazine, 1-cinnamyl-4-(diphenylmethyl)-
  • Piperazine,1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-(9CI)
  • Piperazine,1-cinnamyl-4-(diphenylmethyl)-
Copyright 2017 © ChemicalBook. All rights reserved