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Linaclotide

Linaclotide
Linaclotide structure
CAS No.
851199-59-2
Chemical Name:
Linaclotide
Synonyms
Linaelotide;Linaclotide;Linacllotide;Linaelotide Acetate
CBNumber:
CB82498818
Molecular Formula:
C59H79N15O21S6
Formula Weight:
1526.73646
MOL File:
851199-59-2.mol

Linaclotide Properties

Boiling point:
2045.0±65.0 °C(Predicted)
Density 
1.60
pka
3.05±0.10(Predicted)
FDA UNII
N0TXR0XR5X

Linaclotide price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 24085 Linaclotide ≥95% 851199-59-2 500μg $25 2018-11-19 Buy
Cayman Chemical 24085 Linaclotide ≥95% 851199-59-2 1mg $45 2018-11-19 Buy
Cayman Chemical 24085 Linaclotide ≥95% 851199-59-2 5mg $150 2018-11-19 Buy
Cayman Chemical 24085 Linaclotide ≥95% 851199-59-2 10mg $270 2019-12-02 Buy

Linaclotide Chemical Properties,Uses,Production

Description

In August 2012, the US FDA approved linaclotide (also referred to as MD-1100), a first-in-class, orally administered 14-amino acid peptide as a therapy for patients suffering from chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). Linaclotide and its active metabolite MM-419447, which results from the cleavage of the C-terminal tyrosine residue by carboxypeptidase A, mimic the actions of the endogenous intestinal peptides guanylin (15 amino acids) and uroguanylin (16 amino acids) by activating guanylyl cyclase C (GC-C) on the intestinal epithelium. Activation of GC-C leads to increased intra- and extracellular levels of cGMP and activation of the CFTR ion channel, resulting in increased levels of HCO3-, Cl-, and water in the intestinal lumen and accelerated gastrointestinal transit. Based on an in vitro assaymeasuring the accumulation of cGMP in T84 cell exposed to an agonist, the EC50 of linaclotide at pH 7.0 was 99±17.5 nM. In preclinical studies in mice using the transit of activated charcoal as ameasure of efficacy, linaclotide at 100 μg/kg significantly accelerated transit compared to wild-type mice treated with charcoal only or GC-Cnullmice treatedwith and without linaclotide.118 Efficacy was also seen in rats treatedwith linaclotide atdoses of 5, 10, and 20 μg/kg. Linaclotide has been synthesized using conventional solid-phase peptide technology.

Originator

Ironwood Pharmaceuticals and Forest Pharmaceuticals (United States)

brand name

Linzess

Linaclotide Preparation Products And Raw materials

Raw materials

Preparation Products


Linaclotide Suppliers

Global( 106)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Alpha Biopharmaceuticals Co., Ltd
0086-411-39042497
0086-411-39042693 sales@alphabiopharm.com China 921 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21829 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
Rixing Chemical CO.,LTD
13237129059
- info@rixingchemi.com CHINA 228 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24698 60
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 969 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2645 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 914 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6372 58

View Lastest Price from Linaclotide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-02-18 Linaclotide
851199-59-2
US $7.00 / KG 1KG 99% 100kg Career Henan Chemical Co
2019-07-23 Linaclotide
851199-59-2
US $1.00 / g 1g 99% 20 Metric Ton/Metric Tons per Month Cangzhou Wanyou New Material Technology Co.,Ltd

851199-59-2(Linaclotide)Related Search:


  • Linacllotide
  • Linaclotide
  • Linaelotide Acetate
  • Linaelotide
  • 851199-59-2
  • C59H79N15O21S6
  • C59H78N16O22S6
  • Inhibitors
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