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Linaclotide

Linaclotide
Linaclotide structure
CAS No.
851199-59-2
Chemical Name:
Linaclotide
Synonyms
CY-14;Argpessin;Liclotide;Linaelotide;Linaclotide;Linacllotide;Linaelotide Acetate;Rinalodipine Acetate;Linaclotide USP/EP/BP;L-Tyrosine, L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (1→6),(2→10),(5→13)-tris(disulfide)
CBNumber:
CB82498818
Molecular Formula:
C59H79N15O21S6
Formula Weight:
1526.74
MOL File:
851199-59-2.mol

Linaclotide Properties

Boiling point:
2045.0±65.0 °C(Predicted)
Density 
1.60
pka
3.05±0.10(Predicted)
FDA UNII
N0TXR0XR5X
ATC code
A06AX04

Linaclotide price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 24085 Linaclotide ≥95% 851199-59-2 500μg $25 2021-12-16 Buy
Cayman Chemical 24085 Linaclotide ≥95% 851199-59-2 1mg $45 2021-12-16 Buy
TRC L465880 Linaclotide 851199-59-2 100mg $1540 2021-12-16 Buy
Biorbyt Ltd orb611326 Linaclotide 851199-59-2 250 mg $2097.8 2021-12-16 Buy
Medical Isotopes, Inc. 47117 Linaclotide 851199-59-2 100 mg $2400 2021-12-16 Buy

Linaclotide Chemical Properties,Uses,Production

Description

In August 2012, the US FDA approved linaclotide (also referred to as MD-1100), a first-in-class, orally administered 14-amino acid peptide as a therapy for patients suffering from chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). Linaclotide and its active metabolite MM-419447, which results from the cleavage of the C-terminal tyrosine residue by carboxypeptidase A, mimic the actions of the endogenous intestinal peptides guanylin (15 amino acids) and uroguanylin (16 amino acids) by activating guanylyl cyclase C (GC-C) on the intestinal epithelium. Activation of GC-C leads to increased intra- and extracellular levels of cGMP and activation of the CFTR ion channel, resulting in increased levels of HCO3-, Cl-, and water in the intestinal lumen and accelerated gastrointestinal transit. Based on an in vitro assaymeasuring the accumulation of cGMP in T84 cell exposed to an agonist, the EC50 of linaclotide at pH 7.0 was 99±17.5 nM. In preclinical studies in mice using the transit of activated charcoal as ameasure of efficacy, linaclotide at 100 μg/kg significantly accelerated transit compared to wild-type mice treated with charcoal only or GC-Cnullmice treatedwith and without linaclotide.118 Efficacy was also seen in rats treatedwith linaclotide atdoses of 5, 10, and 20 μg/kg. Linaclotide has been synthesized using conventional solid-phase peptide technology.

Originator

Ironwood Pharmaceuticals and Forest Pharmaceuticals (United States)

Uses

Linaclotide is a guanylate cyclase-C agonist currently being studied in Phase 3 trials for the treatment of irritable bowel syndrome with constipation.

brand name

Linzess

Linaclotide Preparation Products And Raw materials

Raw materials

Preparation Products


Linaclotide Suppliers

Global( 167)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
AFINE CHEMICALS LIMITED
008657185134551
008657185134895 info@afinechem.com CHINA 15559 58
Hangzhou Go Top Peptide Biotech
0571-88211921
sales1@gotopbio.com CHINA 2610 58
Alpha Biopharmaceuticals Co., Ltd
0086-411-39042497
0086-411-39042693 sales@alphabiopharm.com China 896 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Rixing Chemical CO.,LTD
13237129059
- info@rixingchemi.com CHINA 229 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26782 60
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 968 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com CHINA 2712 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 914 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58

View Lastest Price from Linaclotide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-01-19 Linaclotide
851199-59-2
US $1.00 / g 10g 99.5% 1000kg Guangzhou Biocar Biotechnology Co.,Ltd.
2021-11-30 Linaclotide
851199-59-2
US $2270.00 / g 1g 98% 1-20mt Baoji Guokang Bio-Technology Co., Ltd.
2021-11-09 Linaclotide
851199-59-2
US $0.00 / Kg/Bag 2Kg/Bag 98% up 20 tons Sinoway Industrial co., ltd.

851199-59-2(Linaclotide)Related Search:


  • Linacllotide
  • Linaclotide
  • Linaelotide Acetate
  • Linaelotide
  • CY-14
  • Liclotide
  • Argpessin
  • L-Tyrosine, L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (1→6),(2→10),(5→13)-tris(disulfide)
  • Linaclotide USP/EP/BP
  • Rinalodipine Acetate
  • 851199-59-2
  • C59H79N15O21S6
  • C59H78N16O22S6
  • Inhibitors
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