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Fexofenadine hydrochloride

Fexofenadine hydrochloride 구조식 이미지
카스 번호:
153439-40-8
상품명:
Fexofenadine hydrochloride
동의어(영문):
Fexo;Allegra;Telfast;Alernex;Feksine;Fexofen;Fexadyne;Vivafeks;MDL 16455A;Telfast BD
CBNumber:
CB0256621
분자식:
C32H40ClNO4
포뮬러 무게:
538.12
MOL 파일:
153439-40-8.mol

Fexofenadine hydrochloride 속성

녹는점
148-150oC
RTECS 번호
CY1633377
저장 조건
−20°C
용해도
Soluble in Dimethyl sulfoxide (50 mM), and methanol.
물리적 상태
powder
색상
white to beige
Merck
14,4068
InChIKey
RRJFVPUCXDGFJB-UHFFFAOYSA-N
CAS 데이터베이스
153439-40-8(CAS DataBase Reference)

안전

위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 26-36
WGK 독일 3
HS 번호 2933399090

Fexofenadine hydrochloride C화학적 특성, 용도, 생산

화학적 성질

Off-White Crystalline Solid

용도

A metabolite of of terfenadine, a H1-Histamine receptor antagonist

용도

The active metabolite of Terfenadine (T114500), a H1-histamine receptor antagonist.

용도

Antihistaminic;histamine H1-receptor antagonist

용도

Fexofenadine is a non-sedating antihistamine that selectively antagonizes the histamine H1 receptor with a Ki value of 10 nM and exhibits anti-inflammatory effects. It is devoid of central nervous system effects in part because it is a good substrate for the P-glycoprotein efflux pump situated within the blood-brain barrier.[Cayman Chemical]

일반 설명

Fexofenadine hydrochloride, (±)-4-[1-hydroxy-4-[4-(hydroxyldiphenylmethyl)- 1-piperinyl]butyl-α,α-dimethylbenzeneacetic acid (Allegra), occurs as a white to off-white crystalline powder that is freely soluble in methanol and ethanol, slightly soluble in chloroform and water, and insoluble in hexane.
This compound is marketed as a racemate and exists as a zwitterion in aqueous media at physiological pH. Fexofenadine is a primary oxidative metabolite of terfenadine. Terfenadine was developed during a search for new butyrophenone antipsychotic drugs as evidenced by the presence of the N-phenylbutanol substituent. It also contains a diphenylmethyl-piperidine moiety analogous to that found in the piperazine antihistamines.

생물학적 활성

Selective histamine H 1 receptor antagonist (pK i = 8.1). Active metabolite of terfenadine that displays non-sedating antiallergic effects.牋.

Fexofenadine hydrochloride 준비 용품 및 원자재

원자재

준비 용품


Fexofenadine hydrochloride 공급 업체

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