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Epothilone B

Epothilone B 구조식 이미지
카스 번호:
152044-54-7
상품명:
Epothilone B
동의어(영문):
EPO 906A;atupilone;Patupilone;EPOTHILONE;Epothilone B;Epothilone B, >=98%;Epothilone B(EPO906);Patupilone(Epothilone B);Epothilone B(Patupilone);EPO906, EpoB, Patupilone
CBNumber:
CB0972824
분자식:
C27H41NO6S
포뮬러 무게:
507.68
MOL 파일:
152044-54-7.mol

Epothilone B 속성

녹는점
95-97°C
알파
D21 -35° (c = 0.7 in methanol)
밀도
1.136
저장 조건
Store at -20°C
물리적 상태
White to off-white solid
색상
colorless
InChIKey
QXRSDHAAWVKZLJ-PVYNADRNSA-N
CAS 데이터베이스
152044-54-7

안전

WGK 독일 3
HS 번호 29419090

Epothilone B C화학적 특성, 용도, 생산

화학적 성질

White Powder

용도

Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone B is what is known as a microtubule stabilizer. When a cell divides, the chromosomes that will end up in each cell are separated by thin filaments called microtubules. Normally these microtubules then break down as the cell division progresses. This class of cytotoxic chemo drugs prevents that break down and thus prevents cells from completing division.

용도

Epothilone B is a microtubule inhibitor isolated from the myxobacteria, Sorangium cellulosum. Like epothilone A, epothilone B acts by stabilising microtubule formation at the taxol binding site, and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity.

용도

Epothilone B (Epo B) is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis. It induces mitotic arrest at the G2-M transition in Hs578T and HeLa cells (IC50 = 3 and 32 nM, respectively) as well as in multidrug resistant KB3-1 and KBV-1 cells (IC50 = 16 and 92 nM, respectively). Epo B causes cell cycle arrest at nanomolar IC50 values in cell lines from ovarian, breast, lung, colon, prostate, and squamous cancer.

정의

ChEBI: An epithilone that is epithilone D in which the double bond in the macrocyclic ring has been oxidised to the corresponding epoxide (the S,S stereoisomer).

생물학적 활성

Microtubule stabilization agent that promotes tubulin polymerization and induces G 2 -M cell cycle arrest (EC 50 = 3 - 92 nM). Potently inhibits a variety of human cancer cell lines (IC 50 values are 0.13 - 0.64 nM), including MDR cells overexpressing the P-glycoprotein efflux pump. Exhibits potent anticancer activity in numerous human tumor xenografts in vivo .

Epothilone B 준비 용품 및 원자재

원자재

준비 용품


Epothilone B 공급 업체

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Hubei Jusheng Technology Co.,Ltd.
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QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8409 58
career henan chemical co
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sales@coreychem.com CHINA 20331 58
Chembest Research Laboratories Limited +86(0)21-20908456
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CEG Chemical Science&Technology Co., Ltd. Mobile:13665161512
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