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1,2,4-트라이클로로벤젠

1,2,4-트라이클로로벤젠
1,2,4-트라이클로로벤젠 구조식 이미지
카스 번호:
120-82-1
한글명:
1,2,4-트라이클로로벤젠
동의어(한글):
1,2,4-트라이클로로벤젠;1,2,4-트라이클로로벤젠(1,2,4-트리클로로벤젠);1,2,4-트리클로로벤젠;1,2,4-트라이클로로벤졸;1,2,5-트라이클로로벤젠;1,3,4-트라이클로로벤젠;unsym-트라이클로로벤젠;벤젠, 1,2,4-트라이클로로-;클로리네이티드 벤젠
상품명:
1,2,4-Trichlorobenzene
동의어(영문):
ai3-07775;1.2.4-Tric;1,2,4TrichL;Hipochem GM;hostetexl-pec;Hostetex l-pec;Trojchlorobenzen;as-trichlorobenzene;1,2,4-Trichlorobenze;1,2,4-Trichlorbenzol
CBNumber:
CB8852926
분자식:
C6H3Cl3
포뮬러 무게:
181.45
MOL 파일:
120-82-1.mol

1,2,4-트라이클로로벤젠 속성

녹는점
16 °C(lit.)
끓는 점
214 °C(lit.)
밀도
1.454 g/mL at 25 °C(lit.)
증기 밀도
>6 (vs air)
증기압
1 mm Hg ( 40 °C)
굴절률
n20/D 1.571(lit.)
인화점
>230 °F
저장 조건
2-8°C
용해도
water: insoluble
물리적 상태
Liquid
색상
Clear
냄새
Characteristic aromatic odor
폭발한계
6.6%, 150°F
수용성
INSOLUBLE
최대 파장(λmax)
λ: 308 nm Amax: 1.00
λ: 310 nm Amax: 0.50
λ: 350 nm Amax: 0.05
λ: 375-400 nm Amax: 0.01
Merck
14,9631
BRN
956819
Henry's Law Constant
0.997 at 20.0 °C (wetted-wall column, ten Hulscher et al., 1992) 1.24, 2.27, 2.58, 3.06, and 3.90 at 2.0, 6.0, 10.0, 18.0, and 25.0 °C, respectively (EPICS-SPME, Dewulf et al., 1999)
노출 한도
NIOSH REL: TWA ceiling 5 ppm (40 mg/m3); ACGIH TLV: ceiling 5 ppm (adopted).
안정성
Stable. Incompatible with strong oxidizing agents. Combustible.
CAS 데이터베이스
120-82-1(CAS DataBase Reference)
NIST
Benzene, 1,2,4-trichloro-(120-82-1)
EPA
1,2,4-Trichlorobenzene (120-82-1)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,N,Xi,T,F
위험 카페고리 넘버 22-38-50/53-52/53-39/23/24/25-23/24/25-11-51/53
안전지침서 23-37/39-60-61-45-36/37-16-7
유엔번호(UN No.) UN 2321 6.1/PG 3
WGK 독일 3
RTECS 번호 DC2100000
자연 발화 온도 571 °C
위험 참고 사항 Irritant
TSCA Yes
위험 등급 6.1
포장분류 III
HS 번호 29036990
유해 물질 데이터 120-82-1(Hazardous Substances Data)
독성 LD50 orally in Rabbit: 550 mg/kg LD50 dermal Rat 6139 mg/kg
기존화학 물질 KE-34063
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H225 고인화성 액체 및 증기 인화성 액체 구분 2 위험 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H370 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킴(노출되어도 특정 표적장기 독성을 일으키지 않는다는 결정적인 노출경로가 있다면 노출경로를 기재) 특정 표적장기 독성 - 1회 노출 구분 1 위험 P260, P264, P270, P307+P311, P321,P405, P501
H400 수생생물에 매우 유독함 수생 환경유해성 물질 - 급성 구분 1 경고 P273, P391, P501
H410 장기적 영향에 의해 수생생물에 매우 유독함 수생 환경유해성 물질 - 만성 구분 1 경고 P273, P391, P501
H411 장기적 영향에 의해 수생생물에 유독함 수생 환경유해성 물질 - 만성 구분 2
예방조치문구:
P210 열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P260 분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P273 환경으로 배출하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P311 의료기관(의사)의 진찰을 받으시오.
P321 (…) 처치를 하시오.
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P332+P313 피부 자극이 생기면 의학적인 조치· 조언을 구하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.
NFPA 704
1
2 0

1,2,4-트라이클로로벤젠 MSDS


1,2,4-Trichlorobenzene

1,2,4-트라이클로로벤젠 C화학적 특성, 용도, 생산

개요

Trichlorobenzenes (TCBs) are synthetic chemicals that occur in three different isomeric forms. The three chlorinated cyclic aromatic isomers are 1,2,3-trichlorobenzene (1,2,3-TCB), 1,2,4-trichlorobenzene (1,2,4-TCB), and 1,3,5-trichlorobenzene (1,3,5-TCB). 1,2,4-TCB is one of the 188 chemicals designated as a hazardous air pollutant under the Clean Air Act.

화학적 성질

Colorless, stable liquid; odor similar to that of o-dichlorobenzene. Miscible with most organic solvents and oils; insoluble in water. Combustible.

화학적 성질

1,2,4-Trichlorobenzene is a low-melting solid or liquid with a pleasant, aromatic odor. The Odor Threshold is 1.4 ppm.

물리적 성질

Colorless liquid with an odor similar to o-dichlorobenzene. Odor threshold concentration is 1.4 (quoted, Amoore and Hautala, 1983).

용도

Trichlorobenzenes are primarily used as solvents in chemical manufacturing industries. 1,2,4-Trichlorobenzene is economically the most important isomer. 1,2,4-Trichlorobenzene is used as a solvent in chemical reactions to dissolve oils, waxes, and resins. Furthermore, it is also used as a dye carrier. 1,2,3- Trichlorobenzene is used as an intermediate for pesticides production, pigments, and dyes. 1,3,5-Trichlorobenzene is not marketed commercially and has very limited use as a chemical intermediate. Besides, trichlorobenzenes can also be used as degreasing agents, as septic tanks and drain cleaners, and as an ingredient in wood preservatives and abrasive formulations. Other minor uses include metal work, anticorrosive paint, and corrosion inhibitor in sprays. In the past, mixed isomers of trichlorobenzenes were used to control termites; however, their use has been discontinued.

용도

1,2,4-Trichlorobenzene is a solvent in various organic chemical reactions.

용도

1,2,4-Trichlorobenzene is used as a dielectric and heat transfer fluid in transformers. It acts as an intermediate, degreaser, wood preservative and solvent for dye. It is a high-temperature solvent used in gel permeation chromatography, especially for polyethylene and polypropylene. Further, it is used as a lubricant and as a synthetic transformer oil.

정의

ChEBI: A trichlorobenzene with chloro substituents at positions 1, 2 and 4.

Synthesis Reference(s)

Journal of the American Chemical Society, 74, p. 3890, 1952 DOI: 10.1021/ja01135a052

일반 설명

Colorless liquid or white solid with a sharp chlorobenzene odor. Melting point 16.95°C (62.5°F) .

반응 프로필

1,2,4-Trichlorobenzene can react vigorously with oxidizing materials . Yields hydrogen chloride and phosgene when heated to decomposition [USCG, 1999].

건강위험

Exposures to high concentrations via inhalation are potentially hazardous to the lungs, kidneys and liver. Prolonged or repeated exposures or short exposure to high concentrations via inhalation are potentially hazardous to the lungs, kidneys and liver. Prolonged or repeated exposure to the eyes is likely to result in moderate pain and transient irritation. Prolonged or repeated contact with the skin may result in moderate irritation and possible systemic effects. Ingestion: May cause kidney and liver damage.

Safety Profile

Poison by ingestion. Moderately toxic by intraperitoneal route. An experimental teratogen. Experimental reproductive effects. Mutation data reported. A slan irritant. Combustible when exposed to heat or flame. Can react vigorously with oxidizing materials. To fight fire, use water, foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of Cl-. See also CHLORINATED HYDROCARBONS, AROMATIC.

잠재적 노출

1,2,4-Trichlorobenzene is used as a dye carrier, herbicide intermediate; a heat transfer medium; a dielectric fluid in transformers; a degreaser; a lubricant; as an industrial chemical; solvent, emulsifier, and as a potential insecticide against termites. The other trichlorobenzene isomers are not used in any quantity.

환경귀착

Biological. Under aerobic conditions, biodegradation products may include 1,2-dichlorobenzene, 1,3-dichlorobenzene, 1,4-dichlorobenzene, and carbon dioxide (Kobayashi and Rittman, 1982). A mixed culture of soil bacteria or a Pseudomonas sp. transformed 1,2,4-trichlorobenzene to 2,4,5- and 2,4,6-trichlorophenol (Ballschiter and Scholz, 1980). When 1,2,4- trichlorobenzene was statically incubated in the dark at 25 °C with yeast extract and settled domestic wastewater inoculum, significant biodegradation occurred, with gradual acclimation followed by a deadaptive process in subsequent subcultures. At a concentration of 5 mg/L, 54, 70, 59, and 24% losses were observed after 7, 14, 21, and 28-d incubation periods, respectively. At a concentration of 10 mg/L, only 43, 54, 14, and 0% were observed after 7, 14, 21, and 28-d incubation periods, respectively (Tabak et al., 1981). In activated sludge, <0.1% mineralized to carbon dioxide after 5 d (Freitag et al., 1985).
In an enrichment culture derived from a contaminated site in Bayou d’Inde, LA, 1,2,4- trichlorobenzene underwent reductive dechlorination to 1,3- and 1,4-dichlorobenzene at relative molar yields of 4 and 96%, respectively. The maximum dechlorination rate, based on the recommended Michaelis-Menten model, was 4.6 nM/d (Pavlostathis and Prytula, 2000).
Surface Water. Estimated half-lives of 1,2,4-trichlorobenzene (0.5 μg/L) from an experimental marine mesocosm during the spring (8–16 °C), summer (20–22 °C), and winter (3–7 °C) were 22, 11, and 12 d, respectively (Wakeham et al., 1983).
Photolytic. A carbon dioxide yield of 9.8% was achieved when 1,2,4-trichlorobenzene adsorbed on silica gel was irradiated with light (λ >290 nm) for 17 h (Freitag et al., 1985).
Chemical/Physical. The hydrolysis half-life was estimated to be >900 yr (Ellington et al., 1988). At 70.0 °C and pH values of 3.10, 7.11, and 9.77, the hydrolysis half-lives were calculated to be 18.4, 6.6, and 5.9 d, respectively (Ellington et al., 1986).
At influent concentrations of 1.0, 0.1, 0.01, and 0.001 mg/L, the GAC adsorption capacities were 157, 77.6, 38.4, and 19.0 mg/g, respectively (Dobbs and Cohen, 1980).

운송 방법

UN2321 Trichlorobenzenes, liquid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

Separate it from a mixture of isomers by washing with fuming H2SO4, then water, drying with CaSO4 and slowly fractionally distilling. [Jensen et al. J Am Chem Soc 81 3303 1959, Beilstein 5 IV 664.]

Toxicity evaluation

The liver is themain target of trichlorobenzenes irrespective of the route of exposure. The mechanisms of liver toxicity induced by these chemicals have not been illustrated. It might involve intermediate arene oxides formed during initial transformation to trichlorophenols. In addition, exposure to 1,2,4-TCB induced porphyria in rats by inducing daminolevulinic acid (ALA) synthetase, a rate-limiting enzyme in the biosynthesis of heme, and also heme oxygenase, a ratelimiting enzyme in the degradation of heme synthetase, and therefore increasing heme production.

비 호환성

Reacts violently with oxidants, acids, acid fumes; steam.

폐기물 처리

Incineration, preferably after mixing with another combustible fuel. Care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove the halo acids produced.

1,2,4-트라이클로로벤젠 준비 용품 및 원자재

원자재

준비 용품


1,2,4-트라이클로로벤젠 공급 업체

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