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Biperiden hydrochloride

Biperiden hydrochloride
Biperiden hydrochloride structure
CAS No.
1235-82-1
Chemical Name:
Biperiden hydrochloride
Synonyms
Bicamol;Akiriden;Tasmolin;NSC 84989;NSC 170950;BIPERIDINE HCL;Biperidene HCL;akinetonhydrochloride;BIPERIDEN HYDROCHLORIDE;biperidinehydrochloride
CBNumber:
CB2726050
Molecular Formula:
C21H30ClNO
Formula Weight:
347.92
MOL File:
1235-82-1.mol

Biperiden hydrochloride Properties

Melting point:
238°
storage temp. 
Desiccate at +4°C
solubility 
DMSO: >20mg/mL
form 
powder
color 
off-white
NIST Chemistry Reference
Akineton, hydrochloride(1235-82-1)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  22-R22
WGK Germany  3
RTECS  TN3706000
Toxicity LD50 in rats, dogs (mg/kg): 750, 340 orally (Hanna)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Biperiden hydrochloride price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B1120000 Biperiden hydrochloride European Pharmacopoeia (EP) Reference Standard 1235-82-1 b1120000 $179 2018-11-23 Buy
Cayman Chemical 23775 Biperiden (hydrochloride) ≥95% 1235-82-1 5mg $35 2018-11-19 Buy
Cayman Chemical 23775 Biperiden (hydrochloride) ≥95% 1235-82-1 10mg $67 2018-11-19 Buy
Cayman Chemical 23775 Biperiden (hydrochloride) ≥95% 1235-82-1 25mg $158 2018-11-19 Buy
Cayman Chemical 23775 Biperiden (hydrochloride) ≥95% 1235-82-1 50mg $280 2018-11-19 Buy

Biperiden hydrochloride Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

A muscarinic receptor antagonist

Uses

Biperiden hydrochloride is antiparkinsonian; non-selective muscarinic receptor antagonist. Biperiden is used for the adjunctive treatment of all forms of Parkinson′s Disease (postencephalitic, idiopathic, and arteriosclerotic); also commonly used to improve parkinsonian signs and symptoms related to antipsychotic drug therapy.

Uses

Antiparkinsonian;Anticholinergic

Definition

ChEBI: The hydrochloride salt of biperiden. A muscarinic antagonist affecting both the central and peripheral nervous systems, it is used in the treatment of all forms of Parkinson's disease.

brand name

Akineton (Abbott).

General Description

Biperiden hydrochloride,α-5-norbornen-2-yl- -phenyl-1-piperidinepropanolhydrochloride (Akineton hydrochloride), is a white, opticallyinactive, crystalline, odorless powder that is slightlysoluble in water, ether, alcohol, and chloroform and sparinglysoluble in methanol.

Biological Activity

Muscarinic receptor antagonist that displays some selectivity for the M 1 subtype (K i values are 0.48, 2.4, 3.9, 6.3 and 6.3 nM for M 1 , M 4 , M 3 , M 2 and M 5 receptors respectively). Alleviates extrapyramidal symptoms associated with antipsychotic drugs. Displays antiparkinsonian activity.

Clinical Use

Biperiden hydrochloride has all of the actions describedfor biperiden. The hydrochloride is used for tablets becauseit is better suited to this dosage form than is the lactate salt.As with the free base and the lactate salt, xerostomia (drynessof the mouth) and blurred vision may occur.

Biperiden hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Biperiden hydrochloride Suppliers

Global( 61)Suppliers
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