Bipariden | 514-65-8

Bipariden Properties

Melting point	114°C
Boiling point	451.49°C (rough estimate)
Density	1.0202 (rough estimate)
refractive index	1.5614 (estimate)
storage temp.	2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly,Sonicated), Methanol (Slightly, Sonicated)
form	Solid
pka	14.05±0.29(Predicted)
color	White to Off-White
Water Solubility	25.1 mg/L
EWG's Food Scores	1
FDA UNII	0FRP6G56LD
ATC code	N04AA02
NIST Chemistry Reference	Biperiden(514-65-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338
Toxicity	LD50 in mice (mg/kg): 195 s.c., 56 i.v. (Klavehn)

Bipariden price More Price(11)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	B397820	Biperiden	514-65-8	50mg	$160	2021-12-16	Buy
Biorbyt Ltd	orb611544	Bipariden	514-65-8	50mg	$224.4	2021-12-16	Buy
AK Scientific	P695	Biperiden	514-65-8	5mg	$34	2021-12-16	Buy
American Custom Chemicals Corporation	API0009339	BIPERIDEN 95.00%	514-65-8	100MG	$329.7	2021-12-16	Buy
Biorbyt Ltd	orb611544	Bipariden	514-65-8	100mg	$345.1	2021-12-16	Buy

Product number	Packaging	Price	Buy
B397820	50mg	$160	Buy
orb611544	50mg	$224.4	Buy
P695	5mg	$34	Buy
API0009339	100MG	$329.7	Buy
orb611544	100mg	$345.1	Buy

Bipariden Chemical Properties,Uses,Production

Originator

Akineton HCl,Knoll,US,1959

Uses

amoebicide

Definition

ChEBI: N-Propylpiperidine in which the methyl hydrogens are substituted by hydroxy, phenyl, and 5-norbornen-2-yl groups. A muscarinic antagonist affecting both the central and peripheral nervous systems, it is used in the treatment of all form of Parkinson's disease.

Manufacturing Process

65 grams of 3-piperidino-1-phenyl propanone-1 of the summary formula C14H29ON, produced according to Mannich's reaction by reacting acetophenone with formaldehyde and piperidine hydrochloride are dissolved in 300 cc of benzene. The resulting solution is added to an organo-magnesium solution prepared from 96 grams of [δ5-bicyclo-(2,2,1)-heptenyl-2]-chloride (also known as 5-chloro-2-norbomene) 18.5 grams of magnesium shavings, and 300 cc of ether.
The reaction mixture is boiled for half an hour under reflux. Thereafter the ether is removed by distillation, until the inside temperature reaches 65°- 70°C. The resulting benzene solution is added to 95 cc concentrated hydrochloric acid containing ice for further processing. Thereby, 3-piperidino- 1-phenyl-1-[δ5-bicyclo-(2,2,1)-heptenyl-2]-propanol-1 of the summary formula C21H29ON is obtained. The compound melts at 101°C and its chlorohydrate has a melting point of about 238°C. The compound is difficultly soluble in water, slightly soluble in ethanol, and readily soluble in methanol.

brand name

Akineton (Abbott).

Therapeutic Function

Antiparkinsonian

General Description

Biperiden,α-5-norbornen-2-yl- -phenyl-1-piperidinepropanol (Akineton), introduced in 1959,has a relatively weak visceral anticholinergic, but a strongnicotinolytic, action in terms of its ability to block nicotineinducedconvulsions. Therefore, its neurotropic action israther low on intestinal musculature and blood vessels. It hasa relatively strong musculotropic action, which is aboutequal to that of papaverine, in comparison with most syntheticanticholinergic drugs. Its action on the eye, althoughmydriatic, is much lower than that of atropine. These weakanticholinergic effects add to its usefulness in Parkinson syndromeby minimizing side effects.

Clinical Use

Biperiden is used in all types of Parkinson disease (postencephalitic,idiopathic, arteriosclerotic) and helps toeliminate akinesia, rigidity, and tremor. It is also usedin drug-induced extrapyramidal disorders to eliminatesymptoms and permit continued use of tranquilizers.Biperiden is also of value in spastic disorders not related toparkinsonism, such as multiple sclerosis, spinal cord injury,and cerebral palsy. It is contraindicated in all formsof epilepsy.

Safety Profile

Poison by ingestion,subcutaneous, intraperitoneal, and intravenous routes.When heated to decomposition, it emits toxic fumes ofNOx.

Synthesis

Biperiden, 1-(5-norbornen-2-yl)-1-phenyl-3-piperidinopropan-1-ol (10.2.4), is also synthesized according to the method of making trihexyphenidyl, except by reacting 2-(1-piperidino)propiophenone (10.2.1) with 5-norbornen-2-ylmagnesiumbromide [33,34].

Bipariden Preparation Products And Raw materials

Raw materials

Piperidine hydrochloride Double ring CYCLOHEPTENE Propiophenone 1,3-Cyclopentadiene

Magnesium Hydrochloric acid Acetophenone Formaldehyde

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Preparation Products

Bipariden Suppliers

Global( 93)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei XinRunde Chemical Co., Ltd.	+8615102730682	bruce@xrdchem.cn	CHINA	566	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29220	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9339	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58

Supplier	Advantage
Hubei XinRunde Chemical Co., Ltd.	55
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
Baoji Guokang Bio-Technology Co., Ltd.	58
Zhejiang J&C Biological Technology Co.,Limited	58

View Lastest Price from Bipariden manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-07-27	Bipariden USP/EP/BP 514-65-8	US $1.10 / g	1g	99.9%	100 Tons min	Dideu Industries Group Limited
2021-07-13	Bipariden 514-65-8	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-09	Bipariden 514-65-8	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

Bipariden USP/EP/BP
514-65-8
US $1.10 / g
99.9%
Dideu Industries Group Limited

Bipariden
514-65-8
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Bipariden
514-65-8
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

514-65-8(Bipariden)Related Search:

Sildenafil Tamsulosin Entacapone Haloperidol 2,2,6,6-Tetramethyl-4-piperidinol

DROPERIDOL Dicyclopentadiene Triacetonediamine Diphenoxylate Biperiden hydrochloride

1-Piperidinepropanol CYCLOHEPTENE 5-Norbornene-2-methanol BIPERIDEN LACTATE cycrimine

Bipariden Biperiden

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alpha-(bicyclo(2.2.1)hept-5-en-2-yl)-alpha-phenyl-1-piperidinopropanol alpha-5-norbornen-2-yl-alpha-phenyl-1-piperidinepropano alpha-5-Norbornen-2-yl-alpha-phenyl-1-piperidinepropanol alpha-bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl-1-piperidinepropano alpha-phenyl-alpha-(2-piperidinoethyl)-5-norbornene-2-methano Beperiden -Bicyclo[2,2,1]hept-5-en-2yl-phenyl-1-piperidinepropanol Bicyclo[2.2.1]hept-5-ene-2-methanol, alpha-phenyl-alpha-[2-(1-piperidinyl)ethyl]- biperiden Biperidine KL 373 BIPERIDEN (200 MG) 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidyl)propan-1-ol 1-Bicyclo[2.2.1]hept-5-en-2-yl-1-phenyl-3-(1-piperidinyl)-1-propanol 1-Bicycloheptenyl-1-phenyl-3-piperidino-propanol-1 1-Piperidinepropanol, alpha-5-norbornen-2-yl-alpha-phenyl- 1-Piperidinepropanol, alpha-bicyclo[2.2.1]hept-5-en-2-yl-alpha-phenyl- 3-Piperidino-1-phenyl-1-bicyclo- 3-Piperidino-1-phenyl-1-bicyclo(2.2.1)hepten-(5)-yl-propanol-(1) 3-Piperidino-1-phenyl-1-bicycloheptenyl-1-propanol bipariden -5-Norbornen-2-yl-phenyl-1-piperidinepropanol 5-Norbornene-2-methanol, alpha-phenyl-alpha-(2-piperidinoethyl)- a-bicyclo[2.2.1]hept-5-en-2yl-a-phenyl-1-piperidinepropanol Akineton Akinophyl alpha-(Bicyclo(2.2.1)hept-5-en-2-yl)-alpha-phenyl-1-piperidino propanol kl373 1-phenyl-3-piperidino-1-(8,9,10-trinorborn-5-en-2-yl)propan-1-ol BiperidenHcl 1-Piperidinepropanol, a-5-norbornen-2-yl-a-phenyl- (6CI, 7CI, 8CI) 1-Piperidinepropanol, a-bicyclo[2.2.1]hept-5-en-2-yl-a-phenyl- α-(Bicyclo[2.2.1]hept-5-en-2-yl)-α-phenyl-1-piperidinopropanol α-(Bicyclo[2.2.1]hept-5-en-2-yl)-α-phenyl-1-piperidine-1-propanol Biperiden, USP Biperiden Hydrochloride USP Biperiden (Mixture of diastereomers) Bibristan 1-Piperidinepropanol, α-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl- Bipariden USP/EP/BP Alpha-5-Norbornene-2-yl-alphaphentl-1-piperidinepropanol (Biperiden base) Biperiden Hcl -USP/ EP/IP/JP Biperiden (1072001) 1-(Bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol Bipariden Impurity 514-65-8 C21H29NO