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3-Chloro-4-fluoroaniline

3-Chloro-4-fluoroaniline structure

CAS No.: 367-21-5

Chemical Name:: 3-Chloro-4-fluoroaniline

Synonyms: 3-CHLORO-4-FLUORO-PHENYLAMINE;3-CHLORO-4-FLUOROBENZENAMINE;NSC 10290;3-Chloro-4-flu;AKOS BBS-00003577;Chloro-4-fluoroanil;Fluorochloroaniline;Gefitinib IMpurity V;3-Chloro-4-fluoroani;Gefitinib Impurity K

CBNumber:: CB4182681

Molecular Formula:: C6H5ClFN

Molecular Weight:: 145.56

MDL Number:: MFCD00007767

MOL File:: 367-21-5.mol

MSDS File:: SDS

Last updated:2024-04-24 17:21:45

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3-Chloro-4-fluoroaniline Properties

Melting point	42-44 °C (lit.)
Boiling point	227-228 °C (lit.)
Density	1,226 g/cm³
vapor pressure	0.01 hPa (20 °C)
refractive index	1,54-1,542
Flash point	>230 °F
storage temp.	Store below +30°C.
solubility	10g/l
pka	3.60±0.10(Predicted)
form	Crystalline Solid
color	Beige to brown
PH	7 (10g/l, H2O, 20℃)
Water Solubility	10 g/L (20 ºC)
BRN	1562786
Stability	Stable. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides, chloroformates. May be air-sensitive.
InChIKey	YSEMCVGMNUUNRK-UHFFFAOYSA-N
CAS DataBase Reference	367-21-5(CAS DataBase Reference)
FDA UNII	7L63CC70UQ
EPA Substance Registry System	3-Chloro-4-fluoroaniline (367-21-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08

Signal word

Danger

Hazard statements

H301+H311+H331-H373

Precautionary statements

P260-P280-P301+P310-P302+P352+P312-P304+P340+P311-P314

Hazard Codes

T,Xi,Xn

Risk Statements

23/24/25-33-36/37/38-20/21/22

Safety Statements

36/37/39-45-26

RIDADR

UN 2811 6.1/PG 2

WGK Germany

9-23

Hazard Note

Irritant/Toxic

TSCA

HazardClass

TOXIC

HazardClass

6.1

PackingGroup

III

HS Code

29214210

Toxicity

LD50 orally in Rabbit: 506 mg/kg

NFPA 704

	0
2		0

3-Chloro-4-fluoroaniline price More Price(45)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	228583	3-Chloro-4-fluoroaniline 98%	367-21-5	25g	$26	2024-03-01	Buy
Sigma-Aldrich	8.18752	3-Chloro-4-fluoroaniline for synthesis	367-21-5	25g	$91.6	2024-03-01	Buy
Sigma-Aldrich	228583	3-Chloro-4-fluoroaniline 98%	367-21-5	100g	$64.2	2024-03-01	Buy
Sigma-Aldrich	8.18752	3-Chloro-4-fluoroaniline for synthesis	367-21-5	100g	$275	2023-01-07	Buy
TCI Chemical	C1024	3-Chloro-4-fluoroaniline >98.0%(GC)	367-21-5	25g	$16	2024-03-01	Buy

Product number	Packaging	Price	Buy
228583	25g	$26	Buy
8.18752	25g	$91.6	Buy
228583	100g	$64.2	Buy
8.18752	100g	$275	Buy
C1024	25g	$16	Buy

3-Chloro-4-fluoroaniline Chemical Properties,Uses,Production

Chemical Properties

dark purple to black solid

Uses

4-Fluoro-3-chloroaniline, is an organic Fluorinated building block used for the synthesis of pharmaceutical and biologically active compounds such as, novel 6-Fluorobenzothiazole-substituted pyrazole analogues, having antiinflammatory activity.

General Description

The exposure of workers to 3-chloro-4-fluoroaniline (CFA) was monitored by an HPLC method.

3-Chloro-4-fluoroaniline synthesis

Synthesis of 3-Chloro-4-fluoroaniline from 3-Chloro-4-fluoronitrobenzene

3-Chloro-4-fluoroaniline Preparation Products And Raw materials

Raw materials

Potassium fluoride Ferric chloride Iron chloride hexahydrate Dimethyl sulfoxide 1,2-Dichlorobenzene

Carbamic acid, (3-chloro-4-fluorophenyl)-, 1,1-dimethylethyl ester 3-Chloro-4-fluoronitrobenzene

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Preparation Products

Norfloxacin Ciprofloxacin hydrochloride 1,3-Dichloro-4-fluorobenzene Ciprofloxacin 2,4-Dichloro-5-fluorobenzoic acid

3-CHLORO-4-FLUOROPHENYL ISOTHIOCYANATE 3-Chloro-4-fluorobenzaldehyde N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-aminoquinazolin-4-aMine indoleaMine-2,3-dioxygenase inhibitor INCB024360 2-Bromo-5-chloro-4-fluoroaniline

N-(3-chloro-4-fluorophenyl)-2-hydroxybenzamide 6-Amino-4-(3-chloro-4-fluoroanilino)quinazoline (3-Chloro-4-fluorophenyl)ethylamine Benzenemethanamine, N-(3-chloro-4-fluorophenyl)-3,4-dimethoxy-

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3-Chloro-4-fluoroaniline Suppliers

Global( 611)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Aceschem Inc.	+1-817863-6948 +1-（817）863-6948	sales@aceschem.com	United States	19639	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12471	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	18232	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	+8617702722807	admin@hbouhuang.com	China	3001	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	811	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1807	55
Fluoropharm Co., Ltd.	+86-0571-85586753; +8613336034509	sales@fluoropharm.com	China	1377	60

Supplier	Advantage
Aceschem Inc.	58
Hebei Mojin Biotechnology Co., Ltd	58
Anhui Ruihan Technology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Hi-Tech Chemistry Corp	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
Fluoropharm Co., Ltd.	60

View Lastest Price from 3-Chloro-4-fluoroaniline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-24	3-Chloro-4-fluoroaniline 367-21-5	US $50.00 / kg	1kg	99.10%	50000kg	Ouhuang Engineering Materials (Hubei) Co., Ltd
2024-01-23	3-Chloro-4-fluoroaniline 367-21-5	US $9.00-0.90 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2023-09-07	3-Chloro-4-fluoroaniline 367-21-5	US $30.00 / kg	1kg	99%	1000t/year	Anhui Ruihan Technology Co., Ltd

3-Chloro-4-fluoroaniline
367-21-5
US $50.00 / kg
99.10%
Ouhuang Engineering Materials (Hubei) Co., Ltd

3-Chloro-4-fluoroaniline
367-21-5
US $9.00-0.90 / KG
99%
Henan Fengda Chemical Co., Ltd

3-Chloro-4-fluoroaniline
367-21-5
US $30.00 / kg
99%
Anhui Ruihan Technology Co., Ltd

3-Chloro-4-fluoroaniline Spectrum

3-Chloro-4-fluoroaniline(367-21-5)MS 3-Chloro-4-fluoroaniline(367-21-5)¹HNMR 3-Chloro-4-fluoroaniline(367-21-5)¹³CNMR 3-Chloro-4-fluoroaniline(367-21-5)IR1

367-21-5(3-Chloro-4-fluoroaniline)Related Search:

4-Chloroaniline 2-Chloroaniline 2-Fluoroaniline 3-Aminobenzotrifluoride 4-(Trifluoromethoxy)aniline

3-Fluoroaniline 3-Chloroaniline Chlorpropham 4-Fluoroaniline Epichlorohydrin

4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol 3-chloro-4-nitrophenol 3-(3-morpholinylpropoxy)-4-methoxybenzonitrile Benzaldehyde, 2-amino-4-methoxy-5-[3-(4-morpholinyl)propoxy]- O-Desmethyl Gefitinib

3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate 4-Defluoro-4-hydroxy Gefitinib Gefitinib Impurity 14

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3－chloro-4-fluoroanilinc 3-CHLORO-4-FLUOROANILINENORFLOXACIN 3-CHLORO-4-FLUOROANILINE pure 3-/4-CHLOROFLUOROANILINE Benzenamine, 3-chloro-4-fluoro- 3-Chloro-4-fluoroaniline 98% Chloro-4-fluoroanil Gefitinib IMpurity V 3-Chloro-4-flu 3-Chloro-4-fluoroaniline,98% 3-Chlor-4-fluoranilin 3-chloro-4-fluoro-benzenamin Fluorochloroaniline 3-CHLORO-4-FLUOROANILINE AKOS BBS-00003577 LABOTEST-BB LTBB000779 4-Fluoro-3-chloroaniline 3-CHLORO-4-FLUOROANILINE OEKANAL, 250 MG 3-Chloro-4-Fluoroaniline99% 3-CHLORO-4-FLUOROANILINE A 3-CHLORO-4-FLUOROANILINE B para-fluoro-Meta-chloroaniline M-Chloro-p-fluoro-aniline NSC 10290 3-CHLORO-4-FLUOROANILINE, 99.5+% 3-Chloro-4-fluoroanaline 3-Chloro-4-fluoroanaline 1g [367-21-5] 3-Chloro-4-fluoroani Gefitinib Impurity K 3-Chloro-4-fluoroaniline > 3-chloro-4-fluoraniline 3-Chloro-4-fluoroaniline(Chunks or pellets) 3-Chloro-4-fluoroaniline ISO 9001：2015 REACH 3-CHLORO-4-FLUOROBENZENAMINE 3-CHLORO-4-FLUORO-PHENYLAMINE Afatinib Impurity 167 367-21-5 Nitrogen Compounds Organic Building Blocks C2 to C6 Building Blocks Amines Furans ,Coumarins Anilines, Aromatic Amines and Nitro Compounds Aniline series Fluorobenzene API Intermediate C2 to C6 Nitrogen Compounds ChloroChemical Class FluoroMore...Close... Alpha Sort Amines Analytical Standards AromaticsChemical Class AromaticsVolatiles/ Semivolatiles C CAlphabetic