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Cortisone acetate

Cortisone acetate
Cortisone acetate structure
CAS No.
50-04-4
Chemical Name:
Cortisone acetate
Synonyms
artriona;cortelan;cortisyl;ricortex;NSC 49420;cortistab;biocortacetate;cortoneacetate;irisoneacetate;cortogenacetate
CBNumber:
CB9277612
Molecular Formula:
C23H30O6
Formula Weight:
402.48
MOL File:
50-04-4.mol

Cortisone acetate Properties

Melting point:
237-240 °C(lit.)
alpha 
D25 +164° (c = 0.5 in acetone); D25 +208 to +217° (dioxane)
refractive index 
212 ° (C=1, MeOH)
storage temp. 
2-8°C
solubility 
Practically insoluble in water, freely soluble in methylene chloride, soluble in dioxan, sparingly soluble in acetone, slightly soluble in ethanol (96 per cent) and in methanol.
form 
neat
Merck 
14,2539
BRN 
2067543
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
50-04-4(CAS DataBase Reference)
EPA Substance Registry System
Pregn-4-ene-3,11, 20-trione, 21-(acetyloxy)-17-hydroxy- (50-04-4)

SAFETY

Safety Statements  22-36/37-24/25
WGK Germany  3
RTECS  GM9140000
HS Code  32041200
HS Code  32041200

Cortisone acetate price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C2800000 Cortisone acetate European Pharmacopoeia (EP) Reference Standard 50-04-4 c2800000 $179 2018-11-23 Buy
Sigma-Aldrich BP585 Cortisone acetate British Pharmacopoeia (BP) Reference Standard 50-04-4 bp585 $185 2018-11-23 Buy
Cayman Chemical 23798 Cortisone Acetate ≥98% 50-04-4 5g $49 2018-11-19 Buy
Cayman Chemical 23798 Cortisone Acetate ≥98% 50-04-4 10g $93 2018-11-19 Buy
Sigma-Aldrich PHR1923 Cortisone Acetate Pharmaceutical Secondary Standard; Certified Reference Material 50-04-4 300mg $143 2018-11-23 Buy

Cortisone acetate Chemical Properties,Uses,Production

Chemical Properties

solid

Uses

Cortisone Acetate is a glucocorticoid. Cortisone Acetate is an antiinflammatory agent. Cortisone Acetate is bioavailable and readily converted to the therapeutically active form, Hydrocotisone (H71461 5).

General Description

Cortisone acetate, 21-(acetyloxy)-17-hydroxypregn-4-ene-3,11,20-trione, is the 21-acetate of naturally occurring cortisone with good systemicanti-inflammatory activity and low-to-moderate salt-retentionactivity after its in vivo conversion to hydrocortisoneacetate. This conversion is mediated by 11β-hydroxysteroiddehydrogenase. It is used for the entire spectrum of uses discussedpreviously under the heading, “Therapeutic Uses ofAdrenal Cortex Hormones”—collagen diseases, Addisondisease, severe shock, allergic conditions, chronic lymphocyticleukemia, and many other indications. Cortisone acetateis relatively ineffective topically, mainly because itmust be reduced in vivo to hydrocortisone. Its plasma halflifeis only about 30 minutes, compared with 90 minutes to3 hours for hydrocortisone.

Purification Methods

Crystallise -1cortisone-21-acetate from acetone or CHCl3. The UV has 15,800 M-1cm at 238nm in dioxane. [Sarett J Biol Chem 162 601 1946, Beilstein 8 III 4058, 5 IV 3481.]

Cortisone acetate Preparation Products And Raw materials

Raw materials

Preparation Products


Cortisone acetate Suppliers

Global( 212)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21954 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
+86-571-56059825 fandachem@gmail.com CHINA 2561 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24001 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 4669 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40277 62

Cortisone acetate Spectrum


50-04-4(Cortisone acetate)Related Search:


  • 11,20-trione,17,21-dihydroxy-pregn-4-ene-21-acetate
  • 11-dehydro-17-hydroxycorticosterone-21-acetate
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  • KENDALL'S COMPOUND 'E' ACETATE
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  • DELTA4-PREGNEN-17ALPHA-21-DIOL-3, 11, 20-TRIONE-21-ACETATE
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  • 4-PREGNEN-17ALPHA,21-DIOL-3,11,20-TRIONE ACETATE
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  • 17,21-DIHYDROXYPREGN-4-ENE-3,11,20-TRIONE 21 ACETATE
  • 21-acetoxypregnen-17a-ol-3,11,20-trione
  • 21-Acetoxypregnen-17alpha-ol-3,11,20-trione
  • Cortisoneacetate,99%
  • Cortison Acetate
  • CORTISONE ACETATE CRYSTALLINE
  • CORTISONE-21-ACETATE, PH EUR
  • Pregn-4-ene-3,11,20-trione, 21-(acetyloxy)-17-hydroxy-
  • CORTISONEACETATE,MICRONIZED,USP
  • CORTISONEACETATE,POWDER,USP
  • 21-Acetoxy-17-hydroxypregn-4-ene-3,11,20-trione
  • 21-Acetoxy-17α-hydroxy-3,11,20-triketopregnene-4
  • 21-Acetoxy-17α-hydroxypregn-4-ene-3,11,20-trione
  • 4-Pregnene-17a,21-diol-3,11,20-trione 21-acetate
  • Cortisone, 21-acetate (8CI)
  • Cortisone acetate (Cortisone 21-acetate)
  • 20-trione,21-(acetyloxy)-17-hydroxy-pregn-4-ene-11
  • 21-(acetyloxy)-17-hydroxypregn-4-ene-3,11,20-trione
  • 21-acetoxy-17,alpha-hydroxy-3,11,20-triketopregnene-4
  • 21-acetoxy-17,alpha-hydroxypregn-4-ene-3,11,20-trione
  • acetatecortisone
  • artriona
  • biocortacetate
  • compoundeacetate
  • cortelan
  • cortisonemonoacetate
  • cortistab
  • cortisyl
  • cortogenacetate
  • cortoneacetate
  • irisoneacetate
  • ricortex
  • Pregn-4-ene-3,11,20-trione, 17,21-dihydroxy-, 21-acetate (7CI)
  • 17α,21-Dihydroxy-4-pregnene-3,11,20-trione 21-acetate, 21-Acetoxy-4-pregnen-17α-ol-3,11,20-trione, 4-Pregnene-17α,21-diol-3,11,20-trione 21-acetate
  • 17α,21-Dihydroxy-4-pregnene-3,11,20-trione 21-acetate, 21-Acetoxy-4-pregnen-17α-ol-3,11,20-trione, 4-Pregnene-17α,21-diol-3,11,20-trione 21-acetate, Cortisoni acetas
  • 17,21-dihydroxypregn-4-ene-3,11,20-trione acetat
  • Cortisone Acetate (150 mg)
  • Cortison phosphate
  • Cortone 21-Acetate
  • IMp. A (EP): Hydrocortisone Acetate
  • CORTISONE ACETATE ONISED
  • 2-((8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-diMethyl-3,11-dioxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
  • Cortisone Acetate, 99.0%(LC)
  • 17α,21-Dihydroxy-4-pregnene-3,11,20-trione 21-acetate
  • Cortisyl Artriona
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