4-Phenylbutyric acid
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4-Phenylbutyric acid 속성
- 녹는점
- 49-51 °C(lit.)
- 끓는 점
- 165 °C10 mm Hg(lit.)
- 밀도
- 1.0326 (rough estimate)
- 굴절률
- 1.5405 (estimate)
- 인화점
- >230 °F
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- 5.3g/L
- 물리적 상태
- 결정성 분말
- 산도 계수 (pKa)
- 4.76(at 25℃)
- 색상
- 흰색에서 약간 노란색
- 수용성
- 40°C에서 5.3g/L
- BRN
- 638180
- InChIKey
- OBKXEAXTFZPCHS-UHFFFAOYSA-N
- LogP
- 2.420
- CAS 데이터베이스
- 1821-12-1(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38 | ||
| 안전지침서 | 22-24/25-36-26 | ||
| WGK 독일 | 3 | ||
| 위험 참고 사항 | Irritant | ||
| TSCA | Yes | ||
| HS 번호 | 29163900 |
4-Phenylbutyric acid C화학적 특성, 용도, 생산
화학적 성질
4-Phenylbutyric acid is white to slightly yellowish crystalline powder. It is slightly soluble in chloroform and methanol. Its solubility in water is 5.3 g/l (at 40 °C).제조 방법
4-phenylbutyric acid is obtained by the reaction of benzene with butyrolactone in the presence of aluminum chloride, followed by neutralization with base.Synthesis of 4-phenylbutyric acid
주요 응용
4-Phenylbutyric acid (4-PBA) is used in the treatment of urea cycle disorders under the trade name Buphenyl. 4-PBA has been used as a selective inhibitor of endoplasmic reticulum stress (ERS).4-Phenylbutyric acid is used as organic intermediates. It can also be used as a reactant in the synthesis of:
1-Tetralone using Lewis acid catalyst.
4,N-diphenylbutyramide.
정의
4-Phenylbutyric acid is a monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apopto is in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.일반 설명
4-Phenylbutyric acid (4-PBA) is a small-molecular-weight fatty acid with a terminal aromatic group, and its sodium salt (sodium 4-phenyl butyrate) has been used for the treatment of urea cycle disorders. This molecule is also used for the treatment of sickle cell diseases and thalassemia owing to its ability to activate β-globin transcription. Moreover, 4-PBA is employed as an orally bioavailable agent for the treatment of spinal muscular atrophy (SMA) and tumors.Neuroprotective Effects of 4-phenylbutyric Acid and Its Derivatives: Possible Therapeutics for Neurodegenerative Diseases
Purification Methods
Crystallise the acid from pet ether (b 40-60o). [Beilstein 9 IV 1811.]4-Phenylbutyric acid 준비 용품 및 원자재
원자재
준비 용품
METHYL 3-(4-CHLOROSULFONYL)PHENYLPROPIONATE
METHYL 4-PHENYLBUTYRATE
Imidapril
클로르암부실
1-Tetralone
ETHYL 4-PHENYLBUTYRATE
METHYL 4-(4-(BIS(2-CHLOROETHYL)AMINO)PHENYL)BUTYRATE
GAMMA-PHENYL-GAMMA-BUTYROLACTONE
4-(P-IODOPHENYL)BUTYRIC ACID
4-Phenylbutyryl chloride
7-Nitro-1-tetralone
1-Bromo-4-phenylbutane
4-Phenylbutyric acid 공급 업체
글로벌( 467)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 |
stella@zetchem.com | China | 2141 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5993 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 7845 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
4-Phenylbutyric acid 관련 검색:
이소낙산 부탄 산 감마-아미노-N-부티르 산 3-인돌부틸산 클로르암부실 α-브로모부틸산에틸 1-나프탈렌붕산
Hydrocortisone-17-butyrate
4-Phenylbutanol
(E)-1-HEXENE-1,2-DIBORONIC ACID BIS(PINACOL) ESTER
N-TETRADECYLBORONIC ACID
1-Nonaneboronic acid
CYCLOPENTEN-1-YLBORONIC ACID
1-Octylboronic acid
FERROCENEBORONIC ACID
1-Hexaneboronic acid
1-CIS-1,2-BIS(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)HEPTENE
4-(4-Aminophenyl)butyric acid