Pramipexole Impurity 4
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Pramipexole Impurity 4 속성
- 녹는점
- 288-290°C
- 저장 조건
- 2-8°C
- 용해도
- H2O: >20mg/mL
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- InChIKey
- QMNWXHSYPXQFSK-KLXURFKVSA-N
- CAS 데이터베이스
- 104632-25-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
WGK 독일 | 3 |
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Pramipexole Impurity 4 C화학적 특성, 용도, 생산
개요
Mirapex, an non ergot derivative, was launched in the US for treatment of Parkinson's disease. It can be prepared by two related routes, 5 steps and 3 steps, both involving an optical resolution with L-(+)-tartaric acid to afford the (S)-isomer. Mechanistically, it is a presynaptic dopamine D2 autoreceptor agonist which also activates D3-receptors. It is well absorbed from the GI and excreted in the urine essentially unchanged with a half-life of 8-12 hr. Mirapex had favorable effects on the symptoms without levodopa for patients with advanced PD and allowed a 27% reduction in use of levodopa in combination therapy. It had an adverse events profile similar to other dopamine agonists and in advanced patients reduced the mean "on-off" hr/day from 6 to 4. It was safe but not efficacious in all patients.화학적 성질
White Crystalline Powder정의
ChEBI: A hydrochloride that is the anhydrous dihydrochloride salt of pramipexole.일반 설명
Pramipexole dihydrochloride,(S)-2-amino-6-propylamino-dihydrochloride(Mirapex), is a white to off-white powder soluble in water,slightly soluble in methanol and ethanol, and practically insolublein dichloromethane. Following oral administration,pramipexole is readily absorbed. Pharmacokinetic propertiesdiffer between men and women, with area under the curve(AUC) for each dose level being 35% to 43% greater inwomen, mainly because of a 24% to 27% lower oral clearance.The drug undergoes minimal hepatic biotransformationand is excreted virtually unchanged in the urine by the renaltubular secretion. Pramipexole interacts with drugs excretedby renal tubular secretion (H2-antagonists, diuretics, verapamil,quinidine, quinine), which leads to a decreased clearanceof pramipexole.44,45 Pramipexole is indicated fortreatment of the signs and symptoms of idiopathic PD, aloneor in combination with levodopa. It is also indicated for symptomatictreatment of moderate to severe idiopathic restlesslegs syndrome (RLS).Pramipexole Impurity 4 준비 용품 및 원자재
원자재
티오요소
아세트산(빙초산)
염산
무수프탈산
브롬화수소
4-아미노사이클로헥산올염산염
중크롬산 칼륨
나트륨 붕소수화물
하이드라진, 모노수화물
N,N-다이아이소프로필에틸아민
프로피온알데히드
준비 용품
Pramipexole Impurity 4 공급 업체
글로벌( 303)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Jinan Million Pharmaceutical Co., Ltd | 0531-68659554 +8613031714605 |
info@millionpharm.com | China | 205 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
Chembon Pharmaceutical Co., Ltd. | +86-28-8425-2981 |
CHINA | 724 | 55 | |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Jinan Jianfeng Chemical Co., Ltd | +8615562555968 |
info@pharmachemm.com | China | 247 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
Pramipexole Impurity 4 관련 검색:
염산디펜히드라민 트리스(하이드록시메틸)아미노메탄 벤조티아졸 6-아미노 카프로산 글리신 D-글루코사민 디벤조티아질 디설파이드 2-메르캅토벤조티아졸
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