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L-アスパラギン酸

L-アスパラギン酸 化学構造式
56-84-8
CAS番号.
56-84-8
化学名:
L-アスパラギン酸
别名:
L-アスパラギン酸;L-アミノこはく酸;(S)-アミノブタン二酸;アスパラギン酸;(+)-L-アスパラギン酸;(S)-アスパラギン酸;(S)-2-アミノこはく酸;(S)-2-アミノブタン二酸;(+)-アスパラギン酸;L-アスパルト酸;Lアスパラギン酸;(S)-アミノこはく酸;L‐アスパラギン酸;L‐アスパラギン酸 CRM6027‐A;アスパラギン酸, L-;L-アスパラギン酸標準品;アスパラギン酸, resDarch grade;L-アスパラギン酸 (JP17)
英語化学名:
L-Aspartic acid
英語别名:
ASP;L-ASP;H-ASP-OH;L-Asp-OH;FEMA 3656;ASPARTATE;H-L-ASP-OH;Aspatofort;L-ASPARGINE;ASPARTIC(L-)
CBNumber:
CB3141599
化学式:
C4H7NO4
分子量:
133.1
MOL File:
56-84-8.mol

L-アスパラギン酸 物理性質

融点 :
>300 °C (dec.)(lit.)
比旋光度 :
25 º (c=8, 6N HCl)
沸点 :
245.59°C (rough estimate)
比重(密度) :
1.66
屈折率 :
1.4540 (estimate)
FEMA :
3656 | L-ASPARTIC ACID
貯蔵温度 :
Store at RT.
溶解性:
H2O: 5 mg/mL
外見 :
powder
酸解離定数(Pka):
1.99(at 25℃)
色:
White
PH:
2.5-3.5 (4g/l, H2O, 20℃)
光学活性 (optical activity):
[α]20/D +24.7±1°, c = 5% in 5 M HCl
水溶解度 :
5 g/L (25 ºC)
極大吸収波長 (λmax):
λ: 260 nm Amax: 0.20
λ: 280 nm Amax: 0.10
Merck :
14,840
JECFA Number:
1429
BRN :
1723530
安定性::
Stable. Combustible. Incompatible with strong oxidising agents.
InChIKey:
CKLJMWTZIZZHCS-REOHCLBHSA-N
CAS データベース:
56-84-8(CAS DataBase Reference)
NISTの化学物質情報:
Aspartic acid(56-84-8)
EPAの化学物質情報:
Aspartic acid (56-84-8)

安全性情報

主な危険性  Xi,Xn
Rフレーズ  36-36/37/38-20/21/22
Sフレーズ  26-24/25-22-36
WGK Germany  2
RTECS 番号 CI9098500
10
TSCA  Yes
国連危険物分類  IRRITANT
HSコード  29224995
有毒物質データの 56-84-8(Hazardous Substances Data)
毒性 LD50 intraperitoneal in mouse: 6gm/kg
化審法 (2)-1305 届出不要化学物質

L-アスパラギン酸 価格 もっと(61)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00011051 アスパラギン酸, L-
Aspartic Acid, L-
56-84-8 100mg ¥13400 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00011051 アスパラギン酸, L-
Aspartic Acid, L-
56-84-8 5g ¥33300 2018-12-26 購入
東京化成工業 A0546 L-アスパラギン酸 >99.0%(T)
L-Aspartic Acid >99.0%(T)
56-84-8 500g ¥5900 2018-12-04 購入
東京化成工業 A0546 L-アスパラギン酸 >99.0%(T)
L-Aspartic Acid >99.0%(T)
56-84-8 25g ¥1900 2018-12-04 購入
関東化学株式会社(KANTO) 01453-30 L‐アスパラギン酸 >99.0%(T)
L‐Aspartic acid >99.0%(T)
56-84-8 25g ¥1900 2018-12-13 購入

L-アスパラギン酸 MSDS


L-Aminosuccinic acid

L-アスパラギン酸 化学特性,用途語,生産方法

外観

白色の結晶性粉末

定義

本品は、次の化学式で表されるアミノ酸である。

溶解性

水に溶けにくく、エタノールにほとんど溶けない。

化粧品の成分用途

ヘアコンディショニング剤、皮膚コンディショニング剤

効能

アミノ酸補充薬

特長

塩酸酸性溶液は右旋性、塩基性溶液は左旋性を示す。

使用上の注意

不活性ガス封入

説明

L-Aspartic acid is the L-form of the aspartic acid. It is one of the 20 amino acids that used in the protein synthesis. It is the non-essential amino acids for humans as it can be synthesized in vivo. It is important in the synthesis of other amino acids and some nucleotides, and is a metabolite in the citric acid and urea cycles. In animals, it may be used as a neurotransmitter. It can be chemically synthesize from the diethyl sodium phthalimidomalonate. Currently, almost all the aspartic acids are manufactured in China. Its application include being used as low calorie sweetener (as the part of the aspartame), scale and corrosion inhibitor, and in resins. One of its growing applications is for the manufacturing of biodegradable superabsorbent polymer, polyaspartic acid. It can also be used in fertilizer industry to improve water retention and nitrogen uptake.

化学的特性

Colorless crystals. Soluble in water; insoluble in alcohol and ether. Optically active. dl-aspartic acid.

化学的特性

Aspartic acid (abbreviated as Asp or D) is an α-amino acid with the chemical formula HOOCCH(NH2 )CH2COOH. The carboxylate anion, salt, or ester of aspartic acid is known as aspartate. The Lisomer of aspartate is one of the 20 proteinogenic amino acids, i.e., the building blocks of proteins. Its codons are GAU and GAC. Aspartic acid is, together with glutamic acid, classified as an acidic amino acid with a pKa of 3.9, however in a peptide the pKa is highly dependent on the local environment. A pKa as high as 14 is not at all uncommon. Aspartate is pervasive in biosynthesis. As with all amino acids, the presence of acid protons depends on the residue's local chemical environment and the pH of the solution.

化学的特性

Apartic acid is an aliphatic monoaminodicarboxylic acid (amino acid) and is a well-known constituent of protein. It has a slight acid taste

天然物の起源

Dietary sources
Aspartic acid is not an essential amino acid, which means that it can be synthesized from central metabolic pathway intermediates in humans. Aspartic acid is found in :
Animal sources : luncheon meats, sausage meat, wild game
Vegetable sources: sprouting seeds, oat flakes, avocado,
asparagus , young sugarcane, and molasses from sugar beets.
Chemical synthesis
Racemic aspartic acid can be synthesized from diethyl sodium phthalimido malonate, (C6H4(CO)2NC(CO2Et)2).
The major disadvantage of the above technique is that equimolar amounts of each enantiomer are made. Using biotechnology it is now possible to use immobilized enzymes to create just one type of enantiomer owing to their stereo specificity. Aspartic acid is made synthetically using ammonium fumarate and aspartase from E.coli, E.coli usually breaks down the aspartic acid as a nitrogen source but using excess amounts of ammonium fumarate a reversal of the enzyme's job is possible, and so aspartic acid is made to very high yields, 98.7 mM from 1 M.

来歴

Aspartic acid was first discovered in 1827 by Plisson, derived from asparagine, which had been isolated from asparagus juice in 1806, by boiling with a base.

使用

L-aspartic acid is used as a dietary supplement, it can be blended with minerals to make compounds like potassium aspartate, copper aspartate, manganese aspartate, magnesium aspartate, zinc aspartate and more. Increasing the absorption, and hence utilization potentials, of these minerals via the addition of aspartate induces certain health benefits. Many athletes use L-aspartic acid-based mineral supplements orally to enhance their performance capacities. Aspartic acid and glutamic acid play important roles as general acids in enzyme active centers, as well as in maintaining the solubility and ionic character of proteins. It can help promote a robust metabolism, and is sometimes used to treat fatigue and depression. Aspartic acid is used as a component of parenteral and enteral nutrition. In pharmaceutical agents aspartic acid is used as an ammoniac detoxicating agent, hepar function accelerator and fatigue refresher.

使用

l-aspartic acid is an amino acid used as a skin-conditioning agent.

定義

ChEBI: The L-enantiomer of aspartic acid.

Aroma threshold values

Detection: 300 ppb

危険性

Low toxicity.

生物活性

Endogenous NMDA receptor agonist.

安全性プロファイル

Low toxicity by intraperitoneal route. When heated to decomposition emits toxic fumes of NOx.

Chemical Synthesis

Aspartate is non - essential in mammals, being produced from oxaloacetate by transamination. It can also be generated from ornithine and citrulline in the urea cycle. In plants and microorganisms, aspartate is the precursor to several amino acids, including four that are essential for humans: methionine, threonine, isoleucine, and lysine. The conversion of aspartate to these other amino acids begins with reduction of aspartate to its "semi aldehyde," O2CCH(NH2)CH2CHO. Asparagine is derived from aspartate via trans amidation :
-O2CCH(NH2)CH2CO2 - + G C (O)NH3+ O2CCH(NH2)CH2CONH3+ + GC(O)O
(where GC(O)NH2 and GC(O)OH are glutamine and glutamic acid, respectively).

Chemical Synthesis

Enzymatically, aspartic acid is reversibly synthesized by a transamination reaction between oxaloacetic acid and glutamic acid in the presence of pyridoxal phosphate.

Forms and nomenclature

There are two forms or enantiomers of aspartic acid. The name "aspartic acid" can refer to either enantiomer or a mixture of two. Of these two forms, only one, "L - aspartic acid", is directly incorporated into proteins. The biological roles of its counterpart, "Daspartic acid" are more limited. Where enzymatic synthesis will produce one or the other, most chemical syntheses will produce both forms, "DL-aspartic acid," known as a racemic mixture.

Other biochemical roles

Aspartate is also a metabolite in the urea cycle and participates in gluconeogenesis. It carries reducing equivalents in the malateaspartate shuttle, which utilizes the ready inter conversion of aspartate and oxaloacetate, which is the oxidized (dehydrogenated) derivative of malic acid. Aspartate donates one nitrogen atom in the biosynthesis of inosine, the precursor to the purine bases. In addition, aspartic acid acts as hydrogen acceptor in a chain of ATP synthase.

L-アスパラギン酸 上流と下流の製品情報

原材料

準備製品


L-アスパラギン酸 生産企業

Global( 531)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2995 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21686 58
Dalian Richfortune Chemicals Co., Ltd
86-411-84820922, 84821539
86-411-84821380 sales@richfortunechem.com China 360 57
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32447 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
ATK CHEMICAL COMPANY LIMITED
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Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1870 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
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56-84-8(L-アスパラギン酸)キーワード:


  • 56-84-8
  • Erlotinib-d7 HCl
  • (S)-(+)-Aminosuccinic acid (S)-Aminobutanedioic acid (S)-Aminosuccinic Acid H-Asp-OH L-Asparaginic Acid L(+)-Aspartic acid
  • L-Aspartic acid, Low metals content
  • ASP
  • ASPARTIC(L-)
  • ASPARTIC ACID
  • ASPARTIC ACID, L-
  • H-ASP-OH
  • FEMA 3656
  • H-L-ASP-OH
  • L-ALPHA-AMINOSUCCINIC ACID
  • L-AMINOSUCCINIC ACID
  • L-ASPARAGINIC ACID
  • L-ASP
  • L-ASPARGINE
  • (+)-L-ASPARTIC ACID
  • L-(+)-ASPARTIC ACID
  • L-ASPARTIC ACID
  • L-ASPARATATE
  • L-2-AMINOBUTANEDIOIC ACID
  • ACIDUM ASPARTICUM
  • (S)-2-AMINOSUCCINIC ACID
  • (S)-(+)-AMINOSUCCINIC ACID
  • (S)-AMINOSUCCINIC ACID
  • (S)-AMINOBUTANEDIOIC ACID
  • (S)-(+)-ASPARTIC ACID
  • (2S)-Aspartic acid
  • ASPARTATE
  • Asparaginsure
  • aminobutanedioic acid
  • L-アスパラギン酸
  • L-アミノこはく酸
  • (S)-アミノブタン二酸
  • アスパラギン酸
  • (+)-L-アスパラギン酸
  • (S)-アスパラギン酸
  • (S)-2-アミノこはく酸
  • (S)-2-アミノブタン二酸
  • (+)-アスパラギン酸
  • L-アスパルト酸
  • Lアスパラギン酸
  • (S)-アミノこはく酸
  • L‐アスパラギン酸
  • L‐アスパラギン酸 CRM6027‐A
  • アスパラギン酸, L-
  • L-アスパラギン酸標準品
  • アスパラギン酸, resDarch grade
  • L-アスパラギン酸 (JP17)
  • α-アミノ酸
  • アミノ酸
  • 光学分割
  • 生化学
  • 塩基の光学分割剤
  • 有機合成化学
  • 代謝産物
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