ChemicalBook
Chinese English Japanese Germany Korea

L-아스파라긴 산

L-아스파라긴 산
L-아스파라긴 산 구조식 이미지
카스 번호:
56-84-8
한글명:
L-아스파라긴 산
동의어(한글):
L-아스파라긴산;아스파라진산;아스파틱산;아스파틱애씨드
상품명:
L-Aspartic acid
동의어(영문):
ASP;L-ASP;H-ASP-OH;L-Asp-OH;FEMA 3656;ASPARTATE;H-L-ASP-OH;Aspatofort;L-ASPARGINE;ASPARTIC(L-)
CBNumber:
CB3141599
분자식:
C4H7NO4
포뮬러 무게:
133.1
MOL 파일:
56-84-8.mol

L-아스파라긴 산 속성

녹는점
>300 °C (dec.)(lit.)
알파
25 º (c=8, 6N HCl)
끓는 점
245.59°C (rough estimate)
밀도
1.66
굴절률
1.4540 (estimate)
FEMA
3656 | L-ASPARTIC ACID
저장 조건
Store at RT.
용해도
H2O: 5 mg/mL
물리적 상태
powder
산도 계수 (pKa)
1.99(at 25℃)
색상
White
수소이온지수(pH)
2.5-3.5 (4g/l, H2O, 20℃)
optical activity
[α]20/D +24.7±1°, c = 5% in 5 M HCl
수용성
5 g/L (25 ºC)
최대 파장(λmax)
λ: 260 nm Amax: 0.20
λ: 280 nm Amax: 0.10
Merck
14,840
JECFA Number
1429
BRN
1723530
안정성
Stable. Combustible. Incompatible with strong oxidising agents.
InChIKey
CKLJMWTZIZZHCS-REOHCLBHSA-N
CAS 데이터베이스
56-84-8(CAS DataBase Reference)
NIST
Aspartic acid(56-84-8)
EPA
L-Aspartic acid(56-84-8)

안전

위험품 표기 Xi,Xn
위험 카페고리 넘버 36-36/37/38-20/21/22
안전지침서 26-24/25-22-36
WGK 독일 2
RTECS 번호 CI9098500
F 고인화성물질 10
TSCA Yes
위험 등급 IRRITANT
HS 번호 29224995
유해 물질 데이터 56-84-8(Hazardous Substances Data)

L-아스파라긴 산 MSDS


L-Aminosuccinic acid

L-아스파라긴 산 C화학적 특성, 용도, 생산

개요

L-Aspartic acid is the L-form of the aspartic acid. It is one of the 20 amino acids that used in the protein synthesis. It is the non-essential amino acids for humans as it can be synthesized in vivo. It is important in the synthesis of other amino acids and some nucleotides, and is a metabolite in the citric acid and urea cycles. In animals, it may be used as a neurotransmitter. It can be chemically synthesize from the diethyl sodium phthalimidomalonate. Currently, almost all the aspartic acids are manufactured in China. Its application include being used as low calorie sweetener (as the part of the aspartame), scale and corrosion inhibitor, and in resins. One of its growing applications is for the manufacturing of biodegradable superabsorbent polymer, polyaspartic acid. It can also be used in fertilizer industry to improve water retention and nitrogen uptake.

화학적 성질

Colorless crystals. Soluble in water; insoluble in alcohol and ether. Optically active. dl-aspartic acid.

화학적 성질

Aspartic acid (abbreviated as Asp or D) is an α-amino acid with the chemical formula HOOCCH(NH2 )CH2COOH. The carboxylate anion, salt, or ester of aspartic acid is known as aspartate. The Lisomer of aspartate is one of the 20 proteinogenic amino acids, i.e., the building blocks of proteins. Its codons are GAU and GAC. Aspartic acid is, together with glutamic acid, classified as an acidic amino acid with a pKa of 3.9, however in a peptide the pKa is highly dependent on the local environment. A pKa as high as 14 is not at all uncommon. Aspartate is pervasive in biosynthesis. As with all amino acids, the presence of acid protons depends on the residue's local chemical environment and the pH of the solution.

화학적 성질

Apartic acid is an aliphatic monoaminodicarboxylic acid (amino acid) and is a well-known constituent of protein. It has a slight acid taste

출처

Dietary sources
Aspartic acid is not an essential amino acid, which means that it can be synthesized from central metabolic pathway intermediates in humans. Aspartic acid is found in :
Animal sources : luncheon meats, sausage meat, wild game
Vegetable sources: sprouting seeds, oat flakes, avocado,
asparagus , young sugarcane, and molasses from sugar beets.
Chemical synthesis
Racemic aspartic acid can be synthesized from diethyl sodium phthalimido malonate, (C6H4(CO)2NC(CO2Et)2).
The major disadvantage of the above technique is that equimolar amounts of each enantiomer are made. Using biotechnology it is now possible to use immobilized enzymes to create just one type of enantiomer owing to their stereo specificity. Aspartic acid is made synthetically using ammonium fumarate and aspartase from E.coli, E.coli usually breaks down the aspartic acid as a nitrogen source but using excess amounts of ammonium fumarate a reversal of the enzyme's job is possible, and so aspartic acid is made to very high yields, 98.7 mM from 1 M.

역사

Aspartic acid was first discovered in 1827 by Plisson, derived from asparagine, which had been isolated from asparagus juice in 1806, by boiling with a base.

용도

L-aspartic acid is used as a dietary supplement, it can be blended with minerals to make compounds like potassium aspartate, copper aspartate, manganese aspartate, magnesium aspartate, zinc aspartate and more. Increasing the absorption, and hence utilization potentials, of these minerals via the addition of aspartate induces certain health benefits. Many athletes use L-aspartic acid-based mineral supplements orally to enhance their performance capacities. Aspartic acid and glutamic acid play important roles as general acids in enzyme active centers, as well as in maintaining the solubility and ionic character of proteins. It can help promote a robust metabolism, and is sometimes used to treat fatigue and depression. Aspartic acid is used as a component of parenteral and enteral nutrition. In pharmaceutical agents aspartic acid is used as an ammoniac detoxicating agent, hepar function accelerator and fatigue refresher.

용도

l-aspartic acid is an amino acid used as a skin-conditioning agent.

정의

ChEBI: The L-enantiomer of aspartic acid.

Aroma threshold values

Detection: 300 ppb

위험도

Low toxicity.

생물학적 활성

Endogenous NMDA receptor agonist.

Safety Profile

Low toxicity by intraperitoneal route. When heated to decomposition emits toxic fumes of NOx.

Chemical Synthesis

Enzymatically, aspartic acid is reversibly synthesized by a transamination reaction between oxaloacetic acid and glutamic acid in the presence of pyridoxal phosphate.

Chemical Synthesis

Aspartate is non - essential in mammals, being produced from oxaloacetate by transamination. It can also be generated from ornithine and citrulline in the urea cycle. In plants and microorganisms, aspartate is the precursor to several amino acids, including four that are essential for humans: methionine, threonine, isoleucine, and lysine. The conversion of aspartate to these other amino acids begins with reduction of aspartate to its "semi aldehyde," O2CCH(NH2)CH2CHO. Asparagine is derived from aspartate via trans amidation :
-O2CCH(NH2)CH2CO2 - + G C (O)NH3+ O2CCH(NH2)CH2CONH3+ + GC(O)O
(where GC(O)NH2 and GC(O)OH are glutamine and glutamic acid, respectively).

Forms and nomenclature

There are two forms or enantiomers of aspartic acid. The name "aspartic acid" can refer to either enantiomer or a mixture of two. Of these two forms, only one, "L - aspartic acid", is directly incorporated into proteins. The biological roles of its counterpart, "Daspartic acid" are more limited. Where enzymatic synthesis will produce one or the other, most chemical syntheses will produce both forms, "DL-aspartic acid," known as a racemic mixture.

Other biochemical roles

Aspartate is also a metabolite in the urea cycle and participates in gluconeogenesis. It carries reducing equivalents in the malateaspartate shuttle, which utilizes the ready inter conversion of aspartate and oxaloacetate, which is the oxidized (dehydrogenated) derivative of malic acid. Aspartate donates one nitrogen atom in the biosynthesis of inosine, the precursor to the purine bases. In addition, aspartic acid acts as hydrogen acceptor in a chain of ATP synthase.

L-아스파라긴 산 준비 용품 및 원자재

원자재

준비 용품


L-아스파라긴 산 공급 업체

글로벌( 495)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21935 58
Dalian Richfortune Chemicals Co., Ltd
86-411-84820922, 84821539
86-411-84821380 sales@richfortunechem.com China 360 57
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 495 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20676 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32452 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 661 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24196 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1815 55
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4002 58
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58

Copyright 2019 © ChemicalBook. All rights reserved