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二亜硫酸二ナトリウム

二亜硫酸二ナトリウム 化学構造式
7681-57-4
CAS番号.
7681-57-4
化学名:
二亜硫酸二ナトリウム
别名:
ピロ亜硫酸ナトリウム;メタスルファイトナトリウム;二亜硫酸ジナトリウム;二亜硫酸二ナトリウム;メタ重亜硫酸ナトリウム;二亜硫酸ナトリウム;メタ重硫酸ナトリウム;ピロ亜硫酸Na;ピロ亜硫酸ナトリウム(二亜硫酸ナトリウム);重亜硫酸二ナトリウム;二亜硫酸ナトリウム (固体);ピロ亜硫酸ナトリウム 二亜硫酸ナトリウム;メタ重亜硫酸ナトリウム PURISS. P.A.,ACS REAGENT,REAG. PH. EUR.,DRY,98-100.5%;メタ重亜硫酸ナトリウム PURISS.,MEETS ANALYTICAL SPECIFICATION OF PH. EUR.,BP,NF,FCC,E223,DRY,97-100.5%;メタ重亜硫酸ナトリウム REAGENT GRADE,97%;メタ二亜硫酸ナトリウム;メタ重亜硫酸ナトリウム, ACS;ピロ亜硫酸ナトリウム「製造専用」;ピロ亜硫酸ナトリウム( 二亜硫酸ナトリウム);メタ重亜硫酸ナトリウム, 97%
英語化学名:
Sodium metabisulfite
英語别名:
E223;fertisilo;Sodium disulphite;SodiuM pyrosulfit;Sodium pyrosulfite;Sodiummetabisufite;Sodium dissulfite ;Disodium disulphite;Sodium pyrosulphite;Sodiummetadisulfite
CBNumber:
CB9854280
化学式:
2Na.O5S2
分子量:
190.11
MOL File:
7681-57-4.mol

二亜硫酸二ナトリウム 物理性質

融点 :
150 °C
比重(密度) :
1.48
貯蔵温度 :
Store at RT.
溶解性:
540 g/L (20°C)
外見 :
Powder/Solid
比重:
1.48
色:
White to slightly yellow
PH:
3.5-5 (50g/l, H2O, 20℃)
水溶解度 :
540 g/L (20 ºC)
Sensitive :
Air & Moisture Sensitive
Merck :
14,8638
安定性::
Stable. Incompatible with strong oxidizing agents, strong acids. Contact with strong acids releases a poisonous gas. May be moisture and air sensitive.
InChIKey:
HRZFUMHJMZEROT-UHFFFAOYSA-L
CAS データベース:
7681-57-4(CAS DataBase Reference)
EPAの化学物質情報:
Sodium metabisulfite (7681-57-4)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn,Xi
Rフレーズ  22-31-41-36/37/38-52
Sフレーズ  26-39-46-36-16
RIDADR  3260
WGK Germany  1
RTECS 番号 UX8225000
TSCA  Yes
HSCode  2832 10 00
容器等級  III
有毒物質データの 7681-57-4(Hazardous Substances Data)
毒性 LD50 orally in Rabbit: 1540 mg/kg LD50 dermal Rat > 2000 mg/kg
安衛法 57,57-2
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H318 重篤な眼の損傷 眼に対する重篤な損傷性/眼刺激 性 1 危険 P280, P305+P351+P338, P310
注意書き
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

二亜硫酸二ナトリウム 価格 もっと(48)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01AFAA17351 メタ重亜硫酸ナトリウム, 97%
Sodium metabisulfite, 97%
7681-57-4 500g ¥3420 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01AFAA17351 メタ重亜硫酸ナトリウム, 97%
Sodium metabisulfite, 97%
7681-57-4 2500g ¥9730 2018-12-26 購入
関東化学株式会社(KANTO) 37209-00 二亜硫酸ナトリウム >97.0%(T)
Sodium disulfite >97.0%(T)
7681-57-4 500g ¥1800 2018-12-13 購入
関東化学株式会社(KANTO) 37209-01 二亜硫酸ナトリウム >95.0%(T)
Sodium disulfite >95.0%(T)
7681-57-4 500g ¥1700 2018-12-13 購入
Sigma-Aldrich Japan 13459 メタ重亜硫酸ナトリウム
Sodium metabisulfite
puriss., meets analytical specification of Ph. Eur., BP, NF, FCC, E223, dry, 97-100.5%
7681-57-4 500g-r ¥4800 2018-12-25 購入

二亜硫酸二ナトリウム 化学特性,用途語,生産方法

外観

白色の結晶又は結晶性の粉末

定義

本品は、ピロ亜硫酸のナトリウム塩であり、次の化学式で表される。

溶解性

水に易溶。エタノールに不溶。水に溶けやすく、エタノールにほとんど溶けない。

用途

食品中の保存剤、漂白剤、酸化防止剤。還元性を利用して、アスコルビン酸又は染毛剤の抗酸化剤として用いることができる。漂白剤として特殊な化粧料にも用いられる。 サリチル酸製剤などの変色防止剤にも用いられる。化粧品原料(清浄用化粧品、頭髪用化粧品、基礎化粧品、メークアップ化粧品、芳香化粧品、日焼け?日焼け止め化粧品、爪化粧品、入浴用化粧品)

用途

還元剤、漂白剤、写真用薬品。

化粧品の成分用途

還元剤、酸化防止剤

効能

酸化防止剤

使用上の注意

吸湿性あり。空気中で徐々に分解する。

化学的特性

white crystalline powder with a sulfur smell

化学的特性

Sodium metabisulfite is a white crystalline powder. Sulfur dioxide odor. It may be considered the anhydride of 2 molecules of sodium disulfite.

化学的特性

Sodium metabisulfite occurs as colorless, prismatic crystals or as a white to creamy-white crystalline powder that has the odor of sulfur dioxide and an acidic, saline taste. Sodium metabisulfite crystallizes from cold water as a hydrate containing seven water molecules.

使用

Pharmaceutic aid (antioxidant).

使用

sodium metabisulfite is an anti-oxidant and reducing agent.

使用

Sodium Metabisulfite is a preservative and antioxidant that exists as crystals or powder having a sulfur dioxide odor. it is readily solu- ble in water. it is used in dried fruits to preserve flavor, color, and to inhibit undesirable microorganism growth. it prevents “black spots” due to oxidative deterioration in shrimp. it is used in maraschino cherries. it is found in lemon drinks as a preservative. see sulfur dioxide.

定義

ChEBI: An inorganic sodium salt composed of sodium and disulfite ions in a 2:1 ratio.

調製方法

Sodium metabisulfite is prepared by saturating a solution of sodium hydroxide with sulfur dioxide and allowing crystallization to occur; hydrogen is passed through the solution to exclude air. Sodium metabisulfite may also be prepared by saturating a solution of sodium carbonate with sulfur dioxide and allowing crystallization to occur, or by thermally dehydrating sodium bisulfite.

危険性

Toxic by inhalation. Upper respiratory tract irritant. Questionable carcinogen.

応用例(製薬)

Sodium metabisulfite is used as an antioxidant in oral, parenteral, and topical pharmaceutical formulations, at concentrations of 0.01–1.0% w/v, and at a concentration of approximately 27% w/v in intramuscular injection preparations. Primarily, sodium metabisulfite is used in acidic preparations; for alkaline preparations, sodium sulfite is usually preferred. Sodium metabisulfite also has some antimicrobial activity, which is greatest at acid pH, and may be used as a preservative in oral preparations such as syrups.
In the food industry and in wine production, sodium metabisulfite is similarly used as an antioxidant, antimicrobial preservative, and antibrowning agent. However, at concentrations above about 550 ppm it imparts a noticeable flavor to preparations. Sodium metabisulfite usually contains small amounts of sodium sulfite and sodium sulfate.

接触アレルゲン

This agent is frequently used as a preservative in pharmaceutical products, in the bread-making industry as an antioxidant, and it can induce contact dermatitis. It can be used as a reducing agent in photography and caused dermatitis in a photographic technician, probably acting as an aggravating irritative factor. Sodium metabisulfite contains a certain amount of sodium sulfite and sodium sulfate.

安全性プロファイル

An inhalation hazard. Poison by intravenous route. Moderately toxic by parenteral route. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of SOx and Na2O.

安全性

Sodium metabisulfite is widely used as an antioxidant in oral, topical, and parenteral pharmaceutical formulations; it is also widely used in food products.
Although it is extensively used in a variety of preparations, sodium metabisulfite and other sulfites have been associated with a number of severe to fatal adverse reactions. These are usually hypersensitivity-type reactions and include bronchospasm and anaphylaxis. Allergy to sulfite antioxidants is estimated to occur in 5–10% of asthmatics, although adverse reactions may also occur in nonasthmatics with no history of allergy.
Following oral ingestion, sodium metabisulfite is oxidized to sulfate and is excreted in urine. Ingestion may result in gastric irritation, owing to the liberation of sulfurous acid, while ingestion of large amounts of sodium metabisulfite can cause colic, diarrhea, circulatory disturbances, CNS depression, and death.
In Europe, the acceptable daily intake of sodium metabisulfite and other sulfites used in foodstuffs has been set at up to 3.5 mg/kg body-weight, calculated as sulfur dioxide (SO2). The WHO has similarly also set an acceptable daily intake of sodium metabisulfite, and other sulfites, at up to 7.0 mg/kg body-weight, calculated as sulfur dioxide (SO2).
LD50 (rat, IV): 0.12 g/kg

職業ばく露

Sodium metabisulfite is used as an antioxidant in pharmaceutical preparations and as a preservative in foods. People with asthma have a greater chance of having an allergic reaction with this chemical. Individuals allergic to sodium bisulfite (a food preservative found in some wine, fresh shrimp; packaged foods; and restaurant salads and potatoes) may have a severe reaction when exposed to sodium metabisulfite.

貯蔵

On exposure to air and moisture, sodium metabisulfite is slowly oxidized to sodium sulfate with disintegration of the crystals. Addition of strong acids to the solid liberates sulfur dioxide.
In water, sodium metabisulfite is immediately converted to sodium (Na+) and bisulfite (HSO3-) ions. Aqueous sodium metabisulfite solutions also decompose in air, especially on heating. Solutions that are to be sterilized by autoclaving should be filled into containers in which the air has been replaced with an inert gas, such as nitrogen. The addition of dextrose to aqueous sodium metabisulfite solutions results in a decrease in the stability of the metabisulfite.
The bulk material should be stored in a well-closed container, protected from light, in a cool, dry place.

輸送方法

UN1759 Corrosive solids, n.o.s., Hazard class: 8; Labels: 8-Corrosive material, Technical Name required. UN2693 Bisulfites, inorganic, aqueous solutions, n.o.s., Hazard class: 8; Labels: 8-Corrosive material.

不和合性

A strong reducing agent. Keep away from oxidizers. Mixtures with water forms a strong corrosive. Contact with acids releases toxic fumes. Heat causes decomposition. Slowly oxidized to the sulfate on exposure to air and moisture. Attacks metals

不和合性

Sodium metabisulfite reacts with sympathomimetics and other drugs that are ortho- or para-hydroxybenzyl alcohol derivatives to form sulfonic acid derivatives possessing little or no pharmacological activity. The most important drugs subject to this inactivation are epinephrine (adrenaline) and its derivatives. In addition, sodium metabisulfite is incompatible with chloramphenicol owing to a more complex reaction; it also inactivates cisplatin in solution.
It is incompatible with phenylmercuric acetate when autoclaved in eye drop preparations.
Sodium metabisulfite may react with the rubber caps of multidose vials, which should therefore be pretreated with sodium metabisulfite solution.

規制状況(Regulatory Status)

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (epidural;inhalation; IM and IV injections; ophthalmic solutions; oral preparations; rectal, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

二亜硫酸二ナトリウム 上流と下流の製品情報

原材料

準備製品


二亜硫酸二ナトリウム 生産企業

Global( 411)Suppliers
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86-0551-65418684 info@tnjchem.com China 1878 55
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+86-371-55531817
info@dakenchem.com CHINA 21686 58
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0371-55170693
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7681-57-4(二亜硫酸二ナトリウム)キーワード:


  • 7681-57-4
  • SODIUM META-BISULFITE GRAN
  • Sodiummetabisulfite,ACS,97%min
  • Sodium metabisulfite, anhydrous, extra pure, 97%
  • Sodium metabisulfite, for analysis ACS, 97+%
  • SODIUM META BISULFITE REAGENT (ACS)
  • sodium metabisulfite, acs
  • SODIUMMETABISULFITE,ANHYDROUS,GRANULAR,REAGENT,ACS
  • SODIUMMETABISULFITE,FCC(SODIUMBISULFITE)(BULK
  • SODIUMMETABISULFITE,GRANULAR,FCC
  • SODIUMMETABISULFITE,GRANULAR,NF,EP,BP,JP
  • Sodiummetadisulfite
  • NATRIUMPYROSULFIT (NATRIUMDISULFIT)
  • Disodium disulphite
  • Disulfurous acid disodium salt
  • Pyrosulfurous acid disodium salt
  • Sodium metabisulfite
  • Sodium pyrosulfite
  • Sodium metabisulfite, SO2 58.5% min
  • SODIUM METABISULFITE GRANULAR
  • SODIUM METABISULPHITE extrapure AR
  • Sodium disulfite, Sodium pyrosulfite
  • Sodium Metabisulfite, Anhydrous, Granular, Reagent
  • Natrii metabisulfis, Sodium disulfite, Sodium pyrosulfite
  • sodium pyrosulfite for food
  • Sodium metabisulfite, 97%, anhydrous, extra pure
  • Sodium metabisulfite, 97+%, for analysis ACS
  • Sodium metabisulfite, for analysis ACS
  • Sodium metabisulfite,97%,extra pure,anhydrous
  • Sodium disulfite (sodium metabisulfite) for analysis EMSURE ACS,Reag. Ph Eur
  • Sodium metabisulfite anhydrous, free-flowing, Redi-Dri, ReagentPlus, >=99%
  • ピロ亜硫酸ナトリウム
  • メタスルファイトナトリウム
  • 二亜硫酸ジナトリウム
  • 二亜硫酸二ナトリウム
  • メタ重亜硫酸ナトリウム
  • 二亜硫酸ナトリウム
  • メタ重硫酸ナトリウム
  • ピロ亜硫酸Na
  • ピロ亜硫酸ナトリウム(二亜硫酸ナトリウム)
  • 重亜硫酸二ナトリウム
  • 二亜硫酸ナトリウム (固体)
  • ピロ亜硫酸ナトリウム 二亜硫酸ナトリウム
  • メタ重亜硫酸ナトリウム PURISS. P.A.,ACS REAGENT,REAG. PH. EUR.,DRY,98-100.5%
  • メタ重亜硫酸ナトリウム PURISS.,MEETS ANALYTICAL SPECIFICATION OF PH. EUR.,BP,NF,FCC,E223,DRY,97-100.5%
  • メタ重亜硫酸ナトリウム REAGENT GRADE,97%
  • メタ二亜硫酸ナトリウム
  • メタ重亜硫酸ナトリウム, ACS
  • ピロ亜硫酸ナトリウム「製造専用」
  • ピロ亜硫酸ナトリウム( 二亜硫酸ナトリウム)
  • メタ重亜硫酸ナトリウム, 97%
  • メタ重亜硫酸ナトリウム, ACS, 97% min
  • ピロ亜硫酸ナトリウム (JP17)
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