프로카바진 수화염화물 C화학적 특성, 용도, 생산
화학적 성질
Crystalline Solid
용도
Procarbazine hydrochloride USP is used to traet Hodgkin’s disease; non-Hodgkin’s lymphomas; lung cancer.
정의
ChEBI: A hydrochloride obtained by combining procarbazine with one equivalent of hydrochloric acid. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaki
g of DNA strands.
일반 설명
White to pale yellow crystalline powder with a slight odor. Acid to litmus.
공기와 물의 반응
In the presence of moisture or in aqueous solution undergoes oxidation by atmospheric oxygen. Water soluble.
반응 프로필
Procarbazine hydrochloride is very sensitive to light. Stability is highest in aqueous acid and decreases with increasing pH. Degrades rapidly in alcoholic media and more slowly in aqueous media .
화재위험
Flash point data for Procarbazine hydrochloride are not available; however, Procarbazine hydrochloride is probably combustible.
Safety Profile
Confirmed carcinogen
with experimental carcinogenic,
neoplastigenic, tumorigenic, and teratogenic
data. Poison by an unspecified route.
Moderately toxic by ingestion,
subcutaneous, intravenous, and
intraperitoneal routes. Experimental
reproductive effects. Mutation data
reported. When heated to decomposition it
emits very toxic fumes of NOx and HCl.
Used as a chemotherapeutic agent.
잠재적 노출
Procarbazine is available in capsule
form. The primary use of this drug is as an antineoplastic
agent in the treatment of advanced Hodgkin’s disease, and
oat-cell carcinoma of the lung. The hydrochloride com-
pound is used in treatment. The FDA approved use of pro-
carbazine hydrochloride in 1969 and indicated that the drug
should be used as an adjunct to standard therapy. Possible
exposure occurs during manufacture of the drug and direct
exposure during its subsequent administration to patients.
Some of the metabolites of procarbazine hydrochloride are
both carcinostatic and carcinogenic.
운송 방법
UN2811 Toxic solids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required.
비 호환성
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or
explosions. Keep away from alkaline materials, strong
bases, strong acids, oxoacids, epoxides.
폐기물 처리
It is inappropriate and
possibly dangerous to the environment to dispose of
expired or waste drugs and pharmaceuticals by flushing
them down the toilet or discarding them to the trash.
Household quantities of expired or waste pharmaceuticals
may be mixed with wet cat litter or coffee grounds,
double-bagged in plastic, discard in trash. Larger quanti-
ties shall carefully take into consideration applicable
DEA, EPA, and FDA regulations. If possible return the
pharmaceutical to the manufacturer for proper disposal
being careful to properly label and securely package
the material. Alternatively, the waste pharmaceutical
shall be labeled, securely packaged and transported by a
state licensed medical waste contractor to dispose by
burial in a licensed hazardous or toxic waste landfill
or incinerator.
프로카바진 수화염화물 준비 용품 및 원자재
원자재
준비 용품
