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Butylated hydroxyanisole

Butylated hydroxyanisole
Butylated hydroxyanisole structure
Chemical Name:
Butylated hydroxyanisole
BHA;BOA;E320;protex;embanox;tenoxbha;FEMA 2183;sustane1f;antioxyneb;eecno.e320
Molecular Formula:
Formula Weight:
MOL File:

Butylated hydroxyanisole Properties

Melting point:
58-60 °C(lit.)
Boiling point:
0.9976 (rough estimate)
vapor density 
6.2 (vs air)
refractive index 
1.4910 (estimate)
Flash point:
>230 °F
storage temp. 
Practically insoluble in water; soluble in methanol; freely soluble in ≥50% aqueous ethanol, propylene glycol, chloroform, ether, hexane, cottonseed oil, peanut oil, soybean oil, glyceryl monooleate, and lard, and in solutions of alkali hydroxides.
Crystalline Flakes or Crystals
White to pale yellow
Water Solubility 
<0.1 g/100 mL at 18.5 ºC
Stable, combustible. Incompatible with oxidizing agents, ferric salts. Degrades on long exposure to sunlight.
EPA Substance Registry System
Phenol, (1,1-dimethylethyl)-4-methoxy- (25013-16-5)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  22-40-36/37/38-51/53
Safety Statements  36/37-36/37/39-26-61-29
RIDADR  2811
WGK Germany  2
RTECS  SL1945000
Autoignition Temperature 599 °F
HS Code  29093090
Hazardous Substances Data 25013-16-5(Hazardous Substances Data)
Toxicity LD50 in mice, rats (mg/kg): 2000, 2200 orally (Lehman)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P281 Use personal protective equipment as required.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.

Butylated hydroxyanisole price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 78943 Butylated hydroxyanisole analytical standard 25013-16-5 500mg $62.3 2018-11-13 Buy
Sigma-Aldrich 49886 Butylated hydroxyanisole certified reference material, TraceCERT 25013-16-5 50mg $78.8 2018-11-13 Buy
Alfa Aesar B23530 2(3)-tert-Butyl-4-methoxyphenol, 96% 25013-16-5 50g $29.2 2018-11-13 Buy
Alfa Aesar B23530 2(3)-tert-Butyl-4-methoxyphenol, 96% 25013-16-5 250g $75.5 2018-11-13 Buy
Sigma-Aldrich B1253 Butylated hydroxyanisole ≥98.5% 25013-16-5 5g $21.6 2018-11-13 Buy

Butylated hydroxyanisole Chemical Properties,Uses,Production

Chemical Properties

white or light yellow waxy solid with an

Chemical Properties

Log Kow 5. 3. Values above 3.0 are likely to bioaccumulate in aquatic organisms

Chemical Properties

Butylated hydroxyanisole occurs as a white or almost white crystalline powder or a yellowish-white waxy solid with a faint, characteristic aromatic odor.


BHA (butylated hydroxy anisole) is a preservative with anti-oxidant capabilities, not to be confused with beta hydroxy acids (BHAs).


Butylated Hydroxyanisole (BHA) is an antioxidant that imparts stability to fats and oils and should be added before oxidation has started. It is a mixture of 3-tert-butyl-4-hydroxyanisole and 2-tertbutyl-4-hydroxyanisole. In direct addition, the fat or oil is heated to 60–70°C and the BHA is added slowly under vigorous agitation. The maximum concentration is 0.02% based on the weight of the fat or oil. It may protect the fat-soluble vitamins A, D, and E. It is used singly or in combination with other antioxidants. It is used in cereals, edible fat, vegetable oil, confectionary products, and rice.


Butylated Hydroxyanisole is an antioxidant consisting of a mixture of two isomers of tert-butyl-4-hydroxyanisole. Butylated Hydroxyanisole is used in food preservation as it antioxidant properties pre vent food from becoming rancid. Butylated Hydroxyanisoleas is also used in animal feed, petroleum products, and cosmetics.


Antioxidant and preservative, especially in foods, cosmetics, pharmaceuticals; also rubber and petroleum products.


A mixture of 2- and 3-tert-4-methoxyphenol.

Production Methods

Prepared by the reaction of p-methoxyphenol with isobutene.

General Description

White, beige or slightly yellow waxy solid with an aromatic odor and a slightly bitter burning taste.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Butylated hydroxyanisole degrades with prolonged exposure to sunlight. Exhibits antioxidant properties and synergism with acids, BHT, propyl gallate, hydroquinone, methionine, lecithin and thiodipropionic acid. Butylated hydroxyanisole exhibits antioxidant properties as a scavenger of free radicals. Butylated hydroxyanisole is incompatible with oxidizing agents and ferric salts.


Toxic by ingestion. Use in foods restricted; consult FDA regulations.

Fire Hazard

Butylated hydroxyanisole is combustible.

Pharmaceutical Applications

Butylated hydroxyanisole is an antioxidant with some antimicrobial properties. It is used in a wide range of cosmetics, foods, and pharmaceuticals. When used in foods, it is used to delay or prevent oxidative rancidity of fats and oils and to prevent loss of activity of oil-soluble vitamins.
Butylated hydroxyanisole is frequently used in combination with other antioxidants, particularly butylated hydroxytoluene and alkyl gallates, and with sequestrants or synergists such as citric acid.
FDA regulations direct that the total content of antioxidant in vegetable oils and direct food additives shall not exceed 0.02% w/w (200 ppm) of fat or oil content or essential (volatile) oil content of food.
USDA regulations require that the total content of antioxidant shall not exceed 0.01% w/w (100 ppm) of any one antioxidant or 0.02% w/w combined total of any antioxidant combination in animal fats.
Japanese regulations allow up to 1 g/kg in animal fats.

Contact allergens

BHA is an antioxidant widely used in cosmetics and food. Contained in pastry, it can induce sensitization in caterers.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Moderately toxic by ingestion and intraperitoneal routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid and irritating fumes


Butylated hydroxyanisole is absorbed from the gastrointestinal tract and is metabolized and excreted in the urine with less than 1% unchanged within 24 hours of ingestion. Although there have been some isolated reports of adverse skin reactions to butylated hydroxyanisole, it is generally regarded as nonirritant and nonsensitizing at the levels employed as an antioxidant.
Concern over the use of butylated hydroxyanisole has occurred following long-term animal feeding studies. Although previous studies in rats and mice fed butylated hydroxyanisole at several hundred times the US-permitted level in the human diet showed no adverse effects, a study in which rats, hamsters, and mice were fed butylated hydroxyanisole at 1–2% of the diet produced benign and malignant tumors of the forestomach, but in no other sites. However, humans do not have any region of the stomach comparable to the rodent forestomach and studies in animals that also do not have a comparable organ (dogs, monkeys, and guinea pigs) showed no adverse effects. Thus, the weight of evidence does not support any relevance to the human diet where butylated hydroxyanisole is ingested at much lower levels. The WHO acceptable daily intake of butylated hydroxyanisole has been set at 500 μg/kg body-weight.
LD50 (mouse, oral): 1.1–2.0 g/kg
LD50 (rabbit, oral): 2.1 g/kg
LD50 (rat, IP): 0.88 g/kg
LD50 (rat, oral): 2.0 g/kg


Exposure to light causes discoloration and loss of activity. Butylated hydroxyanisole should be stored in a well-closed container, protected from light, in a cool, dry place.


UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1—Poisonous materials, Technical Name Required. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9— Miscellaneous hazardous material, Technical Name Required


Butylated hydroxyanisole is phenolic and undergoes reactions characteristic of phenols. It is incompatible with oxidizing agents and ferric salts. Trace quantities of metals and exposure to light cause discoloration and loss of activity.

Waste Disposal

Suggested: Dispose of contents and container to an approved waste disposal plant. All federal, state, and local environmental regulations must be observed.

Regulatory Status

GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM and IV injections, nasal sprays, oral capsules and tablets, and sublingual, rectal, topical, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

Butylated hydroxyanisole Preparation Products And Raw materials

Raw materials

Preparation Products

Butylated hydroxyanisole Suppliers

Global( 230)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20786 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555 CHINA 1374 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32651 55
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254 CHINA 20229 58
Haihang Industry Co.,Ltd
+86 531 8582 1093 CHINA 4525 58
Zhonglan Industry Co., Ltd.
(86) 531-82956570
(86) 531-82956571 CHINA 749 58
(323) 306-3136
(626) 453-0409 United States 8430 58
career henan chemical co
+86-371-86658258 CHINA 19997 58
Spectrum Chemical Manufacturing Corp. 021-67601398,18616765336,QQ:3003443155
021-57711696 China 9779 60

View Lastest Price from Butylated hydroxyanisole manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-20 Butylated hydroxyanisole
US $1.00 / kg 1kg 98% 100KG career henan chemical co

Butylated hydroxyanisole Spectrum

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