Nisoldipine
- CAS No.
- 63675-72-9
- Chemical Name:
- Nisoldipine
- Synonyms
- Sular;NisoL;SYSCOR;Syseor;Nisocor;NORVASC;Nikameal;ZADIPINA;BAYMYCARD;Nisoldipin
- CBNumber:
- CB5147166
- Molecular Formula:
- C20H24N2O6
- Molecular Weight:
- 388.41
- MDL Number:
- MFCD00478055
- MOL File:
- 63675-72-9.mol
- MSDS File:
- SDS
Melting point | 147-148°C |
---|---|
Boiling point | 503.3±50.0 °C(Predicted) |
Density | 1.205±0.06 g/cm3(Predicted) |
storage temp. | room temp |
solubility | DMSO: >10mg/mL |
pka | 2.67±0.70(Predicted) |
form | powder |
color | yellow |
Merck | 14,6565 |
InChIKey | VKQFCGNPDRICFG-UHFFFAOYSA-N |
CAS DataBase Reference | 63675-72-9(CAS DataBase Reference) |
FDA UNII | 4I8HAB65SZ |
NIST Chemistry Reference | Nisoldipine(63675-72-9) |
ATC code | C08CA07 |
Nisoldipine price More Price(37)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | N0165 | Nisoldipine ≥98% (HPLC) | 63675-72-9 | 10mg | $84.1 | 2024-03-01 | Buy |
Sigma-Aldrich | N0165 | Nisoldipine ≥98% (HPLC) | 63675-72-9 | 50mg | $351 | 2024-03-01 | Buy |
TCI Chemical | N0900 | Nisoldipine >98.0%(HPLC)(N) | 63675-72-9 | 1g | $91 | 2024-03-01 | Buy |
TCI Chemical | N0900 | Nisoldipine >98.0%(HPLC)(N) | 63675-72-9 | 5g | $227 | 2024-03-01 | Buy |
Alfa Aesar | H37972 | Nisoldipine 98% | 63675-72-9 | 1g | $119 | 2023-06-20 | Buy |
Nisoldipine Chemical Properties,Uses,Production
Description
Nisoldipine D4 is another long-acting dihydropyridine calcium channel blocker effective in the treatment of hypertension and angina pectoris. It is reported to have little or no cardiodepressive activity and to be more effective than nifedipine in reducing blood pressure in hypertensives. Nisoldipine has also been shown to be effective in the management of congestive heart failure. Reduction in dosage is necessary in patients with hepatic, but not renal impairment.
Chemical Properties
Nisoldipine D4 is Light Tan Crystals
Originator
Bayer AG (Germany)
Uses
urease inhibitor
Uses
Labeled Nisoldipine, intended for use as an internal standard for the quantification of Nisoldipine by GC- or LC-mass spectrometry.
Uses
Dihydropyridine calcium channel blocker. Antihypertensive and antianginal
Definition
ChEBI: A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a methoxycarbonyl group at position 3, an o-nitrophenyl group at position 4, and an isobutoxycarbonyl group at position 5. The racemate, calcium channel blocker, is used in the treatment of hypertension and angina pectoris.
Manufacturing Process
Boiling a solution of 12.7 g of 2'-nitrobenzylideneacetoacetic acid methyl ester and 7.1 g of β-amino-crotonic acid isopropyl ester in 50 ml of methanol for 10 hours yielded 2,6-dimethyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-3,5- dicarboxylic acid 3-methyl ester-5-isopropyl ester of melting point 174°C (from ethanol). Yield 48% of theory.
brand name
Sular (Sciele);Baymycard.
Therapeutic Function
Coronary vasodilator
General Description
In vitro studies show that the effects ofnisoldipine, 1,4-dihydro-2, 6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinecarboxylic acid methyl 2-methylpropyl ester(Sular), on contractile processes are selective, with greaterpotency on vascular smooth muscle than on cardiac muscle.
Nisoldipine is highly metabolized, with five majormetabolites identified. As with most of the dihydropyridines,the cytochrome P450 (CYP) 3A4 isozyme is mainlyresponsible for the metabolism of nisoldipine. The majorbiotransformation pathway appears to involve the hydroxylationof the isobutyl ester side chain. This particular metabolitehas approximately 10% of the activity of the parentcompound.
Biochem/physiol Actions
L-type (CaV1.2) calcium channel blocker; dihydropyridine-type calcium channel blocker with selectivity for smooth muscle (CaV1.2b) over cardiac muscle (CaV1.2a). Arterial vasodilator and antihypertensive agent.
Nisoldipine Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12446 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Jinan Jianfeng Chemical Co., Ltd | +8615562555968 | info@pharmachemm.com | China | 247 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hebei Jimi Trading Co., Ltd. | +86 319 5273535 | bestoneforyou@sina.com | CHINA | 288 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8820 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
View Lastest Price from Nisoldipine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-18 | Nisoldipine
63675-72-9
|
US $0.00 / KG | 1KG | 98.0% | 500kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
2023-09-05 | Nisoldipine
63675-72-9
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | ||
2023-08-16 | Nisoldipine
63675-72-9
|
US $500.00 / KG | 1KG | >99% | 50000kg/Month | Weijer International Trade (Hebei) Co., Ltd |
- Nisoldipine
63675-72-9
- US $0.00 / KG
- 98.0%
- WUHAN FORTUNA CHEMICAL CO., LTD
- Nisoldipine
63675-72-9
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
- Nisoldipine
63675-72-9
- US $500.00 / KG
- >99%
- Weijer International Trade (Hebei) Co., Ltd