3-히드록시-3-메틸글루타산
|
|
3-히드록시-3-메틸글루타산 속성
- 녹는점
- 105-108 °C (lit.)
- 끓는 점
- 120 °C / 13mmHg
- 밀도
- 1.2132 (rough estimate)
- 굴절률
- 1.4230 (estimate)
- 저장 조건
- -20°C
- 용해도
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): 10 mg/ml
- 물리적 상태
- powder to crystal
- 산도 계수 (pKa)
- 3.95±0.10(Predicted)
- 색상
- 흰색에서 밝은 노란색
- Merck
- 14,5808
- BRN
- 1769194
- CAS 데이터베이스
- 503-49-1(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38 | ||
| 안전지침서 | 22-24/25-36-26 | ||
| WGK 독일 | 2 | ||
| RTECS 번호 | MA3753000 | ||
| F 고인화성물질 | 10 | ||
| HS 번호 | 29181990 | ||
| 독성 | LD50 in mice (g/kg): 7.33 orally; 3.23 i.p. (Savoie, Lupien) |
3-히드록시-3-메틸글루타산 C화학적 특성, 용도, 생산
개요
Meglutol (β-hydroxy-β-methylglutaric acid; HMG) is a hypolipidemic agent that acts via the inhibition of cholesterol synthesis a t the stage of HMG-CoAreductase, blocking the conversion of HMG-CoA to mevalonate. This conversion is the rate-limiting step in cholesterol biosynthesis and is the point of physiological feedback control; as such, it appears to be the ideal locus of action for a hypolipidemic agent. Investigational compounds that act by this mechanism include the natural products compactin and mevinolin.화학적 성질
White Solid용도
antihyperlipoproteinemia정의
ChEBI: A dicarboxylic acid that is glutaric acid in which one of the two hydrogens at position 3 is substituted by a hydroxy group, while the other is substituted by a methyl group. It has been found to accumulate in urine of patients suffering from HMG-CoA lyase (3-hydroxy-3-methylglutaryl-CoA lyase, EC 4.1.3.4) deficiency. It occurs as a plant metabolite in Crotalaria dura.Purification Methods
Recrystallise the acid from diethyl ether/hexane and dry it under avacuum at 60o for 1hour. [Beilstein 3 IV 1166.]3-히드록시-3-메틸글루타산 준비 용품 및 원자재
원자재
준비 용품
3-히드록시-3-메틸글루타산 공급 업체
글로벌( 113)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 |
sales@biopurify.com | China | 3424 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49390 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 |
eric@witopchemical.com | China | 23556 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 29220 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 |
alfa4@alfachem.cn | China | 12755 | 58 |
| VladaChem GmbH | +49-7246-3082843 |
info@vladachem.de | Germany | 1860 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 |
sales@dogechemical.com | China | 4128 | 58 |