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Rocuronium bromide

Rocuronium bromide 구조식 이미지
카스 번호:
119302-91-9
상품명:
Rocuronium bromide
동의어(영문):
Eslax;Esmeron;Zemuron;Org-9426;Esmeron:Zemuron;ROCURONIUN BROMIDE;ROCURONIUM BROMIDE;RocuroniuM BroMideAPI;Rocuronium hydrobromide;RocuroniuM BroMide IsoMers
CBNumber:
CB2222507
분자식:
C32H53BrN2O4
포뮬러 무게:
609.68
MOL 파일:
119302-91-9.mol

Rocuronium bromide 속성

녹는점
162-1640C
알파
D20 +18.7° (c = 1.03 in CHCl3)
저장 조건
Room temp
용해도
H2O: soluble100mg/mL, clear, light yellow
물리적 상태
neat
Merck
14,8246
InChIKey
OYTJKRAYGYRUJK-FMCCZJBLSA-M
CAS 데이터베이스
119302-91-9(CAS DataBase Reference)

안전

WGK 독일 3

Rocuronium bromide C화학적 특성, 용도, 생산

개요

Rocuronium bromide is a short-acting nondepolarizing steroidal neuromuscular blocker introduced in the U.S.A as Zemuron and in the United Kingdom as Esmeron. k is indicated for use as an adjunct to general anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Rocuroniurn bromide has a significantly more rapid onset than other intermediate acting neuromuscular blockers, comparable to succinylcholine but with a very stable cardiovascular profile and has an improved side effect profile. It has been reported that good to excellent intubation conditions were achieved only one minute after a bolus dose of 600μg/kg of rocuronium bromide. It has a short duration of action, therefore, is useful for rapid sequence intubation without unacceptable delays in the spontaneous recovery of neuromuscular function.

화학적 성질

Off-white Solid

Originator

Organon (Netherlands)

용도

Aminosteroid, competitive neuromuscular blocker

용도

A non-depolarizing neuromuscular blocker used in anesthesia to help insert breathing tubes.

정의

ChEBI: The organic bromide salt of a 5alpha androstane compound having 3alpha-hydroxy-, 17beta-acetoxy-, 2beta-morpholino- and 16beta-N-allyllyrrolidinium subs ituents.

상표명

Zemuron (Organon).

Biological Functions

Rocuronium bromide (Zemuron) is a recently approved amino steroid neuromuscular blocking agent. It has a rapid onset of action (1 minute), but its duration of action is intermediate (55 minutes), about that of vecuronium. On rare occasions, it may release histamine and cause cardiac irregularities. Rapacuronium bromide (Raplon) is the most recent neuromuscular blocking agent approved by the United States Food and Drug Administration (FDA). It is an analogue of vecuronium and is thus categorized as an amino steroid. It has a rapid onset of action (1.5 minutes) and a short to intermediate duration of action (20 minutes).This makes it a suitable alternative to mivacurium or succinylcholine for short procedures. It is eliminated mainly by the liver.Adverse effects are dose dependent; they include tachycardia, hypotension, and bronchospasm. These effects may be related to the ability of the drug to release a small amount of histamine.

Rocuronium bromide 준비 용품 및 원자재

원자재

준비 용품


Rocuronium bromide 공급 업체

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