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all-trans-Retinol

all-trans-Retinol
all-trans-Retinol structure
CAS No.
68-26-8
Chemical Name:
all-trans-Retinol
Synonyms
Acon;Atav;-1-ol;Aoral;A-Sol;Atars;Avita;Vogan;Vafol;Vio-A
CBNumber:
CB8194893
Molecular Formula:
C20H30O
Formula Weight:
286.45
MOL File:
68-26-8.mol

all-trans-Retinol Properties

Melting point:
61-63 °C(lit.)
Boiling point:
368.81°C (rough estimate)
Density 
0.9933 (rough estimate)
refractive index 
1.641
Flash point:
-26 °C
storage temp. 
2-8°C
pka
14.09±0.10(Predicted)
form 
crystalline
color 
yellow to orange
Water Solubility 
Practically insoluble inwaterorglycerol; soluble in absolute alcohol,methanol,℃hloroform, ether, fats and oils.
Sensitive 
Moisture & Light Sensitive
Merck 
13,10073
BRN 
403040
Stability:
Stable, but light and air sensitive. Incompatible with strong acids, strong oxidizing agents.
SCOGS (Select Committee on GRAS Substances)
Vitamin A
CAS DataBase Reference
68-26-8(CAS DataBase Reference)
FDA 21 CFR
184.1930; 582.5930; 101.9; 104.20; 107.10; 107.100; 310.545
Substances Added to Food (formerly EAFUS)
VITAMIN A
EWG's Food Scores
6-9
FDA UNII
81G40H8B0T
NCI Dictionary of Cancer Terms
Avita; retinol; vitamin A
EPA Substance Registry System
Retinol (68-26-8)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08,GHS02,GHS07
Signal word  Danger
Hazard statements  H317-H319-H360-H413-H225-H302
Precautionary statements  P201-P280-P305+P351+P338-P308+P313-P210-P337+P313-P403+P235-P261-P405-P501a
Hazard Codes  Xn,N,F,T
Risk Statements  22-38-67-65-62-51/53-48/20-11-43-61-63-36/38
Safety Statements  36/37-61-62-45-53-16-33-29-9-36/37/39-26
RIDADR  UN 1208 3/PG 2
WGK Germany  3
RTECS  VH6750000
8-10-16-23
TSCA  Yes
HS Code  29362100
Toxicity LD50 (10 day) in mice (mg/kg): 1510 i.p.; 2570 orally (Kamm)

all-trans-Retinol price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 17772 Retinol AldrichCPR 68-26-8 250mg $139 2019-12-02 Buy
Sigma-Aldrich 17772 Retinol ≥95.0% (HPLC), ~2700 U/mg 68-26-8 1g $438 2019-12-02 Buy
Alfa Aesar J62079 Retinol, 95%, synthetic 68-26-8 1g $224 2020-06-24 Buy
Alfa Aesar J62079 Retinol, 95% synthetic 68-26-8 100mg $52.7 2020-06-24 Buy
Cayman Chemical 20241 Vitamin A ≥98% 68-26-8 50mg $25 2020-06-24 Buy

all-trans-Retinol Chemical Properties,Uses,Production

Chemical Properties

Yellow-Orange Powder

Uses

mucolytic

Uses

vitamin A (Retinol) is the fat-soluble vitamin a which is required for new cell growth and prevention of night blindness. There is no appreciable loss by heating or freezing, and it is stable in the absence of air. Sources include liver, fortified margarine, egg, and milk. Vitamin A palmitate can be found in frozen egg substitute.

Uses

Occurs preformed only in animals; metabolized from carotenoids, such β-carotene, in the intestinal mucosa. Dietary sources include liver, milk, butter, cheese, eggs and fish liver oils or as carotenoi s from fruits and vegetables. Stored primarily in the liver in esterified form; transported in the blood by retinol binding protein (RBP). Nutritional factor.

Uses

Atracurium Besilate intermediate

Uses

retinol is a retinoid considered to be a skin revitalizer. It is reported to enhance skin radiance and treat conditions associated with chronological aging, such as wrinkles and fine lines, as well as dermatological disorders, including acne, follicular and lesion papules, actinic keratosis, oily skin, and rosacea. According to clinical dermatologists, retinol is one of the few substances with a demonstrated ability to reduce and prevent fine lines and wrinkles. It is able to alter the behavior of aged cells so they act in a more youthful manner. It is considered necessary for normal epidermal cell growth and differentiation and stimulates the production of new blood vessels in the skin, improving skin tone. In addition, retinol has anti-oxidant capacities and protects dermal fibers by counteracting the increased activity of enzymes that degrade collagen and elastin when the skin is exposed to uV rays. Retinol can be drying to the skin when used for a prolonged period of time or in concentrations that are too high. A weaker retinoid than retinoic acid, retinol converts to retinoic acid once on the skin. When compared to retinoic acid, retinol has an increased penetration potential and is less irritating, making it an effective ingredient for anti-aging products. The anti-aging benefits of topically treating skin with retinol are based on its penetration ability, which allows it to reach the sites in the skin requiring treatment. When used on sensitive skin for a prolonged period of time or in concentrations that are too high, retinol can cause dermatitis.

Uses

Vitamin A1 (retinal) is produced from (3-carotene, which can be obtained by fermentation of corn, soybean meal, kerosene, thiamin, and oc-ionone. The dry-mass after fermentation contains 120 to 150 g product/kg.

Indications

Vitamin A, or retinol, is essential for the proper maintenance of the functional and structural integrity of epithelial cells, and it plays a major role in epithelial differentiation. Bone development and growth in children have also been linked to adequate vitamin A intake. Vitamin A, when reduced to the aldehyde 11-cis-retinal, combines with opsin to produce the visual pigment rhodopsin. This pigment is present in the rods of the retina and is partly responsible for the process of dark adaptation.

Definition

ChEBI: A retinol in which all four exocyclic double bonds have E- (trans-) geometry.

brand name

Avibon.

World Health Organization (WHO)

Vitamin A, a fat-soluble vitamin, is used in the treatment and prevention of vitamin A deficiency resulting from inadequate dietary intake. It has been demonstrated to be teratogenic at high doses (more than 25,000 IU per day). Daily dosages of less than 10000 IU seem to be free of this risk. Retinol (vitamin A) is listed in the WHO Model List of Essential Drugs.

Clinical Use

Principal dietary sources of vitamin A are milk fat (cheese and butter) and eggs. Since it is stored in the liver, inclusion of liver in the diet also provides vitamin A. A plant pigment, carotene, is a precursor for vitamin A and is present in highly pigmented vegetables, such as carrots, rutabaga, and red cabbage.
An early sign of hypovitaminosis A is night blindness. This condition is related to the role of vitamin A as the prosthetic group of the visual pigment rhodopsin. The night blindness may progress to xerophthalmia (dryness and ulceration of the cornea) and blindness. Other symptoms of vitamin A deficiency include cessation of growth and skin changes due to hyperkeratosis.
Since vitamin A is a fat-soluble vitamin, any disease that results in fat malabsorption and impaired liver storage brings with it the risk of vitamin A deficiency; these conditions include biliary tract disease, pancreatic disease, sprue, and hepatic cirrhosis. One group at great risk are children from low-income families, who are likely to lack fresh vegetables (carotene) and dairy products (vitamin A) in the diet.

Side effects

Acute hypervitaminosis A results in drowsiness, headache, vomiting, papilledema, and a bulging fontanel in infants. The symptoms of chronic toxicity include scaly skin, hair loss, brittle nails, and hepatosplenomegaly. Anorexia, irritability, and swelling of the bones have been seen in children. Retardation of growth also may occur. Liver toxicity has been associated with excessive vitamin A intake. Vitamin A is teratogenic in large amounts, and supplements should not be given during a normal pregnancy. The IOM has reported the UL of vitamin A to be 3,000 μg/day.

Safety Profile

Moderately toxic by ingestion. Human teratogenic effects by ingestion: developmental abnormalities of the craniofacial area and urogenital system. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Purify retinol by chromatography on columns of water-deactivated alumina and elute with 3-5% acetone in hexane. Separate the isomers by TLC plates on silica gel G, developed with pet ether (low boiling)/methyl heptanone (11:2). Store it in the dark, under N2, at 0o, or in Et2O, Me2CO or EtOAc. [See Gunghaly et al. Arch Biochem Biophys 38 75 1952, Beilstein 6 IV 4133.]

all-trans-Retinol Preparation Products And Raw materials

Raw materials

Preparation Products


all-trans-Retinol Suppliers

Global( 263)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651
whatsapp: +8619930501651 breeduan@crovellbio.com CHINA 2581 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 19929 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21838 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30043 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
Chemwill Asia Co.,Ltd.
86-21-51086038
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Related articles


View Lastest Price from all-trans-Retinol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-07-13 Retinol; Vitamin A
68-26-8
US $50.00 / Kg/Drum 25KG 99% 1000tons/month Hebei Yanxi Chemical Co., Ltd.
2020-06-26 Vitamin A
68-26-8
US $100.00 / KG 1KG 99% 10T Nanjing Sky Hope Tongyuan Biological Engineering Co., Ltd.
2020-04-15 VITAMIN A Joyce
68-26-8
US $20.00 / KG 1KG 99% 20tons Hebei Guanlang Biotechnology Co., Ltd.

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